Protein: CWC25
Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25)

Gene: CWC25
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q9NXE8

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005684 - U2-type spliceosomal complex
GO:0016607 - nuclear speck

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

623572

RO52
E3 ubiquitin-protein ligase TRIM21

2

0

High-throughput

0.580

High

1128126

DHX8
ATP-dependent RNA helicase DHX8

2

3

High-throughput

0.571

High

1361022

P66B
Transcriptional repressor p66-beta

2

0

High-throughput

0.559

High

717357

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

1028417

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.537

High

659307

SP100
Nuclear autoantigen Sp-100

1

4

High-throughput

0.536

High

991441

SUMO1
Small ubiquitin-related modifier 1

1

1

High-throughput

0.536

High

1413565

H2AJ
Histone H2A.J

1

1

High-throughput

0.536

High

1154602

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

159883

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.513

High

948595

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1016385

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1023630

CYC
Cytochrome c

1

0

High-throughput

0.513

High

1272574

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

1368805

EZH1
Histone-lysine N-methyltransferase EZH1

1

0

High-throughput

0.513

High

1451987

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1121154

UBE4A
Ubiquitin conjugation factor E4 A

1

0

High-throughput

0.493

High

1057001

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.481

High

186071

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

141142

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

287169

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

2

High-throughput

0.479

High

317010

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

401589

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

406724

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

872807

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

1102667

MTA1
Metastasis-associated protein MTA1

1

1

High-throughput

0.479

High

1110126

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1140940

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1311875

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.479

High

1313474

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1368152

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1404455

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1414595

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1451983

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1313084

Q8IXW7
FMR1 protein

1

3

High-throughput

0.470

High

971184

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

979303

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1281623

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1410852

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1448819

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1451985

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1451988

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1309254

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.437

High

1447269

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.437

High

995307

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.426

High

1119331

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

300515

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.316

High

169215

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

354040

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

488086

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

515907

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

694409

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

1092829

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1093777

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1360762

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

1384729

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1449799

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1451984

CYH4
Cytohesin-4

1

0

High-throughput

0.279

Low

1451986

ANR50
Ankyrin repeat domain-containing protein 50

1

0

High-throughput

0.279

Low

1451990

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.251

Low

281436

GGYF1
GRB10-interacting GYF protein 1

1

0

High-throughput

0.249

Low

640308

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

1276170

NUP54
Nucleoporin p54

1

0

High-throughput

0.249

Low

1451982

CING
Cingulin

1

0

High-throughput

0.249

Low

1451989

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025