Protein: NUP54
Nucleoporin p54 (54 kDa nucleoporin)

Gene: NUP54
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q7Z3B4

Gene Ontology (top 5):
GO:0005635 - nuclear envelope
GO:0005643 - nuclear pore
GO:0006607 - NLS-bearing protein import into nucleus
GO:0006913 - nucleocytoplasmic transport
GO:0006999 - nuclear pore organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1276153

NUP58
Nucleoporin p58/p45

11

19

High-throughput

0.980

High

789152

NUP62
Nuclear pore glycoprotein p62

11

20

Small-scale

0.979

High

1276157

N62CL
Nucleoporin-62 C-terminal-like protein

3

17

High-throughput

0.858

High

1276138

NU205
Nuclear pore complex protein Nup205

2

12

High-throughput

0.754

High

965559

NTF2
Nuclear transport factor 2

3

9

Small-scale

0.658

High

1276129

HOME1
Homer protein homolog 1

4

2

High-throughput

0.638

High

169615

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

4

2

High-throughput

0.637

High

1276156

NDEL1
Nuclear distribution protein nudE-like 1

4

5

High-throughput

0.629

High

981560

RAN
GTP-binding nuclear protein Ran

2

3

High-throughput

0.621

High

172999

XPO1
Exportin-1

2

20

Small-scale

0.611

High

989028

AP2B1
AP-2 complex subunit beta

3

3

High-throughput

0.609

High

1276148

WDFY2
WD repeat and FYVE domain-containing protein 2

3

7

High-throughput

0.609

High

1276151

TCHP
Trichoplein keratin filament-binding protein

2

3

High-throughput

0.606

High

1276126

NUP54
Nucleoporin p54

1

17

Small-scale

0.590

High

1276132

NUP35
Nucleoporin NUP35

2

4

High-throughput

0.584

High

253965

LPXN
Leupaxin

2

3

High-throughput

0.574

High

1091016

BFSP1
Filensin

2

2

High-throughput

0.574

High

1245307

WDR59
GATOR2 complex protein WDR59

2

5

High-throughput

0.574

High

1276152

CP250
Centrosome-associated protein CEP250

2

5

High-throughput

0.574

High

1276166

HOME3
Homer protein homolog 3

2

2

High-throughput

0.574

High

1276171

NDE1
Nuclear distribution protein nudE homolog 1

2

3

High-throughput

0.574

High

1276175

CRNN
Cornulin

2

1

High-throughput

0.574

High

618062

K1C15
Keratin, type I cytoskeletal 15

2

2

High-throughput

0.573

High

1276140

RN166
E3 ubiquitin-protein ligase RNF166

2

5

High-throughput

0.558

High

63220

VP37C
Vacuolar protein sorting-associated protein 37C

2

4

High-throughput

0.553

High

353415

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.553

High

447796

TPM3
Tropomyosin alpha-3 chain

2

1

High-throughput

0.553

High

1083264

AP1B1
AP-1 complex subunit beta-1

2

3

High-throughput

0.553

High

1127654

KT33B
Keratin, type I cuticular Ha3-II

2

1

High-throughput

0.553

High

1276128

K1C27
Keratin, type I cytoskeletal 27

2

1

High-throughput

0.553

High

1276131

EXOC8
Exocyst complex component 8

2

1

High-throughput

0.553

High

1276134

IKBD
NF-kappa-B inhibitor delta

2

1

High-throughput

0.553

High

1276135

CCHCR
Coiled-coil alpha-helical rod protein 1

2

4

High-throughput

0.553

High

1276179

CDC23
Cell division cycle protein 23 homolog

2

3

High-throughput

0.553

High

1276181

TACC3
Transforming acidic coiled-coil-containing protein 3

2

4

High-throughput

0.553

High

849364

RANG
Ran-specific GTPase-activating protein

1

16

High-throughput

0.536

High

945262

NU107
Nuclear pore complex protein Nup107

1

10

High-throughput

0.536

High

1276137

CHMP7
Charged multivesicular body protein 7

1

1

High-throughput

0.536

High

242120

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.533

High

911284

IMA5
Importin subunit alpha-5

1

11

Small-scale

0.501

High

1134253

IMB1
Importin subunit beta-1

1

20

Small-scale

0.501

High

668643

APC
Adenomatous polyposis coli protein

1

5

High-throughput

0.494

High

424517

PAI2
Plasminogen activator inhibitor 2

1

1

High-throughput

0.489

High

721025

CLIP1
CAP-Gly domain-containing linker protein 1

1

6

High-throughput

0.489

High

1100861

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

High-throughput

0.489

High

1134623

NUMA1
Nuclear mitotic apparatus protein 1

1

6

High-throughput

0.489

High

1152127

MARE1
Microtubule-associated protein RP/EB family member 1

1

3

High-throughput

0.489

High

1276133

NEDD1
Protein NEDD1

1

4

High-throughput

0.489

High

1276141

SPSB4
SPRY domain-containing SOCS box protein 4

1

8

High-throughput

0.489

High

1276165

GDF3
Growth/differentiation factor 3

1

2

High-throughput

0.489

High

291403

NU155
Nuclear pore complex protein Nup155

1

15

High-throughput

0.479

High

775562

NU214
Nuclear pore complex protein Nup214

1

18

Small-scale

0.479

High

915986

NUP98
Nuclear pore complex protein Nup98-Nup96

1

19

High-throughput

0.479

High

1199321

GLE1
mRNA export factor GLE1

1

10

High-throughput

0.479

High

1276176

NXF1
Nuclear RNA export factor 1

1

11

High-throughput

0.479

High

1276177

IPO11
Importin-11

1

20

High-throughput

0.479

High

1276180

DD19B
ATP-dependent RNA helicase DDX19B

1

4

High-throughput

0.479

High

185811

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.457

High

1276136

NU133
Nuclear pore complex protein Nup133

1

9

Small-scale

0.457

High

1276144

P121A
Nuclear envelope pore membrane protein POM 121

1

11

Small-scale

0.457

High

404163

GCR
Glucocorticoid receptor

1

5

Small-scale

0.439

High

1276155

TRI54
Tripartite motif-containing protein 54

1

7

High-throughput

0.439

High

157549

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.437

High

213472

CTIF
CBP80/20-dependent translation initiation factor

1

1

High-throughput

0.437

High

247978

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

272285

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

372413

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

412166

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

832996

ETV6
Transcription factor ETV6

1

2

High-throughput

0.437

High

934792

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.437

High

1047921

TLE2
Transducin-like enhancer protein 2

1

7

High-throughput

0.437

High

1048018

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.437

High

1109842

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.437

High

1135723

HAPR1
HUWE1-associated protein modifying stress responses 1

1

3

Small-scale

0.437

High

1161512

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.437

High

1220999

FBW10
F-box/WD repeat-containing protein 10

1

4

High-throughput

0.437

High

1226956

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

1250577

DPPA3
Developmental pluripotency-associated protein 3

1

3

High-throughput

0.437

High

1254403

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1276127

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1276147

SCLT1
Sodium channel and clathrin linker 1

1

8

High-throughput

0.437

High

1276149

LMTK3
Serine/threonine-protein kinase LMTK3

1

5

High-throughput

0.437

High

1276159

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1276164

ANLN
Anillin

1

1

High-throughput

0.437

High

142360

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.407

High

1276167

EXOC1
Exocyst complex component 1

5

0

High-throughput

0.374

High

1276130

IFT20
Intraflagellar transport protein 20 homolog

3

0

High-throughput

0.352

High

1276143

CPNE2
Copine-2

3

0

High-throughput

0.345

High

1025564

CDK16
Cyclin-dependent kinase 16

2

0

High-throughput

0.328

High

1276161

COG4
Conserved oligomeric Golgi complex subunit 4

2

0

High-throughput

0.328

High

131459

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.316

High

217129

MS18B
Protein Mis18-beta

2

0

High-throughput

0.316

High

298194

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.316

High

329943

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

2

0

High-throughput

0.316

High

1207225

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.316

High

1207365

EFHC1
EF-hand domain-containing protein 1

2

0

High-throughput

0.316

High

1276139

TEKT1
Tektin-1

2

0

High-throughput

0.316

High

1276145

PKNX2
Homeobox protein PKNOX2

2

0

High-throughput

0.316

High

1276150

HAUS8
HAUS augmin-like complex subunit 8

2

0

High-throughput

0.316

High

1276154

TEX12
Testis-expressed protein 12

2

0

High-throughput

0.316

High

1276158

CENPH
Centromere protein H

2

0

High-throughput

0.316

High

1276160

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.316

High

1276162

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1276168

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.316

High

1276169

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.316

High

1276172

EURL
Protein EURL homolog

2

0

High-throughput

0.316

High

1276174

SPG21
Maspardin

2

0

High-throughput

0.316

High

1276142

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.299

High

1120859

DGCR6
Protein DGCR6

1

0

High-throughput

0.282

High

1154533

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

774083

ADDA
Alpha-adducin

1

0

High-throughput

0.279

Low

1165418

TIGD6
Tigger transposable element-derived protein 6

1

0

High-throughput

0.279

Low

1276163

PRDM7
Histone-lysine N-methyltransferase PRDM7

1

0

High-throughput

0.269

Low

167301

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.268

Low

441552

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

562169

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

719966

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

937046

CASP6
Caspase-6

1

0

High-throughput

0.268

Low

1276178

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.268

Low

176504

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

851598

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.249

Low

1276170

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.249

Low

1276173

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1104002

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1276146

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025