Protein: INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)

Gene: INP5E, INPP5E
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9NRR6

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001726 - ruffle
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 - inositol-polyphosphate 5-phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

966923

1433G
14-3-3 protein gamma

4

17

High-throughput

0.697

High

1049824

1433F
14-3-3 protein eta

4

17

High-throughput

0.694

High

972045

1433E
14-3-3 protein epsilon

3

3

High-throughput

0.675

High

730280

1433B
14-3-3 protein beta/alpha

3

16

High-throughput

0.662

High

231407

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

3

0

Small-scale

0.634

High

990781

1433Z
14-3-3 protein zeta/delta

1

17

High-throughput

0.536

High

1369266

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

1

High-throughput

0.536

High

938821

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

0

High-throughput

0.493

High

176882

DCLK1
Serine/threonine-protein kinase DCLK1

1

1

High-throughput

0.479

High

230575

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.479

High

269618

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.479

High

281432

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

339110

NADK
NAD kinase

1

1

High-throughput

0.479

High

637960

NF1
Neurofibromin

1

5

High-throughput

0.479

High

941068

HDAC4
Histone deacetylase 4

1

5

High-throughput

0.479

High

964754

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.479

High

1065770

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

1

High-throughput

0.479

High

1090192

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

4

High-throughput

0.479

High

1092498

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

6

High-throughput

0.479

High

1152052

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

4

High-throughput

0.479

High

1211004

CE170
Centrosomal protein of 170 kDa

1

3

High-throughput

0.479

High

1216096

SPD2A
SH3 and PX domain-containing protein 2A

1

20

High-throughput

0.479

High

1219625

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

1234977

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.479

High

1251453

GGYF2
GRB10-interacting GYF protein 2

1

8

High-throughput

0.479

High

1277712

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.479

High

1286549

PHLB2
Pleckstrin homology-like domain family B member 2

1

5

High-throughput

0.479

High

1293246

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

1309253

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

1352613

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1356772

HDAC7
Histone deacetylase 7

1

5

High-throughput

0.479

High

1401119

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

4

High-throughput

0.479

High

1448821

CING
Cingulin

1

3

High-throughput

0.479

High

1448822

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1448823

XPO7
Exportin-7

1

6

High-throughput

0.479

High

1448824

NGAP
Ras GTPase-activating protein nGAP

1

5

High-throughput

0.479

High

1448826

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1448828

STA13
StAR-related lipid transfer protein 13

1

3

High-throughput

0.479

High

1448829

KCTD3
BTB/POZ domain-containing protein KCTD3

1

1

High-throughput

0.479

High

208741

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

252176

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

719376

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

1134064

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1151393

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1322656

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1402219

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1409791

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1410851

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1412883

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1419837

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

1448819

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.458

High

1448820

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

1448825

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1448827

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

245278

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

1

High-throughput

0.437

High

1216028

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

6

High-throughput

0.437

High

1272887

RFIP2
Rab11 family-interacting protein 2

1

2

High-throughput

0.437

High

1338117

NAV1
Neuron navigator 1

1

2

High-throughput

0.437

High

1352637

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.437

High

1438849

TANC2
Protein TANC2

1

1

High-throughput

0.437

High

1447268

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.437

High

1429325

MFR1L
Mitochondrial fission regulator 1-like

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025