Protein: IF5
Eukaryotic translation initiation factor 5 (eIF-5)

Gene: IF5, TIF5
Organism: Saccharomyces cerevisiae S288C
Interactions: 91
UniProt ID: P38431

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003743 - translation initiation factor activity
GO:0005092 - GDP-dissociation inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

748165

SUI1
Eukaryotic translation initiation factor eIF-1

11

3

Small-scale

0.977

High

737713

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

10

11

Small-scale

0.975

High

799746

IF2P
Eukaryotic translation initiation factor 5B

3

4

High-throughput

0.855

High

738585

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

12

Small-scale

0.768

High

738375

EIF3C
Eukaryotic translation initiation factor 3 subunit C

17

3

Small-scale

0.766

High

438424

EIF3B
Eukaryotic translation initiation factor 3 subunit B

15

5

Small-scale

0.762

High

478615

IF2B
Eukaryotic translation initiation factor 2 subunit beta

12

9

Small-scale

0.760

High

799750

EIF3I
Eukaryotic translation initiation factor 3 subunit I

12

7

Small-scale

0.759

High

632886

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

10

7

Small-scale

0.755

High

796563

EIF3A
Eukaryotic translation initiation factor 3 subunit A

7

5

Small-scale

0.746

High

799768

EIF3G
Eukaryotic translation initiation factor 3 subunit G

4

4

Small-scale

0.691

High

799771

EIF3J
Eukaryotic translation initiation factor 3 subunit J

5

0

Small-scale

0.684

High

799744

IF1A
Eukaryotic translation initiation factor 1A

1

1

Small-scale

0.647

High

726983

HS104
Heat shock protein 104

3

3

Small-scale

0.640

High

799747

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

3

Small-scale

0.629

High

799766

RLI1
Translation initiation factor RLI1

2

3

High-throughput

0.621

High

799761

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.618

High

799749

SSB2
Ribosome-associated molecular chaperone SSB2

3

5

High-throughput

0.611

High

435054

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.611

High

799764

NOG1
Nucleolar GTP-binding protein 1

2

2

High-throughput

0.588

High

706968

TF2B
Transcription initiation factor IIB

3

2

High-throughput

0.587

High

579309

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

799752

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

6

High-throughput

0.584

High

799774

ATG9
Autophagy-related protein 9

2

1

High-throughput

0.567

High

799756

LSG1
Large subunit GTPase 1

2

0

High-throughput

0.563

High

799748

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

5

Small-scale

0.561

High

523797

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.552

High

526571

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

799758

PESC
Pescadillo homolog

2

1

High-throughput

0.537

High

435557

RS9B
Small ribosomal subunit protein uS4B

1

3

High-throughput

0.536

High

544705

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.536

High

554691

YPK1
Serine/threonine-protein kinase YPK1

1

4

High-throughput

0.536

High

689019

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.536

High

689204

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.536

High

689422

RS7A
Small ribosomal subunit protein eS7A

1

5

High-throughput

0.536

High

799755

RS7B
Small ribosomal subunit protein eS7B

1

5

High-throughput

0.536

High

799762

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.536

High

799776

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.536

High

670644

SIS1
Protein SIS1

1

5

High-throughput

0.515

High

432560

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.513

High

444505

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.513

High

688873

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.513

High

441359

KAPB
cAMP-dependent protein kinase type 2

1

4

Small-scale

0.501

High

622939

CSK22
Casein kinase II subunit alpha'

1

8

Small-scale

0.501

High

738632

EI2BB
Translation initiation factor eIF2B subunit beta

1

16

Small-scale

0.501

High

721899

XPO1
Exportin-1

1

7

High-throughput

0.489

High

410097

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

433609

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

435929

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

436396

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

441879

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

455031

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

503011

RS22A
Small ribosomal subunit protein uS8A

1

3

Small-scale

0.479

High

504182

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

511786

RS24A
Small ribosomal subunit protein eS24A

1

1

Small-scale

0.479

High

512066

RS4A
Small ribosomal subunit protein eS4A

1

2

High-throughput

0.479

High

512409

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

513855

RS11B
Small ribosomal subunit protein uS17B

1

3

High-throughput

0.479

High

513988

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

558693

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

679626

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

747330

RSSA1
Small ribosomal subunit protein uS2A

1

3

Small-scale

0.479

High

799745

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

799767

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

733768

ACH1
Acetyl-CoA hydrolase

1

0

High-throughput

0.458

High

799753

SCD6
Protein SCD6

1

0

Small-scale

0.458

High

656447

KC11
Casein kinase I homolog 1

1

2

Small-scale

0.457

High

531720

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.445

High

675966

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

742837

HSP79
Heat shock protein homolog SSE2

1

7

High-throughput

0.445

High

799751

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

751734

PRP8
Pre-mRNA-splicing factor 8

1

1

High-throughput

0.437

High

785910

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.437

High

794961

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

799742

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.437

High

799743

OTU2
OTU domain-containing protein 2

1

1

Small-scale

0.437

High

799759

COPA
Coatomer subunit alpha

1

3

High-throughput

0.437

High

799765

ESP1
Separin

1

1

High-throughput

0.437

High

799769

POB3
FACT complex subunit POB3

1

2

High-throughput

0.437

High

799775

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.437

High

434361

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.426

High

752202

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

799754

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

799772

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

6

High-throughput

0.407

High

694537

SPT5
Transcription elongation factor SPT5

2

0

High-throughput

0.307

High

799763

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

High-throughput

0.307

High

799760

KTR5
Probable mannosyltransferase KTR5

1

0

High-throughput

0.269

Low

780741

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

799757

VIR
Protein virilizer

1

0

High-throughput

0.249

Low

799773

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

799770

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025