Protein: CYAA
Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase)

Gene: CYAA, CYR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P08678

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004016 - adenylate cyclase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376203

RAS2
Ras-like protein 2

4

15

Small-scale

0.878

High

475105

PHO81
Phosphate system positive regulatory protein PHO81

2

4

High-throughput

0.802

High

475094

CYAA
Adenylate cyclase

2

18

High-throughput

0.791

High

475106

CAP
Adenylyl cyclase-associated protein

9

1

Small-scale

0.757

High

448603

SNF1
Carbon catabolite-derepressing protein kinase

1

3

Small-scale

0.724

High

475100

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

Small-scale

0.692

High

475108

DBF2
Cell cycle protein kinase DBF2

1

10

High-throughput

0.691

High

475138

VHS1
Serine/threonine-protein kinase VHS1

1

7

High-throughput

0.691

High

475134

ACT
Actin

3

3

High-throughput

0.667

High

392043

HSP82
ATP-dependent molecular chaperone HSP82

3

6

High-throughput

0.640

High

475098

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.633

High

475114

SWE1
Mitosis inhibitor protein kinase SWE1

1

20

High-throughput

0.618

High

475116

RM16
Large ribosomal subunit protein uL16m

2

1

High-throughput

0.588

High

475117

MAK5
ATP-dependent RNA helicase MAK5

2

3

High-throughput

0.588

High

475115

GBLP
Small ribosomal subunit protein RACK1

2

5

Small-scale

0.586

High

475131

PFD6
Prefoldin subunit 6

2

0

High-throughput

0.563

High

416843

CDC25
Cell division control protein 25

1

1

Small-scale

0.561

High

475136

COFI
Cofilin

1

1

High-throughput

0.536

High

475137

RLI1
Translation initiation factor RLI1

1

2

High-throughput

0.515

High

453870

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

475096

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

475103

HSP26
Heat shock protein 26

1

1

High-throughput

0.500

High

475118

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

5

High-throughput

0.489

High

405004

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.479

High

475104

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.479

High

475097

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.479

High

475102

HSC82
ATP-dependent molecular chaperone HSC82

1

6

Small-scale

0.479

High

475111

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

475122

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

475125

MPH1
ATP-dependent DNA helicase MPH1

1

3

High-throughput

0.479

High

475139

GIS1
Transcriptional activator/repressor GIS1

1

3

High-throughput

0.479

High

475143

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

475144

SGT1
Protein SGT1

1

14

Small-scale

0.479

High

475107

GBG
Guanine nucleotide-binding protein subunit gamma

1

0

Small-scale

0.460

High

475119

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

475129

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

475140

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

475095

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

475099

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

475101

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

475109

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

475120

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

475123

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

475133

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.445

High

475146

HSP42
Heat shock protein 42

1

2

High-throughput

0.445

High

475128

IML1
Vacuolar membrane-associated protein IML1

1

3

High-throughput

0.437

High

475145

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.437

High

475124

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

475126

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

475132

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

475130

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

High-throughput

0.407

High

475110

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.279

Low

475141

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

475147

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.279

Low

381800

H4
Histone H4

1

0

High-throughput

0.249

Low

475112

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

475121

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

475127

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

475135

H3
Histone H3

1

0

High-throughput

0.249

Low

475142

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

475113

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025