Protein: RN115
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)

Gene: RN115, RNF115
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q9Y4L5

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919917

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.964

High

849497

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

High-throughput

0.932

High

1377467

UB2D4
Ubiquitin-conjugating enzyme E2 D4

5

20

High-throughput

0.932

High

895967

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

High-throughput

0.911

High

1282368

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.861

High

476628

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

19

Small-scale

0.850

High

1284901

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.817

High

1297382

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.783

High

1377887

RN115
E3 ubiquitin-protein ligase RNF115

2

16

Small-scale

0.778

High

930473

UBC9
SUMO-conjugating enzyme UBC9

2

20

Small-scale

0.767

High

872236

RD23A
UV excision repair protein RAD23 homolog A

1

17

Small-scale

0.713

High

851913

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1065218

DAZP2
DAZ-associated protein 2

3

1

High-throughput

0.672

High

896575

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

845383

RAB7A
Ras-related protein Rab-7a

2

20

Small-scale

0.624

High

398150

ISG15
Ubiquitin-like protein ISG15

1

18

Small-scale

0.618

High

1201954

TAXB1
Tax1-binding protein 1

2

7

High-throughput

0.612

High

320071

HERC2
E3 ubiquitin-protein ligase HERC2

2

6

High-throughput

0.611

High

636533

DNJB2
DnaJ homolog subfamily B member 2

2

4

High-throughput

0.611

High

875473

TERA
Transitional endoplasmic reticulum ATPase

2

5

Small-scale

0.606

High

622717

ERD21
ER lumen protein-retaining receptor 1

2

0

High-throughput

0.602

High

683854

1433B
14-3-3 protein beta/alpha

2

13

Small-scale

0.584

High

918974

RAB1A
Ras-related protein Rab-1A

1

17

Small-scale

0.578

High

803824

BAG6
Large proline-rich protein BAG6

1

13

Small-scale

0.575

High

154454

GBRD
Gamma-aminobutyric acid receptor subunit delta

2

1

High-throughput

0.574

High

684424

1433S
14-3-3 protein sigma

1

13

Small-scale

0.573

High

169315

MDM4
Protein Mdm4

1

2

High-throughput

0.573

High

339191

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.561

High

348345

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.561

High

1203597

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.561

High

1273774

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

Small-scale

0.561

High

1284213

RAB7B
Ras-related protein Rab-7b

1

20

Small-scale

0.561

High

1304049

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.537

High

234311

PEPL
Periplakin

1

6

High-throughput

0.536

High

259900

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

3

High-throughput

0.536

High

271904

SPB7
Serpin B7

1

7

High-throughput

0.536

High

344354

AACT
Alpha-1-antichymotrypsin

1

7

High-throughput

0.536

High

397084

PAI2
Plasminogen activator inhibitor 2

1

7

High-throughput

0.536

High

428656

INVO
Involucrin

1

1

High-throughput

0.536

High

452296

HMOX1
Heme oxygenase 1

1

3

High-throughput

0.536

High

543088

GLNA
Glutamine synthetase

1

1

High-throughput

0.536

High

546912

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.536

High

577516

IL1RA
Interleukin-1 receptor antagonist protein

1

2

High-throughput

0.536

High

611370

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

668067

SPB3
Serpin B3

1

7

High-throughput

0.536

High

701703

DSG3
Desmoglein-3

1

4

High-throughput

0.536

High

776866

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.536

High

820412

SPB4
Serpin B4

1

6

High-throughput

0.536

High

871985

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

1036380

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

High-throughput

0.536

High

1064291

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.536

High

1197667

S1A7A
Protein S100-A7A

1

1

High-throughput

0.536

High

1203167

SPA9
Serpin A9

1

7

High-throughput

0.536

High

1204659

PA24D
Cytosolic phospholipase A2 delta

1

2

High-throughput

0.536

High

1271325

EVPL
Envoplakin

1

5

High-throughput

0.536

High

1271985

KLK6
Kallikrein-6

1

2

High-throughput

0.536

High

1317104

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

5

High-throughput

0.536

High

1349117

IL36G
Interleukin-36 gamma

1

2

High-throughput

0.536

High

1354029

I36RA
Interleukin-36 receptor antagonist protein

1

2

High-throughput

0.536

High

1355911

SPB13
Serpin B13

1

6

High-throughput

0.536

High

1355953

NAGK
N-acetyl-D-glucosamine kinase

1

2

High-throughput

0.536

High

120108

ST2B1
Sulfotransferase 2B1

1

0

High-throughput

0.513

High

311428

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.513

High

534006

ANXA8
Annexin A8

1

0

High-throughput

0.513

High

588464

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

787802

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

815060

LEG7
Galectin-7

1

0

High-throughput

0.513

High

835019

PSN2
Presenilin-2

1

0

High-throughput

0.513

High

965569

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

1001268

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.513

High

1075552

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1169320

ACP7
Acid phosphatase type 7

1

0

High-throughput

0.513

High

1271788

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1300252

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

1327974

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1357375

NDRG2
Protein NDRG2

1

0

High-throughput

0.513

High

396116

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

639832

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.501

High

682089

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.501

High

963038

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.501

High

134691

NPT3
Sodium-dependent phosphate transport protein 3

1

1

High-throughput

0.489

High

354796

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

6

High-throughput

0.489

High

648646

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

945765

NGAL
Neutrophil gelatinase-associated lipocalin

1

1

High-throughput

0.489

High

991953

SCN1B
Sodium channel subunit beta-1

1

1

High-throughput

0.489

High

1170258

R9BP
Regulator of G-protein signaling 9-binding protein

1

1

High-throughput

0.489

High

1224031

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1349439

CALL5
Calmodulin-like protein 5

1

3

High-throughput

0.489

High

349757

RASH
GTPase HRas

1

14

Small-scale

0.481

High

1068459

CDK10
Cyclin-dependent kinase 10

1

2

Small-scale

0.481

High

1231004

DOCK4
Dedicator of cytokinesis protein 4

1

1

Small-scale

0.481

High

120190

TLR4
Toll-like receptor 4

1

5

Small-scale

0.479

High

179973

TLR3
Toll-like receptor 3

1

5

Small-scale

0.479

High

538456

ENPL
Endoplasmin

1

3

Small-scale

0.479

High

592610

RAB5A
Ras-related protein Rab-5A

1

17

Small-scale

0.479

High

647420

1433T
14-3-3 protein theta

1

13

Small-scale

0.479

High

845895

RAB13
Ras-related protein Rab-13

1

15

Small-scale

0.479

High

905306

1433G
14-3-3 protein gamma

1

13

Small-scale

0.479

High

910204

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.479

High

927706

1433Z
14-3-3 protein zeta/delta

1

13

Small-scale

0.479

High

982661

1433F
14-3-3 protein eta

1

13

Small-scale

0.479

High

988167

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.479

High

1344385

TLR9
Toll-like receptor 9

1

4

Small-scale

0.479

High

1348547

TLR7
Toll-like receptor 7

1

5

Small-scale

0.479

High

1356383

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

344836

CYTC
Cystatin-C

1

0

Small-scale

0.460

High

869565

ATN1
Atrophin-1

1

0

Small-scale

0.460

High

971647

RL18A
Large ribosomal subunit protein eL20

1

0

Small-scale

0.460

High

555707

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

1328652

UN93B
Protein unc-93 homolog B1

1

0

Small-scale

0.458

High

1243044

GMCL2
Germ cell-less protein-like 2

1

2

High-throughput

0.445

High

875925

MFAP4
Microfibril-associated glycoprotein 4

1

1

Small-scale

0.439

High

72367

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

1166102

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

48919

IGLC7
Immunoglobulin lambda constant 7

1

10

High-throughput

0.407

High

66459

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

353746

IGHG1
Immunoglobulin heavy constant gamma 1

1

4

High-throughput

0.407

High

353835

IGHG2
Immunoglobulin heavy constant gamma 2

1

8

High-throughput

0.407

High

353866

IGHG3
Immunoglobulin heavy constant gamma 3

1

6

High-throughput

0.407

High

353901

IGHG4
Immunoglobulin heavy constant gamma 4

1

4

High-throughput

0.407

High

1190137

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.292

High

245857

CATL2
Cathepsin L2

1

0

High-throughput

0.279

Low

1078461

CH3L2
Chitinase-3-like protein 2

1

0

High-throughput

0.279

Low

1203310

FCSD1
F-BAR and double SH3 domains protein 1

1

0

High-throughput

0.279

Low

1262310

TMM40
Transmembrane protein 40

1

0

High-throughput

0.279

Low

1377869

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

363669

TTHY
Transthyretin

1

0

Small-scale

0.261

Low

783451

FOLR3
Folate receptor gamma

1

0

Small-scale

0.251

Low

1079808

EREP1
Endosomal transmembrane epsin interactor 1

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024