Protein: STX18
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)

Gene: STX18
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9P2W9

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005484 - SNAP receptor activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006886 - intracellular protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1358390

SCFD1
Sec1 family domain-containing protein 1

9

2

Small-scale

0.750

High

280363

SC22B
Vesicle-trafficking protein SEC22b

7

7

Small-scale

0.747

High

1238622

RINT1
RAD50-interacting protein 1

7

1

Small-scale

0.745

High

1452966

USE1
Vesicle transport protein USE1

6

1

Small-scale

0.736

High

1091997

SEC20
Vesicle transport protein SEC20

6

1

Small-scale

0.730

High

343495

SNP29
Synaptosomal-associated protein 29

5

3

High-throughput

0.716

High

211872

ZW10
Centromere/kinetochore protein zw10 homolog

8

0

Small-scale

0.716

High

60435

NBAS
NBAS subunit of NRZ tethering complex

7

0

Small-scale

0.714

High

933068

SNAA
Alpha-soluble NSF attachment protein

4

5

High-throughput

0.697

High

226243

STX6
Syntaxin-6

4

7

High-throughput

0.694

High

180091

BET1
BET1 homolog

4

5

High-throughput

0.691

High

1097912

STX5
Syntaxin-5

4

8

High-throughput

0.691

High

1454885

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

4

5

High-throughput

0.691

High

1454890

SRPRB
Signal recognition particle receptor subunit beta

5

0

High-throughput

0.686

High

1356296

SCFD2
Sec1 family domain-containing protein 2

4

0

High-throughput

0.667

High

189900

STX7
Syntaxin-7

3

7

High-throughput

0.667

High

278575

VAMP4
Vesicle-associated membrane protein 4

3

4

High-throughput

0.667

High

1294853

STX12
Syntaxin-12

3

7

High-throughput

0.667

High

1414886

VAMP8
Vesicle-associated membrane protein 8

3

5

High-throughput

0.667

High

1454889

STX8
Syntaxin-8

3

6

High-throughput

0.667

High

1210128

SNP47
Synaptosomal-associated protein 47

4

0

High-throughput

0.661

High

1418041

FUT8
Alpha-(1,6)-fucosyltransferase

4

0

High-throughput

0.661

High

630194

ACM3
Muscarinic acetylcholine receptor M3

2

1

High-throughput

0.628

High

1452700

BET1L
BET1-like protein

2

4

High-throughput

0.628

High

1407052

SNAG
Gamma-soluble NSF attachment protein

2

5

High-throughput

0.601

High

1111739

STIM1
Stromal interaction molecule 1

2

0

High-throughput

0.585

High

124121

SNP23
Synaptosomal-associated protein 23

2

3

Small-scale

0.571

High

951491

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

160921

STX16
Syntaxin-16

1

7

High-throughput

0.536

High

249907

STX10
Syntaxin-10

1

6

High-throughput

0.536

High

331930

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.536

High

857195

NSF
Vesicle-fusing ATPase

1

3

High-throughput

0.536

High

908059

VAMP7
Vesicle-associated membrane protein 7

1

9

High-throughput

0.536

High

1100731

STX3
Syntaxin-3

1

6

High-throughput

0.536

High

1154776

VAMP3
Vesicle-associated membrane protein 3

1

6

High-throughput

0.536

High

1383313

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

5

High-throughput

0.536

High

397123

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

130269

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

1086134

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1339370

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

0

High-throughput

0.513

High

1350095

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1382231

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1385286

TBC20
TBC1 domain family member 20

1

0

High-throughput

0.513

High

1452911

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.513

High

328756

VAMP5
Vesicle-associated membrane protein 5

1

5

High-throughput

0.489

High

1454884

UVRAG
UV radiation resistance-associated gene protein

1

0

Small-scale

0.479

High

48834

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

126852

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.479

High

374253

RASN
GTPase NRas

1

1

High-throughput

0.479

High

376048

RASK
GTPase KRas

1

1

High-throughput

0.479

High

466507

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

548381

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

581349

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

650465

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.479

High

902123

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

962590

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1015875

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

1087327

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1395978

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

1412709

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

791795

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

159898

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

174135

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

417822

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418490

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

540727

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

611402

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

699216

CALX
Calnexin

1

0

High-throughput

0.458

High

715822

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

847733

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

895129

EMD
Emerin

1

0

High-throughput

0.458

High

904177

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

982863

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1027226

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1058706

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1125718

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1249287

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1253003

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1309911

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1312620

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1334048

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1334605

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

1383136

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1401250

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1401723

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

1404257

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1414490

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1421171

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1431278

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.458

High

1431779

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1436349

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1452717

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1454852

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1251197

ZNT10
Calcium/manganese antiporter SLC30A10

1

3

High-throughput

0.445

High

1337992

ZNT7
Zinc transporter 7

1

3

High-throughput

0.445

High

1346815

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

3

High-throughput

0.445

High

1452203

S39A1
Zinc transporter ZIP1

1

1

High-throughput

0.445

High

464070

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

2

High-throughput

0.437

High

541735

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.437

High

704558

RXRB
Retinoic acid receptor RXR-beta

1

1

High-throughput

0.437

High

901642

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.437

High

1181553

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

1

High-throughput

0.437

High

1286945

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1430087

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.437

High

1448844

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

1279098

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

166435

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

3

High-throughput

0.407

High

704087

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

771257

APJ
Apelin receptor

1

1

High-throughput

0.407

High

1101689

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.407

High

1242966

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.407

High

329991

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

4

0

High-throughput

0.360

High

1451178

IFT57
Intraflagellar transport protein 57 homolog

4

0

High-throughput

0.360

High

1208761

CL12A
C-type lectin domain family 12 member A

3

0

High-throughput

0.347

High

1233882

RTL6
Retrotransposon Gag-like protein 6

3

0

High-throughput

0.347

High

191977

TEX28
Testis-specific protein TEX28

2

0

High-throughput

0.328

High

1357805

CC107
Coiled-coil domain-containing protein 107

2

0

High-throughput

0.328

High

1446715

TMM9B
Transmembrane protein 9B

2

0

High-throughput

0.313

High

1454886

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.313

High

1448517

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.307

High

248123

NUPR1
Nuclear protein 1

2

0

Small-scale

0.300

High

1395304

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

445277

S10A6
Protein S100-A6

1

0

High-throughput

0.279

Low

608002

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.279

Low

1102919

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.279

Low

1210015

TM201
Transmembrane protein 201

1

0

High-throughput

0.279

Low

1310489

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1383269

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.279

Low

1384579

RNF25
E3 ubiquitin-protein ligase RNF25

1

0

High-throughput

0.279

Low

1432440

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1454888

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.279

Low

696745

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769402

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

837887

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

939982

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.249

Low

1005199

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1100481

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1255914

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1323028

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1339745

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1412996

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

1434117

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1435398

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1448035

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

1448167

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1450123

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1453921

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1454887

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1233632

Q6IAL2
HMP19 protein

1

0

High-throughput

0.238

Low

870331

S6A12
Sodium- and chloride-dependent betaine transporter

1

0

High-throughput

0.232

Low

1031878

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.232

Low

1131642

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

1157205

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1236364

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1242261

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1404967

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1436005

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025