Protein: UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)

Gene: UB2L6, UBE2L6
Organism: Homo sapiens
Interactions: 120
UniProt ID: O14933

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168483

ARI2
E3 ubiquitin-protein ligase ARIH2

7

20

Small-scale

0.969

High

168540

LONF1
LON peptidase N-terminal domain and RING finger protein 1

4

20

High-throughput

0.911

High

168564

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

4

20

High-throughput

0.911

High

168557

RN125
E3 ubiquitin-protein ligase RNF125

3

20

Small-scale

0.876

High

168544

R144B
E3 ubiquitin-protein ligase RNF144B

3

20

Small-scale

0.873

High

168550

DTX3
Probable E3 ubiquitin-protein ligase DTX3

3

20

High-throughput

0.861

High

168565

TRIM8
E3 ubiquitin-protein ligase TRIM8

3

20

High-throughput

0.861

High

168476

PRKN
E3 ubiquitin-protein ligase parkin

3

20

Small-scale

0.847

High

48318

UBA6
Ubiquitin-like modifier-activating enzyme 6

2

20

Small-scale

0.799

High

168513

R144A
E3 ubiquitin-protein ligase RNF144A

2

20

Small-scale

0.791

High

168549

HERC6
Probable E3 ubiquitin-protein ligase HERC6

2

20

High-throughput

0.789

High

168470

TRI18
E3 ubiquitin-protein ligase Midline-1

2

20

High-throughput

0.783

High

168492

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

20

Small-scale

0.778

High

168503

UBA7
Ubiquitin-like modifier-activating enzyme 7

2

20

Small-scale

0.778

High

168527

UBE3A
Ubiquitin-protein ligase E3A

2

20

Small-scale

0.778

High

168559

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

High-throughput

0.768

High

168471

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

168542

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

13

High-throughput

0.698

High

168555

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

High-throughput

0.698

High

168556

RNF25
E3 ubiquitin-protein ligase RNF25

1

16

High-throughput

0.698

High

168567

RN122
RING finger protein 122

1

20

High-throughput

0.698

High

168570

TOPRS
E3 ubiquitin-protein ligase Topors

1

8

High-throughput

0.698

High

168577

RN150
RING finger protein 150

1

20

High-throughput

0.698

High

168578

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

High-throughput

0.698

High

168469

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

16

Small-scale

0.692

High

168543

RN19B
E3 ubiquitin-protein ligase RNF19B

1

20

Small-scale

0.690

High

168572

RN216
E3 ubiquitin-protein ligase RNF216

3

20

Small-scale

0.653

High

168478

TRI13
E3 ubiquitin-protein ligase TRIM13

1

20

Small-scale

0.647

High

168520

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

168560

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.647

High

168575

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.647

High

168524

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

High-throughput

0.621

High

131576

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

High-throughput

0.618

High

168480

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

14

Small-scale

0.618

High

168487

ISG15
Ubiquitin-like protein ISG15

1

20

High-throughput

0.618

High

168510

RBP2
E3 SUMO-protein ligase RanBP2

1

1

High-throughput

0.618

High

168523

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.618

High

168525

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

Small-scale

0.618

High

168531

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.618

High

168533

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.618

High

168534

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.618

High

168535

IMB1
Importin subunit beta-1

1

1

High-throughput

0.618

High

168541

SMU1
WD40 repeat-containing protein SMU1

1

11

High-throughput

0.618

High

168545

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.618

High

168552

COP1
E3 ubiquitin-protein ligase COP1

1

12

High-throughput

0.618

High

168558

OTUB1
Ubiquitin thioesterase OTUB1

1

13

Small-scale

0.618

High

168582

FBW1A
F-box/WD repeat-containing protein 1A

1

19

High-throughput

0.618

High

168583

ARI1
E3 ubiquitin-protein ligase ARIH1

1

20

Small-scale

0.618

High

168563

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

168561

MINT
Msx2-interacting protein

1

2

Small-scale

0.573

High

168551

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.553

High

168491

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

168529

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

13

High-throughput

0.541

High

168506

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.527

High

168521

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.515

High

168562

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

High-throughput

0.515

High

168553

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

High-throughput

0.513

High

168500

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

Small-scale

0.512

High

168530

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.501

High

168547

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

Small-scale

0.501

High

168514

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.486

High

168526

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.480

High

168473

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

20

Small-scale

0.479

High

168477

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

High-throughput

0.479

High

168479

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

168485

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

168488

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

168489

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

168490

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.479

High

168494

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.479

High

168495

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.479

High

168496

1433T
14-3-3 protein theta

1

4

High-throughput

0.479

High

168497

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

4

Small-scale

0.479

High

168498

RL12
Large ribosomal subunit protein uL11

1

1

High-throughput

0.479

High

168499

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

168502

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

168505

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

168509

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.479

High

168511

DYN2
Dynamin-2

1

1

High-throughput

0.479

High

168512

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.479

High

168515

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

168518

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

168519

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

168522

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

168528

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

168537

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.479

High

168546

TAXB1
Tax1-binding protein 1

1

6

High-throughput

0.479

High

168554

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.479

High

168566

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

168568

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

168571

RN19A
E3 ubiquitin-protein ligase RNF19A

1

20

Small-scale

0.479

High

168576

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

168580

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

168581

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

128616

MEN1
Menin

1

0

High-throughput

0.458

High

168472

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.458

High

168474

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

168481

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.458

High

168484

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

168493

COF1
Cofilin-1

1

0

High-throughput

0.458

High

168501

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

168508

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

168516

ACTZ
Alpha-centractin

1

0

High-throughput

0.458

High

168517

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

168532

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

168538

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

168569

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.458

High

168574

SEPT9
Septin-9

1

0

High-throughput

0.458

High

168579

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

168504

NAMPT
Nicotinamide phosphoribosyltransferase

1

1

Small-scale

0.457

High

168584

SNURF
SNRPN upstream reading frame protein

1

4

High-throughput

0.457

High

168482

WFS1
Wolframin

1

1

High-throughput

0.437

High

168486

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

168507

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.408

High

168548

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.279

Low

168475

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

Small-scale

0.249

Low

168536

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.249

Low

168539

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

168573

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025