Protein: PON2
Serum paraoxonase/arylesterase 2 (PON 2) (EC 3.1.1.2) (EC 3.1.1.81) (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)

Gene: PON2
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q15165

Gene Ontology (top 5):
GO:0004064 - arylesterase activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0009636 - response to toxic substance
GO:0042803 - protein homodimerization activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363309

EGFR
Epidermal growth factor receptor

4

3

High-throughput

0.694

High

320872

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

3

2

High-throughput

0.667

High

439739

INSR
Insulin receptor

3

2

High-throughput

0.667

High

565390

ITA4
Integrin alpha-4

3

1

High-throughput

0.667

High

654970

ITA6
Integrin alpha-6

3

1

High-throughput

0.667

High

1143724

ARSK
Arylsulfatase K

3

1

High-throughput

0.667

High

1143743

SULF2
Extracellular sulfatase Sulf-2

3

1

High-throughput

0.667

High

1143770

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

3

2

High-throughput

0.667

High

1143773

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

3

2

High-throughput

0.667

High

1143805

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

3

2

High-throughput

0.667

High

1143809

CATF
Cathepsin F

3

2

High-throughput

0.667

High

1143746

S39AB
Zinc transporter ZIP11

4

0

High-throughput

0.661

High

178271

NPC1
NPC intracellular cholesterol transporter 1

3

1

High-throughput

0.650

High

277013

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

3

0

High-throughput

0.638

High

535088

BIP
Endoplasmic reticulum chaperone BiP

3

0

High-throughput

0.638

High

1143732

LRP11
Low-density lipoprotein receptor-related protein 11

3

0

High-throughput

0.638

High

1143737

TM219
Insulin-like growth factor-binding protein 3 receptor

3

0

High-throughput

0.638

High

1143759

SPP2B
Signal peptide peptidase-like 2B

3

0

High-throughput

0.638

High

1143775

LMLN
Leishmanolysin-like peptidase

3

0

High-throughput

0.638

High

1143784

ABCA2
ATP-binding cassette sub-family A member 2

3

0

High-throughput

0.638

High

1143803

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.638

High

1143816

POMT2
Protein O-mannosyl-transferase 2

3

0

High-throughput

0.638

High

1089094

HYAL2
Hyaluronidase-2

3

0

High-throughput

0.634

High

1143736

GOLI
E3 ubiquitin-protein ligase RNF130

4

4

High-throughput

0.633

High

1143764

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

5

High-throughput

0.628

High

1143766

HMR1
Major histocompatibility complex class I-related protein 1

2

2

High-throughput

0.611

High

1143782

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

2

4

High-throughput

0.611

High

1143796

RN167
E3 ubiquitin-protein ligase RNF167

2

4

High-throughput

0.611

High

219809

CHSTA
Carbohydrate sulfotransferase 10

3

3

High-throughput

0.609

High

1143716

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

3

1

High-throughput

0.609

High

1143753

NETO2
Neuropilin and tolloid-like protein 2

3

1

High-throughput

0.609

High

1143755

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

3

5

High-throughput

0.609

High

1143797

CHSTC
Carbohydrate sulfotransferase 12

3

3

High-throughput

0.609

High

1143806

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

2

High-throughput

0.609

High

1143822

SIA10
Type 2 lactosamine alpha-2,3-sialyltransferase

3

5

High-throughput

0.609

High

1143763

DNS2B
Deoxyribonuclease-2-beta

2

0

High-throughput

0.602

High

1143776

NAR5
Ecto-ADP-ribosyltransferase 5

2

0

High-throughput

0.602

High

1143800

CNNM1
Metal transporter CNNM1

2

0

High-throughput

0.602

High

698678

CALX
Calnexin

3

1

High-throughput

0.593

High

327109

NXPH4
Neurexophilin-4

2

0

High-throughput

0.585

High

648279

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

2

0

High-throughput

0.585

High

1091809

TP4A2
Protein tyrosine phosphatase type IVA 2

2

0

High-throughput

0.585

High

1143761

SCRB1
Scavenger receptor class B member 1

2

0

High-throughput

0.585

High

1143804

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

2

0

High-throughput

0.585

High

139215

UPK2
Uroplakin-2

2

0

High-throughput

0.576

High

1143824

UST
Uronyl 2-sulfotransferase

2

2

High-throughput

0.574

High

1143734

AMGO1
Amphoterin-induced protein 1

2

5

High-throughput

0.558

High

154825

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

4

High-throughput

0.536

High

252941

UD19
UDP-glucuronosyltransferase 1A9

1

1

High-throughput

0.536

High

380427

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

4

High-throughput

0.536

High

380630

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

4

High-throughput

0.536

High

438885

CD1A
T-cell surface glycoprotein CD1a

1

3

High-throughput

0.536

High

520852

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

562725

BMP1
Bone morphogenetic protein 1

1

1

High-throughput

0.536

High

607373

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

2

High-throughput

0.536

High

641600

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

3

High-throughput

0.536

High

663546

CMA1
Chymase

1

3

High-throughput

0.536

High

688564

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

4

High-throughput

0.536

High

688665

NKG2C
NKG2-C type II integral membrane protein

1

4

High-throughput

0.536

High

788529

SCNNA
Epithelial sodium channel subunit alpha

1

5

High-throughput

0.536

High

908631

PRELP
Prolargin

1

1

High-throughput

0.536

High

1084042

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

5

High-throughput

0.536

High

1090091

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

4

High-throughput

0.536

High

1110343

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

High-throughput

0.536

High

1110445

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.536

High

1142057

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.536

High

1143765

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

1143767

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

1143771

ASIC4
Acid-sensing ion channel 4

1

5

High-throughput

0.536

High

1143812

CLC2D
C-type lectin domain family 2 member D

1

3

High-throughput

0.536

High

1143823

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

3

High-throughput

0.536

High

1143825

KLK5
Kallikrein-5

1

4

High-throughput

0.536

High

1143747

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

987654

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.518

High

680706

CATS
Cathepsin S

1

2

High-throughput

0.515

High

64357

CDHR4
Cadherin-related family member 4

1

0

High-throughput

0.513

High

184166

RER1
Protein RER1

1

0

High-throughput

0.513

High

230791

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

292633

RENR
Renin receptor

1

0

High-throughput

0.513

High

296614

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.513

High

376835

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.513

High

416616

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.513

High

548019

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

567867

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

787023

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.513

High

1092881

STRN3
Striatin-3

1

0

High-throughput

0.513

High

1113154

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1116988

LAMB3
Laminin subunit beta-3

1

0

High-throughput

0.513

High

1143725

ALKL2
ALK and LTK ligand 2

1

0

High-throughput

0.513

High

1143738

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1143748

PCD20
Protocadherin-20

1

0

High-throughput

0.513

High

1143781

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.513

High

1143814

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.513

High

1143817

CAH14
Carbonic anhydrase 14

1

0

High-throughput

0.513

High

191441

SIA8E
Alpha-2,8-sialyltransferase 8E

1

5

High-throughput

0.489

High

634758

GRAH
Granzyme H

1

3

High-throughput

0.489

High

1143718

CAHD1
VWFA and cache domain-containing protein 1

1

2

High-throughput

0.489

High

1143728

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

2

High-throughput

0.489

High

1143754

CHSTE
Carbohydrate sulfotransferase 14

1

3

High-throughput

0.489

High

1143757

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

2

High-throughput

0.489

High

1143789

CHST8
Carbohydrate sulfotransferase 8

1

3

High-throughput

0.489

High

1143790

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

1143819

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

5

High-throughput

0.489

High

188890

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

251087

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.479

High

458405

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

459293

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

582381

B4GT1
Beta-1,4-galactosyltransferase 1

1

1

High-throughput

0.479

High

928773

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

2

High-throughput

0.479

High

1143731

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1143735

CHSS1
Chondroitin sulfate synthase 1

1

3

High-throughput

0.479

High

1143794

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1143799

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1143802

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

218205

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

488793

FURIN
Furin

1

0

High-throughput

0.458

High

587473

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

633847

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

988380

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

1098400

DNJC3
DnaJ homolog subfamily C member 3

1

0

High-throughput

0.458

High

1126083

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

1143756

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1143820

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

1143826

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.458

High

701457

5HT2A
5-hydroxytryptamine receptor 2A

1

1

Small-scale

0.457

High

380545

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

3

High-throughput

0.445

High

467493

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.445

High

1060352

SLC31
Amino acid transporter heavy chain SLC3A1

1

1

High-throughput

0.445

High

1143783

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

1143791

S12A5
Solute carrier family 12 member 5

1

1

High-throughput

0.445

High

1143811

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.445

High

1143821

S22AE
Solute carrier family 22 member 14

1

1

High-throughput

0.445

High

1143726

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1143745

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1143752

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1143758

RDH11
Retinol dehydrogenase 11

1

1

High-throughput

0.437

High

1143760

RN128
E3 ubiquitin-protein ligase RNF128

1

4

High-throughput

0.437

High

1143762

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

4

High-throughput

0.437

High

219440

S26A4
Pendrin

1

0

High-throughput

0.426

High

332218

UCP5
Brain mitochondrial carrier protein 1

1

0

High-throughput

0.426

High

457453

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

653328

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1143720

SL9A4
Sodium/hydrogen exchanger 4

1

0

High-throughput

0.426

High

1143742

CTL2
Choline transporter-like protein 2

1

0

High-throughput

0.426

High

1143787

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

104153

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

170769

CLGN
Calmegin

1

1

High-throughput

0.407

High

1143721

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

1143740

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

1143739

C1QL4
Complement C1q-like protein 4

3

0

High-throughput

0.347

High

1143750

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

3

0

High-throughput

0.347

High

1143751

PGLT1
Protein O-glucosyltransferase 1

3

0

High-throughput

0.347

High

1143772

TXD15
Thioredoxin domain-containing protein 15

3

0

High-throughput

0.347

High

1143788

SIL1
Nucleotide exchange factor SIL1

3

0

High-throughput

0.347

High

1131658

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

0

High-throughput

0.318

High

1143723

MOXD1
DBH-like monooxygenase protein 1

2

0

High-throughput

0.318

High

1143744

UBR2
E3 ubiquitin-protein ligase UBR2

2

0

High-throughput

0.318

High

1143779

CDC6
Cell division control protein 6 homolog

2

0

High-throughput

0.318

High

1143792

SMOC1
SPARC-related modular calcium-binding protein 1

2

0

High-throughput

0.318

High

1143813

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

Small-scale

0.318

High

1143798

FBX6
F-box only protein 6

2

0

High-throughput

0.305

High

340133

PCNT
Pericentrin

1

0

High-throughput

0.279

Low

848778

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.279

Low

1143715

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

1143722

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

1143729

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.279

Low

1143733

ANR46
Ankyrin repeat domain-containing protein 46

1

0

High-throughput

0.279

Low

1143741

NNRD
ATP-dependent

1

0

High-throughput

0.279

Low

1143749

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.279

Low

1143768

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

1143777

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

0

High-throughput

0.279

Low

1143793

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

1143795

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1143815

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.279

Low

1143818

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.279

Low

404064

GCR
Glucocorticoid receptor

1

0

High-throughput

0.249

Low

650771

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.249

Low

830774

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

942625

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1143717

UVSSA
UV-stimulated scaffold protein A

1

0

Small-scale

0.249

Low

1143719

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1143727

PGAP1
GPI inositol-deacylase

1

0

High-throughput

0.249

Low

1143730

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

1143769

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

1143774

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.249

Low

1143780

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.249

Low

1143785

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

1143786

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1143807

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1143808

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

1143810

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

2101

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

330159

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1092543

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.232

Low

1143778

CNT3B
Contactin-associated protein-like 3B

1

0

High-throughput

0.232

Low

1143801

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025