Protein: SYNEM
Synemin (Desmuslin)

Gene: SYNEM, SYNM
Organism: Homo sapiens
Interactions: 65
UniProt ID: O15061

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005882 - intermediate filament
GO:0005912 - adherens junction
GO:0008307 - structural constituent of muscle
GO:0017166 - vinculin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176368

SYNCI
Syncoilin

2

20

High-throughput

0.811

High

176326

DESM
Desmin

2

20

Small-scale

0.799

High

176334

NEST
Nestin

1

20

High-throughput

0.691

High

176374

DNJB4
DnaJ homolog subfamily B member 4

4

3

High-throughput

0.633

High

176319

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

176320

VIME
Vimentin

1

20

High-throughput

0.618

High

176321

K1C19
Keratin, type I cytoskeletal 19

1

19

High-throughput

0.618

High

176325

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.618

High

176333

PERI
Peripherin

1

20

High-throughput

0.618

High

176360

CT55
Cancer/testis antigen 55

3

4

High-throughput

0.609

High

176335

AMPH
Amphiphysin

3

7

Small-scale

0.585

High

176352

CP135
Centrosomal protein of 135 kDa

3

20

High-throughput

0.578

High

176376

DTNA
Dystrobrevin alpha

1

10

Small-scale

0.573

High

176339

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.533

High

176318

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

13

High-throughput

0.526

High

176328

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

17

High-throughput

0.526

High

176350

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

16

High-throughput

0.526

High

176361

TITIN
Titin

1

20

Small-scale

0.506

High

176337

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.494

High

176327

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.489

High

176346

CUL4A
Cullin-4A

1

20

High-throughput

0.489

High

176357

CSN6
COP9 signalosome complex subunit 6

1

11

High-throughput

0.489

High

176351

ZYX
Zyxin

1

9

High-throughput

0.479

High

176347

FLNC
Filamin-C

1

12

Small-scale

0.457

High

176371

DISC1
Disrupted in schizophrenia 1 protein

1

3

Small-scale

0.457

High

176313

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

15

High-throughput

0.437

High

176315

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.437

High

176317

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.437

High

176322

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

13

Small-scale

0.437

High

176329

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.437

High

176330

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.437

High

176331

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

Small-scale

0.437

High

176336

EMD
Emerin

1

1

High-throughput

0.437

High

176338

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.437

High

176340

ARF5
ADP-ribosylation factor 5

1

5

High-throughput

0.437

High

176341

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

12

Small-scale

0.437

High

176342

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.437

High

176343

FOXO1
Forkhead box protein O1

1

5

High-throughput

0.437

High

176348

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.437

High

176349

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.437

High

176353

RNF43
E3 ubiquitin-protein ligase RNF43

1

16

High-throughput

0.437

High

176355

SYNE3
Nesprin-3

1

15

High-throughput

0.437

High

176356

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

176358

SLN11
Schlafen family member 11

1

1

High-throughput

0.437

High

176359

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

11

High-throughput

0.437

High

176363

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.437

High

176365

SH3G2
Endophilin-A1

1

20

Small-scale

0.437

High

176366

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.437

High

176367

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

6

Small-scale

0.437

High

176369

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

15

High-throughput

0.437

High

176370

ANLN
Anillin

1

18

High-throughput

0.437

High

176372

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

176314

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.407

High

176323

CFTR
Cystic fibrosis transmembrane conductance regulator

1

20

High-throughput

0.407

High

176332

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.407

High

176344

CTBP1
C-terminal-binding protein 1

1

11

High-throughput

0.407

High

176364

ZBT18
Zinc finger and BTB domain-containing protein 18

1

10

High-throughput

0.407

High

176373

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.407

High

176375

ITM2B
Integral membrane protein 2B

1

10

High-throughput

0.407

High

176316

CEP43
Centrosomal protein 43

1

0

High-throughput

0.279

Low

176362

SKA1
SKA complex subunit 1

1

0

High-throughput

0.279

Low

176312

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

176324

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

Small-scale

0.249

Low

176345

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

176354

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025