Protein: PKHN1
Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)

Gene: PKHN1, PLEKHN1
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q494U1

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001786 - phosphatidylserine binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1093835

TRAF1
TNF receptor-associated factor 1

4

2

High-throughput

0.698

High

1193117

TAXB1
Tax1-binding protein 1

4

2

High-throughput

0.698

High

878476

PAXI
Paxillin

4

9

High-throughput

0.689

High

253961

LPXN
Leupaxin

3

10

High-throughput

0.675

High

1048868

REL
Proto-oncogene c-Rel

4

0

High-throughput

0.668

High

1095661

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

1

High-throughput

0.665

High

1115526

ASPP2
Apoptosis-stimulating of p53 protein 2

2

5

High-throughput

0.633

High

927331

ATX1
Ataxin-1

3

0

High-throughput

0.632

High

250254

VINEX
Vinexin

2

2

High-throughput

0.606

High

300576

KRT36
Keratin, type I cuticular Ha6

2

3

High-throughput

0.606

High

930713

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.606

High

1007481

KRT83
Keratin, type II cuticular Hb3

2

1

High-throughput

0.606

High

1145958

K1H1
Keratin, type I cuticular Ha1

2

2

High-throughput

0.606

High

1151523

TRIP6
Thyroid receptor-interacting protein 6

2

9

High-throughput

0.606

High

1193126

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

1

High-throughput

0.606

High

1193131

PDLI7
PDZ and LIM domain protein 7

2

9

High-throughput

0.606

High

1193134

ABI2
Abl interactor 2

2

8

High-throughput

0.606

High

1193138

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.606

High

1193109

ELP2
Elongator complex protein 2

2

1

High-throughput

0.601

High

1186623

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1186823

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.580

High

1193105

PPM1J
Protein phosphatase 1J

2

0

High-throughput

0.580

High

1193115

ZN438
Zinc finger protein 438

2

0

High-throughput

0.580

High

1193119

KRA13
Keratin-associated protein 1-3

2

0

High-throughput

0.580

High

1193135

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

327602

ELP1
Elongator complex protein 1

2

0

High-throughput

0.576

High

1193127

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.573

High

885266

HXA1
Homeobox protein Hox-A1

2

1

High-throughput

0.553

High

1193106

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.553

High

1193108

FHL5
Four and a half LIM domains protein 5

2

9

High-throughput

0.553

High

572003

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.549

High

1193107

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

1

High-throughput

0.536

High

1193113

TAOK1
Serine/threonine-protein kinase TAO1

1

6

High-throughput

0.536

High

1193137

KLH42
Kelch-like protein 42

1

4

High-throughput

0.536

High

1193118

RFX6
DNA-binding protein RFX6

1

1

High-throughput

0.523

High

507215

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

1193125

OPALI
Opalin

1

0

High-throughput

0.513

High

1193129

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

1193104

PKHN1
Pleckstrin homology domain-containing family N member 1

1

4

High-throughput

0.481

High

701159

PSB5
Proteasome subunit beta type-5

1

1

Small-scale

0.479

High

1022724

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.479

High

1193136

PAK5
Serine/threonine-protein kinase PAK 5

1

11

Small-scale

0.479

High

517012

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

1053241

Q05BL1
TP53BP2 protein

1

5

High-throughput

0.470

High

374642

RASH
GTPase HRas

1

0

High-throughput

0.458

High

1106782

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

0

Small-scale

0.458

High

1144929

RAB35
Ras-related protein Rab-35

1

0

Small-scale

0.458

High

1193132

RN216
E3 ubiquitin-protein ligase RNF216

1

0

Small-scale

0.458

High

1193140

NEMO
NF-kappa-B essential modulator

1

0

Small-scale

0.458

High

527

NBPFJ
NBPF family member NBPF19

1

2

High-throughput

0.439

High

1180430

PRIC4
Prickle-like protein 4

1

10

High-throughput

0.439

High

1193114

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.439

High

1193110

BRWD3
Bromodomain and WD repeat-containing protein 3

1

1

High-throughput

0.437

High

1193124

BIRC8
Baculoviral IAP repeat-containing protein 8

1

1

Small-scale

0.437

High

1193128

NAA60
N-alpha-acetyltransferase 60

1

2

Small-scale

0.437

High

1193120

CBY2
Protein chibby homolog 2

3

0

High-throughput

0.352

High

587095

ITF2
Transcription factor 4

2

0

High-throughput

0.327

High

70240

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1044651

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.316

High

1193111

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1193116

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

1193121

IKBD
NF-kappa-B inhibitor delta

2

0

High-throughput

0.316

High

1193130

ZC4H2
Zinc finger C4H2 domain-containing protein

2

0

High-throughput

0.316

High

1193133

PIHD1
PIH1 domain-containing protein 1

2

0

High-throughput

0.316

High

1193139

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.316

High

1193122

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.251

Low

1017778

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

1193112

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.232

Low

1193123

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025