Protein: SP130
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)

Gene: SP130, SAP130
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q9H0E3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0016607 - nuclear speck
GO:0030336 - negative regulation of cell migration
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110061

HDAC1
Histone deacetylase 1

8

9

Small-scale

0.750

High

1368106

HDAC2
Histone deacetylase 2

5

9

Small-scale

0.712

High

1158995

RBBP7
Histone-binding protein RBBP7

4

10

High-throughput

0.691

High

1429908

SHCAF
SIN3-HDAC complex-associated factor

4

2

Small-scale

0.691

High

274377

SIN3B
Paired amphipathic helix protein Sin3b

3

7

High-throughput

0.667

High

1050751

MAD1
Max dimerization protein 1

3

11

High-throughput

0.667

High

1429903

ING2
Inhibitor of growth protein 2

3

10

Small-scale

0.667

High

282305

SAP30
Histone deacetylase complex subunit SAP30

3

3

High-throughput

0.656

High

872728

SOX2
Transcription factor SOX-2

3

18

Small-scale

0.656

High

1252855

ZN704
Zinc finger protein 704

3

0

High-throughput

0.634

High

959652

MAX
Protein max

2

10

High-throughput

0.628

High

1029751

FOXK2
Forkhead box protein K2

2

13

Small-scale

0.628

High

1414385

PHF23
PHD finger protein 23

2

0

High-throughput

0.602

High

1066483

RBBP4
Histone-binding protein RBBP4

2

8

High-throughput

0.601

High

1428245

TGIF2
Homeobox protein TGIF2

2

5

High-throughput

0.601

High

1429915

DAXX
Death domain-associated protein 6

2

1

High-throughput

0.601

High

373109

MYC
Myc proto-oncogene protein

2

12

Small-scale

0.595

High

260434

BRD4
Bromodomain-containing protein 4

2

8

High-throughput

0.584

High

474274

NFIC
Nuclear factor 1 C-type

2

18

High-throughput

0.584

High

1115415

CUL4B
Cullin-4B

2

14

Small-scale

0.584

High

1133650

NFIX
Nuclear factor 1 X-type

2

18

High-throughput

0.584

High

1195598

ARI4B
AT-rich interactive domain-containing protein 4B

2

11

Small-scale

0.584

High

1429905

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

2

7

Small-scale

0.584

High

1415797

MAD3
Max dimerization protein 3

2

11

High-throughput

0.574

High

1094417

CSN1
COP9 signalosome complex subunit 1

1

2

Small-scale

0.561

High

1357148

GATD1
GATA zinc finger domain-containing protein 1

2

0

High-throughput

0.559

High

331309

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.536

High

384541

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.536

High

711790

ARI4A
AT-rich interactive domain-containing protein 4A

1

9

High-throughput

0.536

High

1017486

FOXK1
Forkhead box protein K1

1

14

High-throughput

0.536

High

1123104

FHL2
Four and a half LIM domains protein 2

1

13

High-throughput

0.536

High

1307258

TF2LX
Homeobox protein TGIF2LX

1

6

High-throughput

0.536

High

1429909

PRDM5
PR domain zinc finger protein 5

1

1

High-throughput

0.536

High

1429918

ING1
Inhibitor of growth protein 1

1

13

High-throughput

0.536

High

1429922

TPX2
Targeting protein for Xklp2

1

4

High-throughput

0.536

High

1429921

HECD1
E3 ubiquitin-protein ligase HECTD1

2

9

High-throughput

0.533

High

1112986

CUL2
Cullin-2

1

14

Small-scale

0.512

High

1014610

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.508

High

1371678

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.501

High

907114

CCR9
C-C chemokine receptor type 9

1

1

High-throughput

0.494

High

630355

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

3

High-throughput

0.489

High

129411

MEN1
Menin

1

4

High-throughput

0.479

High

143243

NFIB
Nuclear factor 1 B-type

1

13

High-throughput

0.479

High

181560

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

194339

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

210344

PHF1
PHD finger protein 1

1

6

High-throughput

0.479

High

248344

HBP1
HMG box-containing protein 1

1

16

High-throughput

0.479

High

285465

EED
Polycomb protein EED

1

13

High-throughput

0.479

High

286069

SF3B1
Splicing factor 3B subunit 1

1

6

Small-scale

0.479

High

316981

MTA2
Metastasis-associated protein MTA2

1

9

High-throughput

0.479

High

339849

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

352242

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

378519

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

465038

SP1
Transcription factor Sp1

1

10

High-throughput

0.479

High

519562

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

520360

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

520634

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

591834

H2AX
Histone H2AX

1

7

High-throughput

0.479

High

607094

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

635216

HNF1A
Hepatocyte nuclear factor 1-alpha

1

7

High-throughput

0.479

High

662274

PAX7
Paired box protein Pax-7

1

17

High-throughput

0.479

High

662496

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

685342

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

703375

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

11

High-throughput

0.479

High

714413

PML
Protein PML

1

10

Small-scale

0.479

High

725315

TLX1
T-cell leukemia homeobox protein 1

1

15

High-throughput

0.479

High

775906

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776126

SOX5
Transcription factor SOX-5

1

18

High-throughput

0.479

High

776245

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

822858

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

834048

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

862438

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

879452

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

887208

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.479

High

944734

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.479

High

980294

H4
Histone H4

1

8

High-throughput

0.479

High

986707

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

1017196

H33
Histone H3.3

1

16

Small-scale

0.479

High

1032044

TFAP4
Transcription factor AP-4

1

2

Small-scale

0.479

High

1048092

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.479

High

1052911

HME1
Homeobox protein engrailed-1

1

7

High-throughput

0.479

High

1086816

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1088001

NFIA
Nuclear factor 1 A-type

1

19

High-throughput

0.479

High

1088555

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.479

High

1089012

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

1094731

CAF1A
Chromatin assembly factor 1 subunit A

1

4

High-throughput

0.479

High

1095101

KLF10
Krueppel-like factor 10

1

9

High-throughput

0.479

High

1097550

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

1102646

MTA1
Metastasis-associated protein MTA1

1

9

High-throughput

0.479

High

1112706

CUL1
Cullin-1

1

14

Small-scale

0.479

High

1115048

CUL4A
Cullin-4A

1

14

Small-scale

0.479

High

1118680

KLF9
Krueppel-like factor 9

1

16

High-throughput

0.479

High

1152737

ELF2
ETS-related transcription factor Elf-2

1

12

High-throughput

0.479

High

1157920

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

1208642

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

7

High-throughput

0.479

High

1218899

TAF3
Transcription initiation factor TFIID subunit 3

1

11

Small-scale

0.479

High

1276767

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1295302

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.479

High

1313420

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1351154

SP7
Transcription factor Sp7

1

16

High-throughput

0.479

High

1351286

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

8

High-throughput

0.479

High

1361005

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.479

High

1367228

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1370366

CSN5
COP9 signalosome complex subunit 5

1

9

Small-scale

0.479

High

1398769

PWP2A
PWWP domain-containing protein 2A

1

5

High-throughput

0.479

High

1401385

CIC
Protein capicua homolog

1

19

High-throughput

0.479

High

1403014

SIN3A
Paired amphipathic helix protein Sin3a

1

7

Small-scale

0.479

High

1413339

MTA3
Metastasis-associated protein MTA3

1

10

High-throughput

0.479

High

1416902

KLF16
Krueppel-like factor 16

1

16

High-throughput

0.479

High

1421341

BC11B
B-cell lymphoma/leukemia 11B

1

4

High-throughput

0.479

High

1429904

BC11A
BCL11 transcription factor A

1

4

High-throughput

0.479

High

1429906

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1429910

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1429912

ZN219
Zinc finger protein 219

1

1

High-throughput

0.479

High

1429913

MBD2
Methyl-CpG-binding domain protein 2

1

3

High-throughput

0.479

High

1429917

KLF15
Krueppel-like factor 15

1

17

High-throughput

0.479

High

1429920

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

1429923

ASF1A
Histone chaperone ASF1A

1

4

High-throughput

0.479

High

1429924

MTF2
Metal-response element-binding transcription factor 2

1

6

High-throughput

0.479

High

155351

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

168321

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

283623

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

1352592

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

1392569

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.458

High

1429911

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

133878

FOXN3
Forkhead box protein N3

1

12

High-throughput

0.445

High

982818

RS24
Small ribosomal subunit protein eS24

1

3

High-throughput

0.445

High

1007781

RAE1L
mRNA export factor RAE1

1

10

High-throughput

0.445

High

1089857

ILF3
Interleukin enhancer-binding factor 3

1

11

High-throughput

0.445

High

605529

SYN1
Synapsin-1

1

10

High-throughput

0.437

High

895043

EMD
Emerin

1

3

Small-scale

0.437

High

938500

PAX9
Paired box protein Pax-9

1

14

High-throughput

0.437

High

1063604

GOGA2
Golgin subfamily A member 2

1

9

High-throughput

0.437

High

1135275

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

15

High-throughput

0.437

High

1216628

LIN9
Protein lin-9 homolog

1

3

High-throughput

0.437

High

1339171

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.437

High

1396125

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.437

High

1415861

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.437

High

1429916

HMGX4
HMG domain-containing protein 4

1

17

High-throughput

0.437

High

1429919

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.437

High

1091650

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.426

High

1429907

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1397243

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

1429914

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

842532

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.249

Low

991930

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1147273

ELOB
Elongin-B

1

0

Small-scale

0.249

Low

1312690

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025