Protein: SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin (EC 3.4.24.-) (EC 3.6.-.-) (Cell matrix adhesion regulator) (Paraplegin) (Spastic paraplegia 7 protein)

Gene: SPG7
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q9UQ90

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1242332

PNMA1
Paraneoplastic antigen Ma1

4

2

High-throughput

0.642

High

1357862

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

3

0

High-throughput

0.629

High

904194

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

3

High-throughput

0.616

High

146427

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

1

High-throughput

0.609

High

1127213

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.584

High

1189489

NT2NA
Notch homolog 2 N-terminal-like protein A

2

4

High-throughput

0.578

High

380158

MAS
Proto-oncogene Mas

2

6

High-throughput

0.574

High

723437

APJ
Apelin receptor

2

3

High-throughput

0.574

High

1233372

SESQ1
Sesquipedalian-1

2

6

High-throughput

0.574

High

1305560

LPAR4
Lysophosphatidic acid receptor 4

2

6

High-throughput

0.574

High

1357860

GPR55
G-protein coupled receptor 55

2

10

High-throughput

0.558

High

1030029

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.541

High

164038

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.536

High

198168

MSH5
MutS protein homolog 5

1

2

High-throughput

0.536

High

726475

BASI
Basigin

1

3

High-throughput

0.536

High

1068120

PDK1
[Pyruvate dehydrogenase

1

4

High-throughput

0.536

High

1267497

AP3S1
AP-3 complex subunit sigma-1

1

5

High-throughput

0.536

High

1274555

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

4

High-throughput

0.536

High

1282245

HDA10
Polyamine deacetylase HDAC10

1

5

High-throughput

0.536

High

1327067

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.536

High

207848

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

1

High-throughput

0.523

High

889435

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.523

High

889922

KR109
Keratin-associated protein 10-9

1

3

High-throughput

0.523

High

1149401

K1C40
Keratin, type I cytoskeletal 40

1

7

High-throughput

0.523

High

1310223

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.523

High

170165

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

317777

STABP
STAM-binding protein

1

0

High-throughput

0.518

High

271950

FCN3
Ficolin-3

1

0

High-throughput

0.513

High

1253816

CERK1
Ceramide kinase

1

0

High-throughput

0.513

High

1254689

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1264036

CBPA5
Carboxypeptidase A5

1

0

High-throughput

0.513

High

1318921

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

0

High-throughput

0.513

High

1085549

MK06
Mitogen-activated protein kinase 6

1

8

High-throughput

0.508

High

673770

BKRB2
B2 bradykinin receptor

1

5

High-throughput

0.494

High

1309038

KR412
Keratin-associated protein 4-12

1

3

High-throughput

0.494

High

156960

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.489

High

172290

GP182
G-protein coupled receptor 182

1

6

High-throughput

0.489

High

198138

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

354909

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

505503

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

4

High-throughput

0.489

High

538824

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

4

High-throughput

0.489

High

792867

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.489

High

813991

GPR12
G-protein coupled receptor 12

1

1

High-throughput

0.489

High

895757

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.489

High

933668

TBA4A
Tubulin alpha-4A chain

1

9

High-throughput

0.489

High

968949

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.489

High

1044467

PTC1
Protein patched homolog 1

1

5

High-throughput

0.489

High

1062713

EMC2
ER membrane protein complex subunit 2

1

5

High-throughput

0.489

High

1183431

SV2A
Synaptic vesicle glycoprotein 2A

1

4

High-throughput

0.489

High

1202760

P2RY8
P2Y purinoceptor 8

1

6

High-throughput

0.489

High

1217757

S22A9
Organic anion transporter 7

1

3

High-throughput

0.489

High

1233071

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.489

High

1254417

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

3

High-throughput

0.489

High

1297052

MRGX4
Mas-related G-protein coupled receptor member X4

1

4

High-throughput

0.489

High

1347734

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.489

High

1357143

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.489

High

1357861

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

1066888

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1172303

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1262405

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

1

High-throughput

0.479

High

1269950

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

484738

NT2NC
Notch homolog 2 N-terminal-like protein C

1

4

High-throughput

0.470

High

642182

KRA59
Keratin-associated protein 5-9

1

4

High-throughput

0.464

High

889029

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

951464

RHOG
Rho-related GTP-binding protein RhoG

1

15

High-throughput

0.437

High

1101382

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1201769

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

1263283

5HT3C
5-hydroxytryptamine receptor 3C

1

1

High-throughput

0.437

High

1287223

FAF2
FAS-associated factor 2

1

16

High-throughput

0.437

High

1310268

CAB45
45 kDa calcium-binding protein

1

3

High-throughput

0.437

High

1331648

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1355333

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

Small-scale

0.437

High

1137594

RIF1
Telomere-associated protein RIF1

1

2

High-throughput

0.417

High

1306294

MDFI
MyoD family inhibitor

4

0

High-throughput

0.368

High

1145417

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

0

High-throughput

0.328

High

1253060

F174A
Membrane protein FAM174A

2

0

High-throughput

0.328

High

67402

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

253230

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

310249

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.299

High

899084

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.299

High

1139271

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.299

High

1274279

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.299

High

1115457

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.282

High

1356525

RALY
RNA-binding protein Raly

1

0

High-throughput

0.282

High

64075

AQ12B
Aquaporin-12B

1

0

High-throughput

0.279

Low

212297

ITM2A
Integral membrane protein 2A

1

0

High-throughput

0.279

Low

245444

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

439196

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

442921

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

0

High-throughput

0.279

Low

516177

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

814317

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

1168215

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1185651

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

1198901

ACOT1
Acyl-coenzyme A thioesterase 1

1

0

High-throughput

0.279

Low

1266064

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1290250

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1291365

PGAP3
Post-GPI attachment to proteins factor 3

1

0

High-throughput

0.279

Low

1293451

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1312519

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

1357460

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

0

High-throughput

0.279

Low

1357859

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

655

NBPFJ
Neuroblastoma breakpoint family member 19

1

0

High-throughput

0.251

Low

299133

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.251

Low

1133141

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

944636

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.249

Low

1037212

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

High-throughput

0.249

Low

1295251

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024