Protein: VATC
V-type proton ATPase subunit C (V-ATPase subunit C) (V-ATPase 42 kDa subunit) (Vacuolar proton pump subunit C)

Gene: VATC, VMA5
Organism: Saccharomyces cerevisiae S288C
Interactions: 89
UniProt ID: P31412

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain
GO:0000329 - fungal-type vacuole membrane
GO:0005524 - ATP binding
GO:0007035 - vacuolar acidification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645801

VATE
V-type proton ATPase subunit E

7

4

Small-scale

0.956

High

726553

VPP1
V-type proton ATPase subunit a, vacuolar isoform

6

12

Small-scale

0.943

High

726582

VATG
V-type proton ATPase subunit G

6

4

Small-scale

0.928

High

726551

VA0D
V-type proton ATPase subunit d

3

3

Small-scale

0.837

High

726572

VATH
V-type proton ATPase subunit H

3

1

Small-scale

0.820

High

592080

VATB
V-type proton ATPase subunit B

6

7

Small-scale

0.730

High

603428

VATA
V-type proton ATPase catalytic subunit A

6

13

Small-scale

0.727

High

726554

VATD
V-type proton ATPase subunit D

5

3

Small-scale

0.713

High

726555

VATL2
V-type proton ATPase subunit c'

2

0

Small-scale

0.690

High

726579

RAV1
Regulator of V-ATPase in vacuolar membrane protein 1

3

3

Small-scale

0.670

High

726590

RAV2
Regulator of V-ATPase in vacuolar membrane protein 2

4

0

Small-scale

0.669

High

726559

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

12

Small-scale

0.665

High

726567

VATF
V-type proton ATPase subunit F

3

3

Small-scale

0.648

High

726599

NYV1
Vacuolar v-SNARE NYV1

2

1

High-throughput

0.586

High

726595

RTC5
Restriction of telomere capping protein 5

1

0

High-throughput

0.586

High

726570

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

726598

GET3
ATPase GET3

1

0

High-throughput

0.518

High

726580

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

2

High-throughput

0.501

High

726600

PRR2
Serine/threonine-protein kinase PRR2

1

1

High-throughput

0.501

High

726602

SKS1
Serine/threonine-protein kinase SKS1

1

1

High-throughput

0.501

High

726131

2AAA
Protein phosphatase PP2A regulatory subunit A

1

1

High-throughput

0.494

High

392382

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

518236

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

579006

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

682196

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.479

High

726578

VTC4
Vacuolar transporter chaperone complex subunit 4

1

1

High-throughput

0.479

High

726588

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

1

High-throughput

0.479

High

726601

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

726550

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.460

High

547032

PPB
Repressible alkaline phosphatase

1

0

High-throughput

0.458

High

679462

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

726549

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

726552

YBT1
ATP-dependent bile acid permease

1

0

High-throughput

0.458

High

726560

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

726562

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.458

High

726568

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

726585

VSB1
Vacuolar basic amino acid transporter VSB1

1

0

High-throughput

0.458

High

726589

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.458

High

726593

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

726594

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

726596

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

523307

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

544106

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

509441

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

High-throughput

0.437

High

509881

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

2

High-throughput

0.437

High

670439

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

726548

VATC
V-type proton ATPase subunit C

1

4

Small-scale

0.408

High

726573

GSHR
Glutathione reductase

1

0

High-throughput

0.282

High

633449

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.279

Low

726566

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

726571

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.279

Low

726591

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

517946

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

577061

SEC63
Protein translocation protein SEC63

1

0

Small-scale

0.251

Low

726556

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

726561

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

726574

GZF3
Protein GZF3

1

0

High-throughput

0.251

Low

726577

TAF1
Transcription initiation factor TFIID subunit 1

1

0

High-throughput

0.251

Low

149641

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383577

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

409989

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433508

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

434910

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435836

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441766

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

502905

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504091

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

558627

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

647033

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

674473

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689320

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

706440

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

726557

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

726558

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

726563

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

726564

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

726565

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

726569

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

726575

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

726576

RMD8
Sporulation protein RMD8

1

0

High-throughput

0.249

Low

726581

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

726584

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

726586

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

726587

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

726592

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

726597

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

726583

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low

726603

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025