Protein: LEO1
RNA polymerase-associated protein LEO1

Gene: LEO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 68
UniProt ID: P38439

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0006325 - chromatin organization
GO:0006353 - DNA-templated transcription termination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798594

PAF1
RNA polymerase II-associated protein 1

11

8

Small-scale

0.977

High

800265

CTR9
RNA polymerase-associated protein CTR9

13

6

Small-scale

0.760

High

800275

CDC73
Cell division control protein 73

12

3

Small-scale

0.759

High

800258

RTF1
RNA polymerase-associated protein RTF1

11

2

Small-scale

0.758

High

800270

POB3
FACT complex subunit POB3

8

1

Small-scale

0.747

High

739617

SPT16
FACT complex subunit SPT16

10

0

Small-scale

0.721

High

800247

LEO1
RNA polymerase-associated protein LEO1

1

1

High-throughput

0.665

High

594347

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

2

Small-scale

0.646

High

470518

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.614

High

454571

TFS2
Transcription elongation factor S-II

2

2

Small-scale

0.602

High

670645

SIS1
Protein SIS1

2

1

High-throughput

0.601

High

800264

H3
Histone H3

2

2

Small-scale

0.595

High

694538

SPT5
Transcription elongation factor SPT5

1

2

Small-scale

0.554

High

793415

ATR
Serine/threonine-protein kinase MEC1

1

0

Small-scale

0.537

High

800261

ELOA1
Elongin-A

1

0

Small-scale

0.537

High

750932

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

Small-scale

0.515

High

800267

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

Small-scale

0.506

High

401988

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.501

High

438533

UBC2
Ubiquitin-conjugating enzyme E2 2

1

3

Small-scale

0.501

High

441117

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

585921

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

656448

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.501

High

656763

KC12
Casein kinase I homolog 2

1

2

High-throughput

0.501

High

744293

CHD1
Chromo domain-containing protein 1

1

4

Small-scale

0.501

High

748830

SWE1
Mitosis inhibitor protein kinase SWE1

1

1

High-throughput

0.501

High

800248

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

448706

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.480

High

364501

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

382072

H4
Histone H4

1

3

High-throughput

0.479

High

679627

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

706969

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

708726

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.479

High

734952

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

743087

STH1
Nuclear protein STH1/NPS1

1

3

Small-scale

0.479

High

800249

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

1

Small-scale

0.479

High

800252

RAD26
DNA repair and recombination protein RAD26

1

6

Small-scale

0.479

High

800253

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

800260

INO80
Chromatin-remodeling ATPase INO80

1

5

Small-scale

0.479

High

800263

ARP5
Actin-related protein 5

1

2

Small-scale

0.479

High

800269

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

800272

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

800278

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.479

High

800279

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.479

High

436397

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

645161

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.458

High

677371

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

800255

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

800256

CLA4
Serine/threonine-protein kinase CLA4

1

0

Small-scale

0.458

High

800262

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

800271

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.458

High

800273

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.458

High

800274

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

800277

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

523798

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

526572

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

544706

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

796390

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.438

High

800250

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

800266

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

800251

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

692343

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

800259

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

800268

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

0

High-throughput

0.261

Low

800254

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

800276

CRT10
Protein CRT10

1

0

Small-scale

0.249

Low

797941

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

800257

GNP1
High-affinity glutamine permease

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025