Protein: RIR3
Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2)

Gene: RIR3, RNR3
Organism: Saccharomyces cerevisiae S288C
Interactions: 57
UniProt ID: P21672

Gene Ontology (top 5):
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005971 - ribonucleoside-diphosphate reductase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

638701

RIR1
Ribonucleoside-diphosphate reductase large chain 1

4

9

Small-scale

0.890

High

639563

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

14

High-throughput

0.618

High

639542

MAS5
Mitochondrial protein import protein MAS5

2

3

High-throughput

0.584

High

639561

MPG1
Mannose-1-phosphate guanyltransferase

2

0

High-throughput

0.569

High

522342

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.536

High

549932

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.536

High

639546

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

639544

TF2B
Transcription initiation factor IIB

2

1

High-throughput

0.526

High

639548

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.513

High

639558

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

639567

YNN4
Uncharacterized protein YNL134C

1

0

High-throughput

0.513

High

639571

CCE1
Cruciform cutting endonuclease 1, mitochondrial

1

0

High-throughput

0.513

High

639575

SML1
Ribonucleotide reductase inhibitor protein SML1

1

1

Small-scale

0.508

High

486029

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.500

High

590529

HSP26
Heat shock protein 26

1

2

High-throughput

0.500

High

626583

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

639540

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.500

High

639578

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.500

High

380963

H2B1
Histone H2B.1

1

3

High-throughput

0.489

High

639553

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.486

High

639569

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

High-throughput

0.481

High

386564

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

394238

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.479

High

452811

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.479

High

484720

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.479

High

639550

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.479

High

639556

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.479

High

639568

ACT
Actin

1

0

High-throughput

0.479

High

639570

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

448883

TYSY
Thymidylate synthase

1

1

High-throughput

0.479

High

578845

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

639545

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.479

High

639552

SRX1
Sulfiredoxin

1

0

High-throughput

0.458

High

639562

RFX1
RFX-like DNA-binding protein RFX1

1

0

High-throughput

0.458

High

639564

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.458

High

639565

MTM1
Mitochondrial carrier protein MTM1

1

0

High-throughput

0.458

High

639566

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

639573

HLR1
Protein HLR1

1

0

High-throughput

0.458

High

639577

S2538
Mitochondrial glycine transporter

1

0

High-throughput

0.458

High

639579

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

639560

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

543813

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

639551

LHS1
Heat shock protein 70 homolog LHS1

1

4

High-throughput

0.445

High

639555

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

639543

RFA2
Replication factor A protein 2

1

1

High-throughput

0.437

High

639576

BRE1
E3 ubiquitin-protein ligase BRE1

1

1

High-throughput

0.437

High

639541

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.279

Low

639547

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.279

Low

639572

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.279

Low

405027

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.261

Low

585529

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

639539

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

639549

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.249

Low

639557

MSL1
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.249

Low

639559

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.249

Low

639574

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.249

Low

639554

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025