Protein: ACS2
Acetyl-coenzyme A synthetase 2 (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acyl-activating enzyme 2)

Gene: ACS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P52910

Gene Ontology (top 5):
GO:0003987 - acetate-CoA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

393037

HSP82
ATP-dependent molecular chaperone HSP82

3

5

High-throughput

0.640

High

524567

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.633

High

741978

HSP7F
Heat shock protein homolog SSE1

2

5

High-throughput

0.628

High

545567

SSB1
Ribosome-associated molecular chaperone SSB1

3

4

High-throughput

0.624

High

365118

KPYK1
Pyruvate kinase 1

2

1

Small-scale

0.611

High

531359

METK1
S-adenosylmethionine synthase 1

2

2

Small-scale

0.611

High

621387

METK2
S-adenosylmethionine synthase 2

2

2

Small-scale

0.611

High

626816

HSP60
Heat shock protein 60, mitochondrial

2

6

High-throughput

0.611

High

747476

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.611

High

915265

SMC6
Structural maintenance of chromosomes protein 6

2

1

High-throughput

0.594

High

435228

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.585

High

803622

RPN1
26S proteasome regulatory subunit RPN1

2

0

High-throughput

0.585

High

915247

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.575

High

579742

HSC82
ATP-dependent molecular chaperone HSC82

2

5

High-throughput

0.571

High

915248

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.571

High

594468

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.559

High

826659

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

850102

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

527183

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

819265

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

486255

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.536

High

486492

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.536

High

796161

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.536

High

802881

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.536

High

893315

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.536

High

915243

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

915258

MDN1
Midasin

1

1

High-throughput

0.536

High

368713

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.513

High

394726

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.513

High

597508

EF3A
Elongation factor 3A

1

0

High-throughput

0.513

High

625033

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.513

High

638732

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.513

High

734154

EF2
Elongation factor 2

1

0

High-throughput

0.513

High

915238

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

915242

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

1

High-throughput

0.508

High

655591

TKT1
Transketolase 1

1

0

High-throughput

0.493

High

836061

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.489

High

915245

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.481

High

364647

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

448556

RHO1
GTP-binding protein RHO1

1

12

High-throughput

0.479

High

518337

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

647168

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

670928

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

679878

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

682337

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.479

High

707647

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

727180

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

735066

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

747950

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

808862

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

812083

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

915239

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

High-throughput

0.479

High

915251

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

915252

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

915262

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

915263

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

915264

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

915254

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

3

High-throughput

0.470

High

835836

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.460

High

149861

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383795

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

410234

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

436061

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

455161

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

504315

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

514731

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

674726

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

750734

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

778433

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782171

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

812487

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

828300

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

915236

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

915241

H3
Histone H3

1

0

High-throughput

0.458

High

915244

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

915246

ESP1
Separin

1

0

High-throughput

0.458

High

915255

SGO1
Shugoshin

1

0

High-throughput

0.458

High

915256

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

915259

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

915260

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

359292

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.445

High

453690

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

470560

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

509646

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.445

High

510658

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

597211

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.445

High

692403

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

752509

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

779558

LHS1
Heat shock protein 70 homolog LHS1

1

5

High-throughput

0.445

High

792145

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.445

High

811356

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

915249

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

6

High-throughput

0.445

High

795104

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

915253

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

554027

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.426

High

592371

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

635042

VPS33
Vacuolar protein sorting-associated protein 33

1

0

High-throughput

0.426

High

684783

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

817908

IMB4
Importin subunit beta-4

1

0

High-throughput

0.426

High

671666

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.407

High

915237

COPA
Coatomer subunit alpha

1

5

High-throughput

0.407

High

748188

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.279

Low

836786

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

550675

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.249

Low

558808

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

790215

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

Small-scale

0.249

Low

807829

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

825805

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

915250

SPH1
Protein SPH1

1

0

High-throughput

0.249

Low

915257

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

915240

ZDS2
Protein ZDS2

1

0

High-throughput

0.238

Low

386788

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

427362

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

915261

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025