Protein: SML1
Ribonucleotide reductase inhibitor protein SML1

Gene: SML1
Organism: Saccharomyces cerevisiae S288C
Interactions: 59
UniProt ID: Q04964

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006974 - DNA damage response
GO:0007005 - mitochondrion organization
GO:0008156 - negative regulation of DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

638737

RIR1
Ribonucleoside-diphosphate reductase large chain 1

7

1

Small-scale

0.752

High

809098

DUN1
DNA damage response protein kinase DUN1

7

1

Small-scale

0.751

High

554766

REV1
DNA repair protein REV1

2

0

Small-scale

0.605

High

816402

HSP7E
Heat shock protein SSC3, mitochondrial

2

1

High-throughput

0.601

High

1050110

SML1
Ribonucleotide reductase inhibitor protein SML1

2

0

Small-scale

0.598

High

1041489

MUB1
MYND-type zinc finger protein MUB1

2

0

Small-scale

0.561

High

598916

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.536

High

446248

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.513

High

452686

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.513

High

557633

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

0

High-throughput

0.513

High

673128

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.513

High

818699

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

0

High-throughput

0.513

High

866256

HIR3
Histone transcription regulator 3

1

0

High-throughput

0.513

High

639575

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

Small-scale

0.508

High

666219

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

2

High-throughput

0.501

High

814274

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.501

High

850481

LSB3
LAS seventeen-binding protein 3

1

1

High-throughput

0.501

High

599073

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.500

High

386861

TBB
Tubulin beta chain

1

0

High-throughput

0.493

High

415248

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.493

High

661194

SPT6
Transcription elongation factor SPT6

1

0

High-throughput

0.493

High

746505

BEM3
GTPase-activating protein BEM3

1

0

High-throughput

0.493

High

843233

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.493

High

864448

ZAP1
Zinc-responsive transcriptional regulator ZAP1

1

0

High-throughput

0.493

High

924375

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.493

High

1050112

MDM36
Mitochondrial distribution and morphology protein 36

1

0

High-throughput

0.493

High

1050113

APC9
Anaphase-promoting complex subunit 9

1

0

High-throughput

0.493

High

613514

ADT3
ADP,ATP carrier protein 3

1

1

High-throughput

0.489

High

602635

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

642469

MCK1
Protein kinase MCK1

1

0

High-throughput

0.480

High

597272

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.479

High

709979

BMH1
Protein BMH1

1

0

High-throughput

0.479

High

646535

RAD53
Serine/threonine-protein kinase RAD53

1

0

Small-scale

0.458

High

708169

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

1050114

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

613634

ADT2
ADP,ATP carrier protein 2

1

1

High-throughput

0.457

High

510813

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

525135

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527662

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

546259

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

819783

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

780644

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.438

High

671120

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

538349

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.279

Low

793110

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

617986

IRA1
Inhibitory regulator protein IRA1

1

0

High-throughput

0.269

Low

698123

PEP3
Vacuolar membrane protein PEP3

1

0

High-throughput

0.269

Low

705132

SEC20
Protein transport protein SEC20

1

0

High-throughput

0.269

Low

746249

AIM26
Altered inheritance of mitochondria protein 26, mitochondrial

1

0

High-throughput

0.269

Low

836232

MID1
Stretch-activated cation channel MID1

1

0

High-throughput

0.269

Low

886181

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.269

Low

919605

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.269

Low

1050111

FMP27
Protein FMP27, mitochondrial

1

0

High-throughput

0.269

Low

425150

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

150052

YD396
Putative uncharacterized protein YDR396W

1

0

High-throughput

0.249

Low

918059

YGC4
Putative uncharacterized protein YGL024W

1

0

High-throughput

0.249

Low

548299

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.238

Low

918386

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025