Protein: HELZ
Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein)

Gene: HELZ
Organism: Homo sapiens
Interactions: 81
UniProt ID: P42694

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841035

RACK1
Small ribosomal subunit protein RACK1

4

5

High-throughput

0.860

High

211282

RFOX2
RNA binding protein fox-1 homolog 2

2

12

High-throughput

0.712

High

47959

RBM47
RNA-binding protein 47

1

12

High-throughput

0.575

High

484974

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

10

High-throughput

0.575

High

841037

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.575

High

841038

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

20

High-throughput

0.575

High

841045

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.575

High

841063

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

13

High-throughput

0.575

High

841067

PABP5
Polyadenylate-binding protein 5

1

9

High-throughput

0.575

High

841075

RBM4B
RNA-binding protein 4B

1

17

High-throughput

0.575

High

841076

TCAB1
Telomerase Cajal body protein 1

1

8

High-throughput

0.575

High

841077

LST8
Target of rapamycin complex subunit LST8

1

4

High-throughput

0.575

High

841085

TSAP1
tRNA selenocysteine 1-associated protein 1

1

16

High-throughput

0.575

High

841049

ESRP1
Epithelial splicing regulatory protein 1

2

16

High-throughput

0.552

High

841050

THSD4
Thrombospondin type-1 domain-containing protein 4

2

1

High-throughput

0.552

High

841081

NXF2
Nuclear RNA export factor 2

2

4

High-throughput

0.552

High

841092

KLH20
Kelch-like protein 20

2

1

High-throughput

0.552

High

841095

HCFC2
Host cell factor 2

2

2

High-throughput

0.552

High

841055

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

Small-scale

0.549

High

841032

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

2

0

High-throughput

0.528

High

841065

PIGT
GPI-anchor transamidase component PIGT

2

0

High-throughput

0.528

High

841072

WDR90
WD repeat-containing protein 90

1

4

High-throughput

0.514

High

479048

CEL3A
Chymotrypsin-like elastase family member 3A

2

1

High-throughput

0.504

High

841057

CLASR
CLK4-associating serine/arginine rich protein

2

2

High-throughput

0.504

High

841090

CELA1
Chymotrypsin-like elastase family member 1

2

1

High-throughput

0.504

High

841034

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.457

High

73375

B2CML4
single-stranded DNA cytosine deaminase

1

10

High-throughput

0.445

High

174961

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.445

High

192559

NUP42
Nucleoporin NUP42

1

2

High-throughput

0.445

High

395645

ESR1
Estrogen receptor

1

11

High-throughput

0.445

High

566930

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.445

High

841033

SUMO3
Small ubiquitin-related modifier 3

1

3

Small-scale

0.445

High

841039

IF16
Gamma-interferon-inducible protein 16

1

10

High-throughput

0.445

High

841041

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

2

High-throughput

0.445

High

841046

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.445

High

841048

SWAP1
ATPase SWSAP1

1

1

High-throughput

0.445

High

841051

NBEL2
Neurobeachin-like protein 2

1

7

High-throughput

0.445

High

841064

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.445

High

841066

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.445

High

841069

NEIL1
Endonuclease 8-like 1

1

2

High-throughput

0.445

High

841071

LOXL4
Lysyl oxidase homolog 4

1

2

High-throughput

0.445

High

841073

TCPQM
T-complex protein 1 subunit theta-like 2

1

3

High-throughput

0.445

High

841078

DUS16
Dual specificity protein phosphatase 16

1

3

High-throughput

0.445

High

841080

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.445

High

841082

SHRPN
Sharpin

1

1

High-throughput

0.445

High

841083

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.445

High

841084

LN28A
Protein lin-28 homolog A

1

9

High-throughput

0.445

High

841088

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.445

High

289761

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.426

High

296761

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.426

High

359796

DYR
Dihydrofolate reductase

1

0

High-throughput

0.426

High

841036

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.426

High

841040

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

841042

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.426

High

841043

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.426

High

841044

CBPC6
Cytosolic carboxypeptidase 6

1

0

High-throughput

0.426

High

841058

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

841070

TRM61
tRNA

1

0

High-throughput

0.426

High

841074

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.426

High

841087

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.426

High

841089

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.426

High

841093

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.426

High

841094

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.426

High

229267

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.407

High

644580

TENX
Tenascin-X

1

5

High-throughput

0.407

High

690007

CRBB3
Beta-crystallin B3

1

1

High-throughput

0.407

High

841047

KLH10
Kelch-like protein 10

1

2

High-throughput

0.407

High

841054

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

1

High-throughput

0.407

High

841056

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

3

High-throughput

0.407

High

841060

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

2

High-throughput

0.407

High

841086

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

8

High-throughput

0.407

High

261476

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.232

Low

366397

FA12
Coagulation factor XII

1

0

High-throughput

0.232

Low

841052

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

841053

S2548
Solute carrier family 25 member 48

1

0

High-throughput

0.232

Low

841059

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.232

Low

841061

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

841062

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.232

Low

841068

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.232

Low

841079

CHIA
Acidic mammalian chitinase

1

0

High-throughput

0.232

Low

841091

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025