Protein: T2FB
General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)

Gene: T2FB, GTF2F2
Organism: Homo sapiens
Interactions: 143
UniProt ID: P13984

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005674 - transcription factor TFIIF complex
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

569067

T2FA
General transcription factor IIF subunit 1

10

2

Small-scale

0.973

High

569064

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

2

High-throughput

0.789

High

569094

TF2B
Transcription initiation factor IIB

2

1

Small-scale

0.778

High

569052

TBP
TATA-box-binding protein

1

1

Small-scale

0.647

High

569062

T2EB
Transcription initiation factor IIE subunit beta

1

1

Small-scale

0.647

High

259373

BRD4
Bromodomain-containing protein 4

3

2

High-throughput

0.640

High

569051

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

2

Small-scale

0.639

High

569084

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

1

High-throughput

0.611

High

569061

T2EA
General transcription factor IIE subunit 1

2

1

Small-scale

0.602

High

316345

RMP
Unconventional prefoldin RPB5 interactor 1

2

0

Small-scale

0.585

High

569070

BAG6
Large proline-rich protein BAG6

2

0

High-throughput

0.585

High

569139

ANLN
Anillin

2

0

High-throughput

0.585

High

385413

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.584

High

569078

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

1

Small-scale

0.584

High

569089

H31
Histone H3.1

2

2

High-throughput

0.584

High

569102

FHL2
Four and a half LIM domains protein 2

2

0

High-throughput

0.580

High

569150

MARE3
Microtubule-associated protein RP/EB family member 3

2

0

High-throughput

0.580

High

569141

CBLN4
Cerebellin-4

2

1

High-throughput

0.574

High

395416

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

569055

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

2

Small-scale

0.571

High

371055

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.569

High

340288

YETS4
YEATS domain-containing protein 4

1

2

Small-scale

0.561

High

569071

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.554

High

569050

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.536

High

569079

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.536

High

569082

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.536

High

569048

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

569112

A16L1
Autophagy-related protein 16-1

2

1

High-throughput

0.521

High

569065

OTX2
Homeobox protein OTX2

1

0

High-throughput

0.513

High

569081

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

569088

SUMO1
Small ubiquitin-related modifier 1

1

0

High-throughput

0.513

High

569091

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

569098

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

569099

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

569100

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

569110

LBH
Protein LBH

1

0

High-throughput

0.513

High

569124

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

569134

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

569074

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

370532

FOS
Protein c-Fos

1

1

Small-scale

0.501

High

519704

ANDR
Androgen receptor

1

1

Small-scale

0.501

High

569054

TCEA1
Transcription elongation factor A protein 1

1

3

Small-scale

0.501

High

569057

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

1

Small-scale

0.501

High

569069

AHR
Aryl hydrocarbon receptor

1

1

Small-scale

0.501

High

569119

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.493

High

429225

JUN
Transcription factor Jun

1

0

Small-scale

0.480

High

569049

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

569068

MSX2
Homeobox protein MSX-2

1

0

Small-scale

0.480

High

569101

KLF5
Krueppel-like factor 5

1

0

Small-scale

0.480

High

131706

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

189096

IPO8
Importin-8

1

3

High-throughput

0.479

High

225249

HTSF1
17S U2 SnRNP complex component HTATSF1

1

1

Small-scale

0.479

High

355420

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

569056

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

569072

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

569073

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

569075

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

569076

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

569077

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

569083

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

569092

H33
Histone H3.3

1

2

High-throughput

0.479

High

569095

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

569105

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

569107

TAF5
Transcription initiation factor TFIID subunit 5

1

1

Small-scale

0.479

High

569136

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

569151

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

569154

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.479

High

122587

UBXN8
UBX domain-containing protein 8

1

0

High-throughput

0.458

High

128745

MEN1
Menin

1

0

High-throughput

0.458

High

130693

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.458

High

169920

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

172444

XPO1
Exportin-1

1

0

High-throughput

0.458

High

190803

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

323960

CSTN1
Calsyntenin-1

1

0

High-throughput

0.458

High

421423

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.458

High

557821

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

563109

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

569047

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

569059

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

569060

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

569063

PML
Protein PML

1

0

High-throughput

0.458

High

569066

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

569080

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

569085

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

569086

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

569087

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

569090

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.458

High

569093

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

0

High-throughput

0.458

High

569096

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.458

High

569097

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

569103

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

569104

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

569106

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.458

High

569108

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

Small-scale

0.458

High

569116

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

569117

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

569118

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

569121

RN168
E3 ubiquitin-protein ligase RNF168

1

0

High-throughput

0.458

High

569125

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

569129

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

569133

CRBN
Protein cereblon

1

0

High-throughput

0.458

High

569135

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

569138

ESF1
ESF1 homolog

1

0

High-throughput

0.458

High

569142

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.458

High

569145

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

569146

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

569147

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.458

High

569148

TASOR
Protein TASOR

1

0

High-throughput

0.458

High

569152

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

569144

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

528983

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

569123

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

569113

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

569122

F177A
Protein FAM177A1

2

0

High-throughput

0.318

High

569131

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.316

High

569127

DYT2B
Dynein light chain Tctex-type protein 2B

1

0

High-throughput

0.301

High

482228

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

549526

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

569053

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

569058

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

569109

GAG2E
G antigen 2E

1

0

High-throughput

0.279

Low

569111

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

569128

JPH3
Junctophilin-3

1

0

High-throughput

0.279

Low

569130

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

569143

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

569153

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.279

Low

569155

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

569156

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

569132

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.269

Low

249230

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

0

High-throughput

0.249

Low

293141

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

339415

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.249

Low

390854

TRFE
Serotransferrin

1

0

High-throughput

0.249

Low

411286

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

420333

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

485832

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.249

Low

569114

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

569115

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

569120

SHLD1
Shieldin complex subunit 1

1

0

Small-scale

0.249

Low

569137

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

569140

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.249

Low

569149

VAV3
Guanine nucleotide exchange factor VAV3

1

0

High-throughput

0.249

Low

569126

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025