Protein: ECE1
Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)

Gene: ECE1
Organism: Homo sapiens
Interactions: 100
UniProt ID: P42892

Gene Ontology (top 5):
GO:0001921 - positive regulation of receptor recycling
GO:0003100 - regulation of systemic arterial blood pressure by endothelin
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341292

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.691

High

609616

LEG3
Galectin-3

4

4

Small-scale

0.691

High

698460

CALX
Calnexin

3

4

High-throughput

0.650

High

844197

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

0

High-throughput

0.638

High

127296

LEG8
Galectin-8

2

4

High-throughput

0.628

High

844180

CLK2
Dual specificity protein kinase CLK2

3

1

High-throughput

0.616

High

636486

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

2

0

High-throughput

0.602

High

844217

NPB
Neuropeptide B

2

0

High-throughput

0.602

High

480737

LEG1
Galectin-1

2

4

High-throughput

0.601

High

844195

LRC32
Transforming growth factor beta activator LRRC32

2

1

High-throughput

0.601

High

844191

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.584

High

70135

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

844214

LYPD1
Ly6/PLAUR domain-containing protein 1

2

0

High-throughput

0.576

High

125297

LEG9
Galectin-9

2

4

High-throughput

0.574

High

540345

LAMP1
Lysosome-associated membrane glycoprotein 1

2

1

High-throughput

0.571

High

844187

KR108
Keratin-associated protein 10-8

2

5

High-throughput

0.553

High

844212

KRA13
Keratin-associated protein 1-3

2

5

High-throughput

0.553

High

170692

CLGN
Calmegin

2

4

High-throughput

0.549

High

409563

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

10

High-throughput

0.536

High

567811

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.536

High

607351

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

4

High-throughput

0.536

High

627508

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

9

High-throughput

0.536

High

705949

CD1B
T-cell surface glycoprotein CD1b

1

9

High-throughput

0.536

High

731824

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.536

High

844194

PTC1
Protein patched homolog 1

1

1

High-throughput

0.536

High

844200

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.536

High

844221

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.536

High

844223

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

844232

FBX6
F-box only protein 6

2

2

High-throughput

0.533

High

188830

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.515

High

168387

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.513

High

561350

TDGF1
Protein Cripto

1

0

High-throughput

0.513

High

593305

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

844199

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

844207

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

844211

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

844222

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

844227

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.513

High

844230

UD17
UDP-glucuronosyltransferase 1A7

1

0

High-throughput

0.513

High

844231

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

844240

PCDA9
Protocadherin alpha-9

1

0

High-throughput

0.513

High

844241

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

0

High-throughput

0.513

High

844178

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.508

High

369540

ANGT
Angiotensinogen

1

2

Small-scale

0.501

High

370403

KNG1
Kininogen-1

1

3

Small-scale

0.501

High

416599

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.489

High

844228

CST11
Cystatin-11

1

3

High-throughput

0.489

High

844236

FBX2
F-box only protein 2

1

2

High-throughput

0.489

High

217929

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

373819

RASN
GTPase NRas

1

4

High-throughput

0.479

High

630713

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.479

High

631102

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

844181

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.479

High

844182

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

844183

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

844184

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.479

High

844189

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.479

High

844198

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

844206

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

844209

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

844210

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.479

High

844218

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

844233

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

844234

T106B
Transmembrane protein 106B

1

2

High-throughput

0.479

High

844237

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

844238

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.479

High

844186

KR105
Keratin-associated protein 10-5

1

5

High-throughput

0.470

High

844225

MYOC
Myocilin

1

0

Small-scale

0.460

High

189446

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

844188

RAC3
Ras-related C3 botulinum toxin substrate 3

1

0

High-throughput

0.458

High

844190

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

844192

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

844235

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

844242

PCLO
Protein piccolo

1

0

High-throughput

0.458

High

844179

CLK1
Dual specificity protein kinase CLK1

1

1

High-throughput

0.457

High

437638

HEPS
Serine protease hepsin

1

4

High-throughput

0.445

High

844177

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.445

High

844193

VMAT2
Synaptic vesicular amine transporter

1

4

High-throughput

0.445

High

844216

SPX3
Sugar phosphate exchanger 3

1

4

High-throughput

0.445

High

844185

KR101
Keratin-associated protein 10-1

1

5

High-throughput

0.439

High

48226

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.426

High

399435

TRGV3
T cell receptor gamma variable 3

1

0

High-throughput

0.426

High

844215

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.426

High

844204

SUSD4
Sushi domain-containing protein 4

2

0

High-throughput

0.328

High

844220

PATE1
Prostate and testis expressed protein 1

2

0

High-throughput

0.313

High

191434

SIA8E
Alpha-2,8-sialyltransferase 8E

1

0

High-throughput

0.279

Low

547983

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

844196

EP3A
Epididymal secretory protein E3-alpha

1

0

High-throughput

0.279

Low

844208

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.279

Low

844224

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

844229

CG069
Putative uncharacterized protein PKD1L1-AS1

1

0

High-throughput

0.279

Low

449645

CALCA
Calcitonin gene-related peptide 1

1

0

Small-scale

0.261

Low

844202

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.249

Low

844203

MIDN
Midnolin

1

0

High-throughput

0.249

Low

844205

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

844213

GPAM1
GPALPP motifs-containing protein 1

1

0

High-throughput

0.249

Low

844219

DOK4
Docking protein 4

1

0

High-throughput

0.249

Low

844226

THUM2
U6 snRNA

1

0

High-throughput

0.249

Low

844239

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

844201

DB109
Beta-defensin 109B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025