Protein: CLN6
Ceroid-lipofuscinosis neuronal protein 6 (Protein CLN6)

Gene: CLN6
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q9NWW5

Gene Ontology (top 5):
GO:0001573 - ganglioside metabolic process
GO:0005730 - nucleolus
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549900

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

850857

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

0

High-throughput

0.580

High

1214425

GORAB
RAB6-interacting golgin

2

0

High-throughput

0.580

High

1279094

RIC3
Protein RIC-3

2

0

High-throughput

0.580

High

1281203

CPLX4
Complexin-4

2

0

High-throughput

0.580

High

1308351

TM139
Transmembrane protein 139

2

0

High-throughput

0.580

High

1324876

LRC25
Leucine-rich repeat-containing protein 25

2

0

High-throughput

0.580

High

1327981

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1348796

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.580

High

1384368

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

1400562

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

1410441

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.580

High

1451547

TX264
Testis-expressed protein 264

2

0

High-throughput

0.580

High

1408204

RNF5
E3 ubiquitin-protein ligase RNF5

2

1

Small-scale

0.571

High

189011

TMPS2
Transmembrane protease serine 2

2

2

High-throughput

0.553

High

182805

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.513

High

519672

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.513

High

783672

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.513

High

873375

AL3B2
Aldehyde dehydrogenase family 3 member B2

1

0

High-throughput

0.513

High

1104514

ILK
Scaffold protein ILK

1

0

High-throughput

0.513

High

1244910

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

1325935

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1350088

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1363240

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1434653

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1451544

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.513

High

412699

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.500

High

1055103

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

1

High-throughput

0.500

High

132344

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.493

High

1432881

TMPS5
Transmembrane protease serine 5

1

2

High-throughput

0.489

High

487815

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

1045836

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1211675

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

1

High-throughput

0.479

High

1287455

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

High-throughput

0.479

High

1448836

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

1451541

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

High-throughput

0.479

High

163597

TPP1
Tripeptidyl-peptidase 1

1

0

Small-scale

0.458

High

218849

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

284420

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

384737

CRYAB
Alpha-crystallin B chain

1

0

Small-scale

0.458

High

538004

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

800131

COIL
Coilin

1

0

High-throughput

0.458

High

898535

PPT1
Palmitoyl-protein thioesterase 1

1

0

Small-scale

0.458

High

935192

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

980436

H4
Histone H4

1

0

High-throughput

0.458

High

1125695

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1163816

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

1252255

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1276336

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1334999

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1383115

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1406328

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

1414476

DERL1
Derlin-1

1

0

Small-scale

0.458

High

1157088

NTRK3
NT-3 growth factor receptor

1

1

High-throughput

0.457

High

173451

XPO1
Exportin-1

1

1

Small-scale

0.445

High

283375

ERLN1
Erlin-1

1

1

Small-scale

0.445

High

321368

ERLN2
Erlin-2

1

1

Small-scale

0.445

High

839387

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.445

High

944083

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1365777

GCN1
Stalled ribosome sensor GCN1

1

1

Small-scale

0.445

High

626376

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.437

High

765936

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.437

High

1404796

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.437

High

1433452

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1451538

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.437

High

1451539

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.437

High

165664

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.426

High

254308

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

0

Small-scale

0.426

High

276982

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

Small-scale

0.426

High

325614

YIF1A
Protein YIF1A

1

0

Small-scale

0.426

High

380168

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

598219

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

Small-scale

0.426

High

753848

MRP1
Multidrug resistance-associated protein 1

1

0

Small-scale

0.426

High

813237

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.426

High

863570

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

Small-scale

0.426

High

869684

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.426

High

925617

MOT1
Monocarboxylate transporter 1

1

0

Small-scale

0.426

High

1031873

LAT1
Large neutral amino acids transporter small subunit 1

1

0

Small-scale

0.426

High

1326923

EMC5
ER membrane protein complex subunit 5

1

0

Small-scale

0.426

High

1348073

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

Small-scale

0.426

High

1406241

CHP1
Calcineurin B homologous protein 1

1

0

Small-scale

0.426

High

1439661

TM9S3
Transmembrane 9 superfamily member 3

1

0

Small-scale

0.426

High

1451535

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

1451536

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

Small-scale

0.426

High

1451543

TELO2
Telomere length regulation protein TEL2 homolog

1

0

Small-scale

0.426

High

1451546

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.426

High

1451540

XPO7
Exportin-7

1

1

Small-scale

0.407

High

50127

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.316

High

140008

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

2

0

High-throughput

0.316

High

166430

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

0

High-throughput

0.316

High

337915

CLD7
Claudin-7

2

0

High-throughput

0.316

High

761170

EVI2B
Protein EVI2B

2

0

High-throughput

0.316

High

870802

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

1159646

STX1A
Syntaxin-1A

2

0

High-throughput

0.316

High

1187582

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

1207641

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

1307737

CLC10
C-type lectin domain family 10 member A

2

0

High-throughput

0.316

High

1433035

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

1327800

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

166061

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

351976

S1PR4
Sphingosine 1-phosphate receptor 4

1

0

High-throughput

0.279

Low

733090

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

749409

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

1248403

I27RA
Interleukin-27 receptor subunit alpha

1

0

High-throughput

0.279

Low

1309556

NNRD
ATP-dependent

1

0

High-throughput

0.279

Low

1310467

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1350905

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1399631

OPALI
Opalin

1

0

High-throughput

0.279

Low

1432121

KLK15
Kallikrein-15

1

0

High-throughput

0.279

Low

1451542

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.279

Low

1451545

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

710903

EPHB2
Ephrin type-B receptor 2

1

0

High-throughput

0.268

Low

386296

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

294418

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

589854

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696673

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769339

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831526

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879531

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

883713

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.249

Low

971178

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1164088

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.249

Low

1276868

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1398293

KCTD7
BTB/POZ domain-containing protein KCTD7

1

0

Small-scale

0.249

Low

1433538

RHOJ
Rho-related GTP-binding protein RhoJ

1

0

High-throughput

0.249

Low

1435360

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1415973

IFT27
Intraflagellar transport protein 27 homolog

1

0

High-throughput

0.232

Low

1451537

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025