Protein: SF3B5
Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)

Gene: SF3B5
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9BWJ5

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1148031

SF3B3
Splicing factor 3B subunit 3

6

1

Small-scale

0.935

High

1274046

PHF5A
PHD finger-like domain-containing protein 5A

3

1

High-throughput

0.861

High

1105399

SF3B2
Splicing factor 3B subunit 2

2

1

High-throughput

0.789

High

485722

RU2A
U2 small nuclear ribonucleoprotein A'

5

1

High-throughput

0.718

High

286054

SF3B1
Splicing factor 3B subunit 1

5

1

Small-scale

0.709

High

1148649

SF3A2
Splicing factor 3A subunit 2

4

1

Small-scale

0.686

High

1390379

CCD97
Coiled-coil domain-containing protein 97

3

1

High-throughput

0.675

High

1416257

SF3B6
Splicing factor 3B subunit 6

3

3

Small-scale

0.660

High

1287322

TAD2B
Transcriptional adapter 2-beta

3

1

High-throughput

0.656

High

471914

RU2B
U2 small nuclear ribonucleoprotein B''

2

2

High-throughput

0.628

High

574455

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

2

High-throughput

0.628

High

973812

RUXE
Small nuclear ribonucleoprotein E

2

1

High-throughput

0.628

High

974036

RUXF
Small nuclear ribonucleoprotein F

2

2

High-throughput

0.628

High

283622

SUPT3
Transcription initiation protein SPT3 homolog

2

1

High-throughput

0.611

High

284873

TADA3
Transcriptional adapter 3

2

1

High-throughput

0.611

High

1088739

SF3A3
Splicing factor 3A subunit 3

2

1

High-throughput

0.611

High

1149178

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.611

High

1369158

KAT2A
Histone acetyltransferase KAT2A

2

2

High-throughput

0.611

High

1384786

TADA1
Transcriptional adapter 1

2

1

High-throughput

0.611

High

1389685

SGF29
SAGA-associated factor 29

2

1

High-throughput

0.611

High

1416253

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

0

High-throughput

0.608

High

1157608

TAF12
Transcription initiation factor TFIID subunit 12

2

1

High-throughput

0.601

High

1337581

SP20H
Transcription factor SPT20 homolog

2

0

High-throughput

0.585

High

396859

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1034057

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.547

High

284980

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

2

High-throughput

0.536

High

854270

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

952020

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

1

High-throughput

0.536

High

974192

RUXG
Small nuclear ribonucleoprotein G

1

6

High-throughput

0.536

High

974463

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.536

High

974656

SMD2
Small nuclear ribonucleoprotein Sm D2

1

1

High-throughput

0.536

High

991240

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

3

High-throughput

0.536

High

1127132

RBM39
RNA-binding protein 39

1

2

High-throughput

0.536

High

1148556

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.536

High

1159332

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.536

High

1294112

DDX42
ATP-dependent RNA helicase DDX42

1

1

High-throughput

0.536

High

1369204

KAT2B
Histone acetyltransferase KAT2B

1

2

High-throughput

0.536

High

1416246

NADAP
Kanadaptin

1

1

High-throughput

0.536

High

1416248

SKI8
Superkiller complex protein 8

1

2

High-throughput

0.536

High

1416250

TAF9B
Transcription initiation factor TFIID subunit 9B

1

2

High-throughput

0.536

High

1416258

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.536

High

1295390

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

1

High-throughput

0.521

High

298443

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.513

High

319170

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

476799

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.513

High

586867

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.513

High

769074

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.513

High

876984

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.513

High

909172

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

1231222

KDM4D
Lysine-specific demethylase 4D

1

0

High-throughput

0.513

High

1234617

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1290696

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.513

High

1328477

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

High-throughput

0.513

High

1402987

IWS1
Protein IWS1 homolog

1

0

High-throughput

0.513

High

1416255

SRPK3
SRSF protein kinase 3

1

0

High-throughput

0.513

High

1416259

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.513

High

685713

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

Small-scale

0.501

High

508551

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

326014

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

Small-scale

0.479

High

373044

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406590

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

786818

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

971024

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1135639

AT7L3
Ataxin-7-like protein 3

1

1

High-throughput

0.479

High

1287010

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1313397

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1346915

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

129391

MEN1
Menin

1

0

High-throughput

0.458

High

132279

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

320033

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349228

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

401420

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

473042

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

607069

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

851657

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

879431

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

905100

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

980263

H4
Histone H4

1

0

High-throughput

0.458

High

998762

H31
Histone H3.1

1

0

High-throughput

0.458

High

1092224

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1138592

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1194351

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1271836

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1276736

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1368369

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1380134

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1416247

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

1416251

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1416252

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.458

High

1416254

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1416256

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

324311

ARHGF
Rho guanine nucleotide exchange factor 15

1

3

High-throughput

0.437

High

584581

VAV
Proto-oncogene vav

1

2

High-throughput

0.437

High

1023028

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

2

High-throughput

0.437

High

1227384

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1328556

NGEF
Ephexin-1

1

3

High-throughput

0.437

High

207640

DHX15
ATP-dependent RNA helicase DHX15

1

0

High-throughput

0.426

High

344307

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1150810

SF01
Splicing factor 1

1

0

High-throughput

0.426

High

1203247

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

1209611

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1292285

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1244716

TTC33
Tetratricopeptide repeat protein 33

2

0

High-throughput

0.318

High

296001

TPC6A
Trafficking protein particle complex subunit 6A

2

0

High-throughput

0.316

High

1390675

STALP
AMSH-like protease

2

0

High-throughput

0.316

High

276168

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

1213437

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.279

Low

1331524

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

294282

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

318871

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

995799

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1178685

RHG31
Rho GTPase-activating protein 31

1

0

High-throughput

0.249

Low

1252963

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1327173

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1416249

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

62590

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

87534

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

133574

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

1335705

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025