Protein: MED18
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)

Gene: MED18
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9BUE0

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1414141

MED20
Mediator of RNA polymerase II transcription subunit 20

12

2

Small-scale

0.985

High

1414146

MED17
Mediator of RNA polymerase II transcription subunit 17

8

1

Small-scale

0.969

High

1149708

MED22
Mediator of RNA polymerase II transcription subunit 22

6

1

Small-scale

0.950

High

1391333

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

High-throughput

0.932

High

1414150

MED11
Mediator of RNA polymerase II transcription subunit 11

4

1

High-throughput

0.909

High

667430

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.827

High

1413626

MED10
Mediator of RNA polymerase II transcription subunit 10

10

1

Small-scale

0.759

High

49009

MED19
Mediator of RNA polymerase II transcription subunit 19

10

1

Small-scale

0.758

High

1414148

MED29
Mediator of RNA polymerase II transcription subunit 29

9

1

Small-scale

0.756

High

1414145

MED4
Mediator of RNA polymerase II transcription subunit 4

8

1

Small-scale

0.752

High

1372188

MED12
Mediator of RNA polymerase II transcription subunit 12

7

2

Small-scale

0.751

High

881596

CDK8
Cyclin-dependent kinase 8

7

3

High-throughput

0.750

High

1414151

MED13
Mediator of RNA polymerase II transcription subunit 13

6

2

Small-scale

0.736

High

666900

CCNC
Cyclin-C

6

1

High-throughput

0.729

High

219512

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

239613

MED14
Mediator of RNA polymerase II transcription subunit 14

5

2

High-throughput

0.722

High

1241410

MED27
Mediator of RNA polymerase II transcription subunit 27

5

1

High-throughput

0.722

High

1393375

MED30
Mediator of RNA polymerase II transcription subunit 30

5

1

High-throughput

0.722

High

1414155

MED31
Mediator of RNA polymerase II transcription subunit 31

5

1

High-throughput

0.722

High

1414147

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.720

High

282415

MED24
Mediator of RNA polymerase II transcription subunit 24

5

1

High-throughput

0.718

High

287815

MED6
Mediator of RNA polymerase II transcription subunit 6

5

2

Small-scale

0.718

High

1414153

MED23
Mediator of RNA polymerase II transcription subunit 23

5

1

High-throughput

0.718

High

1414154

MED16
Mediator of RNA polymerase II transcription subunit 16

5

1

High-throughput

0.718

High

1108391

MED21
Mediator of RNA polymerase II transcription subunit 21

7

0

Small-scale

0.716

High

1151291

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.709

High

336027

MED26
Mediator of RNA polymerase II transcription subunit 26

6

0

High-throughput

0.707

High

1414140

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

High-throughput

0.705

High

1401564

MED15
Mediator of RNA polymerase II transcription subunit 15

4

1

High-throughput

0.694

High

1414139

CDK19
Cyclin-dependent kinase 19

4

3

High-throughput

0.694

High

1259067

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.675

High

1414144

TRI39
E3 ubiquitin-protein ligase TRIM39

4

0

High-throughput

0.670

High

1295673

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

2

High-throughput

0.667

High

1311773

HOMEZ
Homeobox and leucine zipper protein Homez

3

0

High-throughput

0.639

High

1259276

MED25
Mediator of RNA polymerase II transcription subunit 25

2

1

High-throughput

0.611

High

188714

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

621733

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.602

High

621953

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

976142

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.602

High

1313040

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.602

High

1414138

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.586

High

1224726

KFA
Kynurenine formamidase

2

0

High-throughput

0.580

High

1112450

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

2

1

High-throughput

0.574

High

1414149

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

2

1

High-throughput

0.574

High

1110294

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

0

High-throughput

0.549

High

1110040

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.536

High

1368093

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.536

High

723071

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

787780

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

900131

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.513

High

912115

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

912222

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.513

High

1414142

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.513

High

283542

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

520342

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

1367158

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

260391

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

401406

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

589566

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

1089003

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1115971

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

1257816

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1346911

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.458

High

1407408

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1401861

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

76436

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

95756

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

542807

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

0

High-throughput

0.328

High

1398695

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

1200328

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

1214769

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.279

Low

1278213

CLAP1
CLIP-associating protein 1

1

0

High-throughput

0.279

Low

1359536

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1400110

CMA1A
Ciliary microtubule associated protein 1A

1

0

High-throughput

0.279

Low

1411236

REEP2
Receptor expression-enhancing protein 2

1

0

High-throughput

0.279

Low

1414143

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.279

Low

1414152

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

942851

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025