Protein: MED19
Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19)

Gene: MED19
Organism: Homo sapiens
Interactions: 181
UniProt ID: A0JLT2

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

49008

MED10
Mediator of RNA polymerase II transcription subunit 10

11

1

Small-scale

0.980

High

48878

MED7
Mediator of RNA polymerase II transcription subunit 7

9

1

Small-scale

0.975

High

48879

MED14
Mediator of RNA polymerase II transcription subunit 14

8

2

Small-scale

0.970

High

49045

MED31
Mediator of RNA polymerase II transcription subunit 31

10

2

Small-scale

0.760

High

49020

MED4
Mediator of RNA polymerase II transcription subunit 4

11

1

Small-scale

0.759

High

48923

CDK8
Cyclin-dependent kinase 8

11

3

Small-scale

0.758

High

49024

MED17
Mediator of RNA polymerase II transcription subunit 17

10

1

Small-scale

0.758

High

48961

MED1
Mediator of RNA polymerase II transcription subunit 1

11

1

Small-scale

0.758

High

49001

MED8
Mediator of RNA polymerase II transcription subunit 8

10

2

Small-scale

0.758

High

49009

MED18
Mediator of RNA polymerase II transcription subunit 18

10

1

Small-scale

0.758

High

49027

MED11
Mediator of RNA polymerase II transcription subunit 11

9

1

Small-scale

0.757

High

49032

MED13
Mediator of RNA polymerase II transcription subunit 13

10

2

Small-scale

0.756

High

48976

MED27
Mediator of RNA polymerase II transcription subunit 27

9

1

Small-scale

0.754

High

48996

MED12
Mediator of RNA polymerase II transcription subunit 12

9

2

Small-scale

0.754

High

49011

CDK19
Cyclin-dependent kinase 19

9

3

Small-scale

0.753

High

49002

MED30
Mediator of RNA polymerase II transcription subunit 30

8

1

Small-scale

0.752

High

49038

MED23
Mediator of RNA polymerase II transcription subunit 23

8

1

Small-scale

0.752

High

48979

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

7

2

High-throughput

0.750

High

48980

MED25
Mediator of RNA polymerase II transcription subunit 25

8

1

Small-scale

0.750

High

49004

MED15
Mediator of RNA polymerase II transcription subunit 15

7

1

High-throughput

0.750

High

48906

CCNC
Cyclin-C

8

1

Small-scale

0.749

High

48881

MED24
Mediator of RNA polymerase II transcription subunit 24

7

1

Small-scale

0.747

High

49026

MED29
Mediator of RNA polymerase II transcription subunit 29

10

0

Small-scale

0.726

High

48882

MED6
Mediator of RNA polymerase II transcription subunit 6

10

0

Small-scale

0.725

High

49018

MED20
Mediator of RNA polymerase II transcription subunit 20

9

0

Small-scale

0.724

High

48949

MED21
Mediator of RNA polymerase II transcription subunit 21

9

0

Small-scale

0.722

High

48887

MED26
Mediator of RNA polymerase II transcription subunit 26

10

0

Small-scale

0.722

High

49013

MED28
Mediator of RNA polymerase II transcription subunit 28

9

0

Small-scale

0.722

High

49025

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.722

High

49042

MED16
Mediator of RNA polymerase II transcription subunit 16

8

0

Small-scale

0.720

High

48985

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

5

2

High-throughput

0.718

High

48907

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

0

High-throughput

0.718

High

48960

MED22
Mediator of RNA polymerase II transcription subunit 22

8

0

Small-scale

0.717

High

48877

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

High-throughput

0.674

High

48904

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

0

High-throughput

0.674

High

48903

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

High-throughput

0.670

High

48913

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

0

High-throughput

0.670

High

48867

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

Small-scale

0.667

High

48917

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

0

High-throughput

0.638

High

48929

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

0

High-throughput

0.638

High

48930

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.638

High

48933

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.638

High

48936

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

0

High-throughput

0.638

High

48937

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

0

High-throughput

0.638

High

48931

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

0

High-throughput

0.628

High

48986

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.606

High

48977

FXL19
F-box/LRR-repeat protein 19

2

0

High-throughput

0.602

High

48871

ELL2
RNA polymerase II elongation factor ELL2

2

1

High-throughput

0.601

High

48880

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

48916

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

48938

GRB2
Growth factor receptor-bound protein 2

2

0

High-throughput

0.580

High

48943

RIPP1
Protein ripply1

2

0

High-throughput

0.580

High

48953

CASL
Enhancer of filamentation 1

2

0

High-throughput

0.580

High

48984

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

48892

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

49030

AFF4
AF4/FMR2 family member 4

2

1

High-throughput

0.571

High

48945

TADBP
TAR DNA-binding protein 43

2

0

High-throughput

0.563

High

48884

UBR5
E3 ubiquitin-protein ligase UBR5

2

0

High-throughput

0.547

High

48912

MSX1
Homeobox protein MSX-1

1

2

High-throughput

0.541

High

48909

IKBA
NF-kappa-B inhibitor alpha

1

0

High-throughput

0.518

High

48911

DCK
Deoxycytidine kinase

1

0

High-throughput

0.518

High

48870

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.513

High

48920

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

48941

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

48942

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

48946

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

48962

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.513

High

48966

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.513

High

48975

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

48983

TAD2B
Transcriptional adapter 2-beta

1

0

High-throughput

0.513

High

48998

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

49000

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.513

High

49019

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.513

High

49046

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

48901

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.493

High

48934

1433G
14-3-3 protein gamma

1

0

High-throughput

0.493

High

48956

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.493

High

48988

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

48995

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

48894

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

48900

GATA1
Erythroid transcription factor

1

0

Small-scale

0.479

High

48874

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

48896

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

48908

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.479

High

48944

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

48957

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

48963

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

48964

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

48969

BRDT
Bromodomain testis-specific protein

1

3

High-throughput

0.479

High

48987

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

48885

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

48888

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

48893

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

48897

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

48922

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

48970

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

48971

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

48978

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

48997

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

49015

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

49017

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

49021

ANLN
Anillin

1

0

High-throughput

0.458

High

49029

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

48872

NOP56
Nucleolar protein 56

1

1

High-throughput

0.445

High

48948

TCOF
Treacle protein

1

1

High-throughput

0.445

High

48950

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.445

High

48951

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.445

High

48954

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

High-throughput

0.445

High

48991

ELYS
Protein ELYS

1

1

High-throughput

0.445

High

49016

DDX31
ATP-dependent DNA helicase DDX31

1

1

High-throughput

0.445

High

49022

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.445

High

49031

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.445

High

49037

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.445

High

49041

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.445

High

49043

NOP58
Nucleolar protein 58

1

1

High-throughput

0.445

High

48994

OSTF1
Osteoclast-stimulating factor 1

1

1

High-throughput

0.439

High

49003

RADIL
Ras-associating and dilute domain-containing protein

1

1

High-throughput

0.439

High

49039

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

48873

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.426

High

48875

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.426

High

48876

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.426

High

48886

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.426

High

48890

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.426

High

48895

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

48902

UBF1
Nucleolar transcription factor 1

1

0

High-throughput

0.426

High

48905

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.426

High

48910

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.426

High

48914

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.426

High

48915

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

48919

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

0

High-throughput

0.426

High

48921

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.426

High

48926

HCFC1
Host cell factor 1

1

0

High-throughput

0.426

High

48927

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.426

High

48928

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.426

High

48932

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.426

High

48935

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.426

High

48939

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.426

High

48940

SRSF3
Serine/arginine-rich splicing factor 3

1

0

High-throughput

0.426

High

48947

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

0

High-throughput

0.426

High

48952

RBM39
RNA-binding protein 39

1

0

High-throughput

0.426

High

48955

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.426

High

48958

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.426

High

48959

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.426

High

48965

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.426

High

48967

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

48968

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.426

High

48990

IPO4
Importin-4

1

0

High-throughput

0.426

High

48999

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.426

High

49007

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.426

High

49010

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.426

High

49012

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.426

High

49014

PININ
Pinin

1

0

High-throughput

0.426

High

49023

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.426

High

49028

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.426

High

49034

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.426

High

49035

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

49036

ANC2
Anaphase-promoting complex subunit 2

1

0

High-throughput

0.426

High

49040

RUVB1
RuvB-like 1

1

0

High-throughput

0.426

High

49044

ZN281
Zinc finger protein 281

1

0

High-throughput

0.426

High

48981

Q75LH2
Ras-associating and dilute domain-containing protein

1

1

High-throughput

0.417

High

48868

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

48869

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

48883

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.407

High

48918

HSPA9
Stress-70 protein, mitochondrial

1

1

High-throughput

0.407

High

49005

DDX50
ATP-dependent RNA helicase DDX50

1

2

High-throughput

0.407

High

48925

BPL1
Biotin--protein ligase

2

0

High-throughput

0.316

High

48972

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.316

High

49033

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

48891

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

48973

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

48974

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

0

High-throughput

0.238

Low

48889

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.232

Low

48898

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

48899

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.232

Low

48924

DYN2
Dynamin-2

1

0

High-throughput

0.232

Low

48982

NOL8
Nucleolar protein 8

1

0

High-throughput

0.232

Low

48989

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.232

Low

48992

TITIN
Titin

1

0

High-throughput

0.232

Low

48993

GCN1
Stalled ribosome sensor GCN1

1

0

High-throughput

0.232

Low

49006

CMS1
Protein CMSS1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025