Protein: PPGB
Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

Gene: PPGB, CTSA
Organism: Homo sapiens
Interactions: 94
UniProt ID: P10619

Gene Ontology (top 5):
GO:0004180 - carboxypeptidase activity
GO:0004185 - serine-type carboxypeptidase activity
GO:0005576 - extracellular region
GO:0005764 - lysosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528671

RHOA
Transforming protein RhoA

5

1

High-throughput

0.709

High

528659

BGAL
Beta-galactosidase

2

0

High-throughput

0.699

High

528721

FBX6
F-box only protein 6

4

1

High-throughput

0.683

High

528662

DNJB2
DnaJ homolog subfamily B member 2

4

2

High-throughput

0.630

High

466081

RHOC
Rho-related GTP-binding protein RhoC

2

1

High-throughput

0.628

High

528727

FZR1
Fizzy-related protein homolog

2

1

High-throughput

0.549

High

395378

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

528661

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.536

High

528712

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

528660

CDK2
Cyclin-dependent kinase 2

2

1

High-throughput

0.521

High

528718

LT4R2
Leukotriene B4 receptor 2

1

0

High-throughput

0.518

High

474430

VIME
Vimentin

1

0

High-throughput

0.513

High

528672

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.513

High

528723

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

528726

TAOK2
Serine/threonine-protein kinase TAO2

1

3

High-throughput

0.489

High

166850

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.481

High

274966

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.481

High

328805

CSPG5
Chondroitin sulfate proteoglycan 5

1

1

High-throughput

0.481

High

385393

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.481

High

528657

MUC1
Mucin-1

1

1

High-throughput

0.481

High

528658

LEUK
Leukosialin

1

1

High-throughput

0.481

High

528664

STX2
Syntaxin-2

1

1

High-throughput

0.481

High

528665

AQP2
Aquaporin-2

1

3

High-throughput

0.481

High

528673

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.481

High

528681

NACHO
Novel acetylcholine receptor chaperone

1

1

High-throughput

0.481

High

528682

F209A
Protein FAM209A

1

1

High-throughput

0.481

High

528684

MF14B
Hippocampus abundant transcript-like protein 1

1

7

High-throughput

0.481

High

528686

TM154
Transmembrane protein 154

1

1

High-throughput

0.481

High

528690

TM139
Transmembrane protein 139

1

1

High-throughput

0.481

High

528698

FNDC9
Fibronectin type III domain-containing protein 9

1

1

High-throughput

0.481

High

528700

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.481

High

528701

SSMM1
Serine-rich single-pass membrane protein 1

1

1

High-throughput

0.481

High

528705

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

1

High-throughput

0.481

High

528709

TM237
Transmembrane protein 237

1

1

High-throughput

0.481

High

528711

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

2

High-throughput

0.481

High

528715

REEP4
Receptor expression-enhancing protein 4

1

2

High-throughput

0.481

High

528717

RN122
RING finger protein 122

1

1

High-throughput

0.481

High

528720

SAR1A
Small COPII coat GTPase SAR1A

1

4

High-throughput

0.481

High

528729

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.481

High

528731

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.481

High

528655

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.479

High

528666

HD
Huntingtin

1

1

High-throughput

0.479

High

528670

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

528704

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

528707

NECT4
Nectin-4

1

1

High-throughput

0.479

High

528710

NEUR1
Sialidase-1

1

1

Small-scale

0.479

High

528725

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

528722

CNBP1
Beta-catenin-interacting protein 1

1

1

High-throughput

0.470

High

528683

TMM31
Transmembrane protein 31

1

0

High-throughput

0.460

High

179128

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

0

Small-scale

0.458

High

226686

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

Small-scale

0.458

High

347491

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

528654

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

528678

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

528693

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

528695

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

528714

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

327756

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.445

High

528713

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

528724

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.445

High

528656

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

High-throughput

0.439

High

528663

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.439

High

528668

VMAT1
Chromaffin granule amine transporter

1

2

High-throughput

0.439

High

528675

AQP6
Aquaporin-6

1

3

High-throughput

0.439

High

528680

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.439

High

528685

GORAB
RAB6-interacting golgin

1

1

High-throughput

0.439

High

528689

CPLX4
Complexin-4

1

1

High-throughput

0.439

High

528691

AHNK2
Protein AHNAK2

1

1

High-throughput

0.439

High

528697

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

1

High-throughput

0.439

High

528702

THAP4
Peroxynitrite isomerase THAP4

1

1

High-throughput

0.439

High

528703

BSND
Barttin

1

1

High-throughput

0.439

High

528708

SIG12
Sialic acid-binding Ig-like lectin 12

1

2

High-throughput

0.439

High

528730

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.439

High

217753

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

330608

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

400184

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

528687

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

528706

CALR3
Calreticulin-3

1

4

High-throughput

0.437

High

528716

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

528669

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

High-throughput

0.407

High

528699

SFXN5
Sideroflexin-5

3

0

High-throughput

0.345

High

528696

KLDC9
Kelch domain-containing protein 9

2

0

High-throughput

0.328

High

528676

LAGE3
EKC/KEOPS complex subunit LAGE3

2

0

High-throughput

0.313

High

528677

MD2BP
MAD2L1-binding protein

2

0

High-throughput

0.313

High

528692

CI040
Uncharacterized protein C9orf40

2

0

High-throughput

0.313

High

528728

PHF8
Histone lysine demethylase PHF8

2

0

High-throughput

0.313

High

528688

MEPCE
7SK snRNA methylphosphate capping enzyme

2

0

High-throughput

0.305

High

528667

RORG
Nuclear receptor ROR-gamma

1

0

High-throughput

0.279

Low

528694

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

High-throughput

0.279

Low

528679

SOAT
Sodium-dependent organic anion transporter

1

0

High-throughput

0.251

Low

247628

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

293106

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

528719

ANLN
Anillin

1

0

High-throughput

0.249

Low

528674

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025