Protein: AMD
Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]

Gene: AMD, PAM
Organism: Homo sapiens
Interactions: 52
UniProt ID: P19021

Gene Ontology (top 5):
GO:0001519 - peptide amidation
GO:0004504 - peptidylglycine monooxygenase activity
GO:0004598 - peptidylamidoglycolate lyase activity
GO:0005507 - copper ion binding
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

618195

TMM25
Transmembrane protein 25

3

1

High-throughput

0.667

High

618196

UBR2
E3 ubiquitin-protein ligase UBR2

4

0

High-throughput

0.661

High

618187

NAR3
Ecto-ADP-ribosyltransferase 3

3

1

High-throughput

0.656

High

467313

CBG
Corticosteroid-binding globulin

3

0

High-throughput

0.638

High

618176

IDS
Iduronate 2-sulfatase

2

1

High-throughput

0.611

High

618188

PTC1
Protein patched homolog 1

3

1

High-throughput

0.609

High

618189

TAZ
Tafazzin

3

2

High-throughput

0.609

High

618210

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

1

High-throughput

0.609

High

519592

LYAG
Lysosomal alpha-glucosidase

2

0

High-throughput

0.602

High

539863

RALB
Ras-related protein Ral-B

2

0

High-throughput

0.602

High

618178

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.536

High

618184

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.536

High

618199

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

1

High-throughput

0.536

High

618209

CBLN4
Cerebellin-4

1

3

High-throughput

0.536

High

618181

TSC2
Tuberin

1

0

Small-scale

0.529

High

296871

RASF9
Ras association domain-containing protein 9

1

1

Small-scale

0.527

High

506822

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

518808

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

547964

PSPC
Surfactant protein C

1

0

High-throughput

0.513

High

567796

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

593270

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

618183

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

0

High-throughput

0.513

High

618194

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

618204

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.513

High

618177

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

1

High-throughput

0.489

High

618190

CL12B
C-type lectin domain family 12 member B

1

1

High-throughput

0.489

High

618197

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.489

High

618205

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

3

High-throughput

0.489

High

618206

KLK15
Kallikrein-15

1

2

High-throughput

0.489

High

618211

BTNL2
Butyrophilin-like protein 2

1

3

High-throughput

0.489

High

238799

KALRN
Kalirin

1

1

Small-scale

0.481

High

530991

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

High-throughput

0.479

High

618192

SUSD4
Sushi domain-containing protein 4

1

1

High-throughput

0.479

High

618193

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

618180

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.460

High

618207

DPEP2
Dipeptidase 2

1

0

High-throughput

0.458

High

618201

CA054
Uncharacterized protein C1orf54

1

1

High-throughput

0.445

High

618202

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.445

High

217810

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

618182

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

Small-scale

0.437

High

618179

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

618185

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

618191

Q5J1K9
Mono-ADP-ribosyltransferase 3 variant Ia

1

1

High-throughput

0.407

High

618198

ZNT7
Zinc transporter 7

1

1

High-throughput

0.407

High

618212

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

618186

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

618203

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

618213

ST14
Suppressor of tumorigenicity 14 protein

1

0

High-throughput

0.279

Low

289069

DEDD
Death effector domain-containing protein

1

0

High-throughput

0.249

Low

618208

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

2091

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

618200

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025