Protein: LYAG
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]

Gene: LYAG, GAA
Organism: Homo sapiens
Interactions: 116
UniProt ID: P10253

Gene Ontology (top 5):
GO:0000023 - maltose metabolic process
GO:0002026 - regulation of the force of heart contraction
GO:0002086 - diaphragm contraction
GO:0003007 - heart morphogenesis
GO:0004558 - alpha-1,4-glucosidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

519624

B4GN3
Beta-1,4-N-acetylgalactosaminyltransferase 3

2

0

High-throughput

0.770

High

519611

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.691

High

519657

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

3

High-throughput

0.691

High

519589

B4GT1
Beta-1,4-galactosyltransferase 1

2

1

High-throughput

0.628

High

519595

MA2A2
Alpha-mannosidase 2x

2

1

High-throughput

0.628

High

519637

GALT4
Polypeptide N-acetylgalactosaminyltransferase 4

2

1

High-throughput

0.628

High

519664

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

2

2

High-throughput

0.628

High

519674

B4GT7
Beta-1,4-galactosyltransferase 7

2

1

High-throughput

0.628

High

282816

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.618

High

316477

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

2

0

High-throughput

0.602

High

519592

AMD
Peptidyl-glycine alpha-amidating monooxygenase

2

0

High-throughput

0.602

High

519619

T132A
Transmembrane protein 132A

2

0

High-throughput

0.602

High

519593

CALX
Calnexin

2

7

High-throughput

0.601

High

519601

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

2

2

High-throughput

0.601

High

519677

FBX2
F-box only protein 2

2

4

High-throughput

0.601

High

519615

MSMO1
Methylsterol monooxygenase 1

2

0

High-throughput

0.576

High

519616

EXT1
Exostosin-1

2

1

High-throughput

0.574

High

519620

LRC24
Leucine-rich repeat-containing protein 24

2

3

High-throughput

0.574

High

519640

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.574

High

519668

FBX6
F-box only protein 6

2

4

High-throughput

0.571

High

519629

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.553

High

519653

CNT3B
Contactin-associated protein-like 3B

2

2

High-throughput

0.552

High

170636

CLGN
Calmegin

2

7

High-throughput

0.549

High

160980

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.536

High

276991

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

2

High-throughput

0.536

High

337525

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

1

High-throughput

0.536

High

519582

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.536

High

519583

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.536

High

519586

ADT1
ADP/ATP translocase 1

1

2

High-throughput

0.536

High

519602

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

5

High-throughput

0.536

High

519603

MFGM
Lactadherin

1

3

High-throughput

0.536

High

519618

MA2A1
Alpha-mannosidase 2

1

1

High-throughput

0.536

High

519622

METRL
Meteorin-like protein

1

1

High-throughput

0.536

High

519631

GALT7
N-acetylgalactosaminyltransferase 7

1

1

High-throughput

0.536

High

519636

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

1

High-throughput

0.536

High

519643

CHSTE
Carbohydrate sulfotransferase 14

1

1

High-throughput

0.536

High

519649

EXT2
Exostosin-2

1

1

High-throughput

0.536

High

519654

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

3

High-throughput

0.536

High

519658

CNTP3
Contactin-associated protein-like 3

1

3

High-throughput

0.536

High

519667

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.536

High

519673

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.536

High

519678

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.536

High

519597

STAT2
Signal transducer and activator of transcription 2

1

0

High-throughput

0.518

High

519587

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.515

High

320859

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

0

High-throughput

0.513

High

447963

ITAV
Integrin alpha-V

1

0

High-throughput

0.513

High

519585

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.513

High

519594

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.513

High

519600

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

519604

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.513

High

519606

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

519612

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.513

High

519613

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

519617

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

519660

LMA2L
VIP36-like protein

1

0

High-throughput

0.513

High

519662

SEM6B
Semaphorin-6B

1

0

High-throughput

0.513

High

519663

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.513

High

519672

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.513

High

519680

JAG2
Protein jagged-2

1

0

High-throughput

0.513

High

519626

PLGT2
Protein O-glucosyltransferase 2

1

1

High-throughput

0.489

High

519628

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.489

High

519635

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.489

High

519641

RDH13
Retinol dehydrogenase 13

1

2

High-throughput

0.489

High

519671

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.489

High

519676

METRN
Meteorin

1

1

High-throughput

0.489

High

519681

DJC16
DnaJ homolog subfamily C member 16

1

8

High-throughput

0.489

High

519588

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.481

High

411243

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

519584

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

519598

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

519627

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

519646

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

519669

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

519675

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

210521

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.460

High

519599

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.460

High

519666

SHLB2
Endophilin-B2

1

0

High-throughput

0.460

High

519634

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

409231

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.445

High

519607

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.445

High

519609

OS9
Protein OS-9

1

1

High-throughput

0.445

High

519650

S67A1
Solute carrier family 67 member A1

1

1

High-throughput

0.445

High

519655

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

519682

PRG3
Proteoglycan 3

1

1

High-throughput

0.445

High

519590

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.439

High

519605

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.439

High

519647

CBP
CREB-binding protein

1

3

Small-scale

0.439

High

413063

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

519591

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

519623

NCLX
Mitochondrial sodium/calcium exchanger protein

1

0

High-throughput

0.426

High

519625

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

519642

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.426

High

519651

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.407

High

519652

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.407

High

519621

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

0

High-throughput

0.328

High

519632

DYR2
Dihydrofolate reductase 2, mitochondrial

2

0

High-throughput

0.328

High

519638

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

327100

NXPH4
Neurexophilin-4

1

0

High-throughput

0.279

Low

519596

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

519633

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.279

Low

519639

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

519656

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.279

Low

519661

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

519670

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.279

Low

519679

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.279

Low

519630

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

519644

PAR3L
Partitioning defective 3 homolog B

1

0

High-throughput

0.251

Low

519683

NUMBL
Numb-like protein

1

0

High-throughput

0.251

Low

519610

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

519659

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

330024

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

519608

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

519614

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.232

Low

519645

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.232

Low

519648

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.232

Low

519665

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025