Protein: AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]

Gene: AASS
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q9UDR5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0004753 - saccharopine dehydrogenase activity
GO:0004754 - saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

373398

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

1123470

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

1310494

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

186098

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

243198

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

279961

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

404516

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

691514

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

730324

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

730938

1433S
14-3-3 protein sigma

1

6

High-throughput

0.479

High

828999

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

955717

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

966980

1433G
14-3-3 protein gamma

1

6

High-throughput

0.479

High

990833

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

1015879

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

1049874

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

1090581

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1291599

HOOK3
Protein Hook homolog 3

1

2

High-throughput

0.479

High

1450460

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1458910

HOOK1
Protein Hook homolog 1

1

1

High-throughput

0.479

High

471302

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

487850

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

519261

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

533039

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

560125

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

589944

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696766

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

831584

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

972096

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1048746

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1114551

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1117874

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1141996

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1142698

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1150015

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

1162605

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1207175

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1255945

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1337387

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.458

High

1397524

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1403466

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1415700

TR61B
tRNA

1

0

High-throughput

0.458

High

1434139

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435822

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1446482

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

1458909

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

638543

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.445

High

669371

ACKR3
Atypical chemokine receptor 3

1

1

High-throughput

0.445

High

886149

CXCR3
C-X-C chemokine receptor type 3

1

1

High-throughput

0.445

High

1272441

GET4
Golgi to ER traffic protein 4 homolog

1

1

High-throughput

0.445

High

1391828

AURKB
Aurora kinase B

1

1

High-throughput

0.445

High

650587

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

0

High-throughput

0.426

High

1251894

CCNI2
Cyclin-I2

1

0

High-throughput

0.426

High

1416305

SFXN3
Sideroflexin-3

1

0

High-throughput

0.426

High

1453751

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.426

High

1294314

VP37D
Vacuolar protein sorting-associated protein 37D

2

0

High-throughput

0.328

High

1142205

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1326806

ARG39
Rho guanine nucleotide exchange factor 39

1

0

High-throughput

0.279

Low

1349141

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1458911

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

189025

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.249

Low

769419

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1326371

NIN
Ninein

1

0

High-throughput

0.249

Low

2127

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

510091

S352B
Solute carrier family 35 member E2B

1

0

High-throughput

0.232

Low

634813

GRAH
Granzyme H

1

0

High-throughput

0.232

Low

652263

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

0

High-throughput

0.232

Low

754117

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

880216

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.232

Low

1316390

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.232

Low

1325941

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.232

Low

1350611

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.232

Low

1432215

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.232

Low

1446081

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025