Protein: SENP5
Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5)

Gene: SENP5
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q96HI0

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006508 - proteolysis
GO:0016925 - protein sumoylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

447315

NPM
Nucleophosmin

4

3

High-throughput

0.699

High

288732

NPM3
Nucleoplasmin-3

3

3

High-throughput

0.662

High

939223

SUMO3
Small ubiquitin-related modifier 3

1

20

Small-scale

0.647

High

964415

SUMO2
Small ubiquitin-related modifier 2

1

20

Small-scale

0.647

High

239171

ZNRD2
Protein ZNRD2

3

0

High-throughput

0.634

High

1110534

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.628

High

1393267

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

1

High-throughput

0.628

High

945945

LOXL3
Lysyl oxidase homolog 3

2

1

High-throughput

0.611

High

169265

CASQ2
Calsequestrin-2

3

1

High-throughput

0.609

High

1393262

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.602

High

1393265

FEM1B
Protein fem-1 homolog B

2

2

High-throughput

0.601

High

1325593

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

0

High-throughput

0.585

High

1393263

DKK3
Dickkopf-related protein 3

2

1

High-throughput

0.574

High

396709

ESR1
Estrogen receptor

1

6

Small-scale

0.552

High

391405

FRIL
Ferritin light chain

2

1

High-throughput

0.549

High

317362

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.536

High

338932

CBX6
Chromobox protein homolog 6

1

8

High-throughput

0.536

High

407687

S100B
Protein S100-B

1

4

High-throughput

0.536

High

848699

MAGA9
Melanoma-associated antigen 9

1

3

High-throughput

0.536

High

905464

HCFC1
Host cell factor 1

1

2

High-throughput

0.536

High

1047691

NOTC2
Neurogenic locus notch homolog protein 2

1

1

High-throughput

0.536

High

1393256

ZN333
Zinc finger protein 333

1

1

High-throughput

0.536

High

1393268

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

1372262

H2B1H
Histone H2B type 1-H

1

5

High-throughput

0.515

High

261542

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

880055

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1054629

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.513

High

1180953

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.513

High

1382514

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

706259

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

997085

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.489

High

1103726

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

1

High-throughput

0.489

High

1132127

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

2

High-throughput

0.489

High

1213676

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.489

High

1360035

OIT3
Oncoprotein-induced transcript 3 protein

1

4

High-throughput

0.489

High

1393264

FBLN5
Fibulin-5

1

5

High-throughput

0.489

High

1393260

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.479

High

414408

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

714352

PML
Protein PML

1

7

High-throughput

0.479

High

913795

ZN131
Zinc finger protein 131

1

3

High-throughput

0.479

High

1096786

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1292796

SKAP1
Src kinase-associated phosphoprotein 1

1

2

High-throughput

0.479

High

1352117

ATS19
A disintegrin and metalloproteinase with thrombospondin motifs 19

1

1

High-throughput

0.479

High

1393259

ELF4
ETS-related transcription factor Elf-4

1

2

High-throughput

0.479

High

194298

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

1331391

CDYL2
Chromodomain Y-like protein 2

1

0

High-throughput

0.458

High

1393258

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.458

High

1393269

RBGP1
Rab GTPase-activating protein 1

1

1

Small-scale

0.457

High

1112955

CUL2
Cullin-2

1

8

High-throughput

0.445

High

1393270

HCFC2
Host cell factor 2

1

2

High-throughput

0.445

High

85918

B9A025
Lysyl oxidase homolog

1

1

High-throughput

0.407

High

259045

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.279

Low

1057110

FMOD
Fibromodulin

1

0

High-throughput

0.279

Low

1219987

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1230199

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.279

Low

1292665

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

1359093

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low

1364786

TICN2
Testican-2

1

0

High-throughput

0.279

Low

1393257

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

1393266

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

1201322

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

456001

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.249

Low

1257313

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

1

0

High-throughput

0.249

Low

1393261

TMM79
Transmembrane protein 79

1

0

Small-scale

0.249

Low

58901

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025