Protein: GRPE1
GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)

Gene: GRPE1, GRPEL1
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q9HAV7

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0001405 - PAM complex, Tim23 associated import motor
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

801536

HSPA9
Stress-70 protein, mitochondrial

7

5

High-throughput

0.962

High

1346598

GRPE2
GrpE protein homolog 2, mitochondrial

4

5

High-throughput

0.892

High

1437798

GRPE1
GrpE protein homolog 1, mitochondrial

3

5

Small-scale

0.855

High

1360087

PALLD
Palladin

3

0

High-throughput

0.638

High

1434869

DEN2D
DENN domain-containing protein 2D

3

0

High-throughput

0.638

High

1310422

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

564390

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.602

High

1292082

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.602

High

180404

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.589

High

1123435

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

373189

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1162561

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

622480

ELK1
ETS domain-containing protein Elk-1

2

6

High-throughput

0.571

High

711420

SHC1
SHC-transforming protein 1

2

1

High-throughput

0.571

High

279922

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1209675

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

902081

RAB9A
Ras-related protein Rab-9A

2

1

High-throughput

0.537

High

583605

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

1405002

EYA1
Protein phosphatase EYA1

1

1

High-throughput

0.536

High

193629

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

1

High-throughput

0.521

High

1102373

GRB10
Growth factor receptor-bound protein 10

2

1

High-throughput

0.521

High

1327794

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.521

High

317531

TPPP
Tubulin polymerization-promoting protein

1

0

High-throughput

0.513

High

555431

SKI
Ski oncogene

1

0

High-throughput

0.513

High

690559

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

425633

ISG15
Ubiquitin-like protein ISG15

1

1

Small-scale

0.501

High

1120125

RB33A
Ras-related protein Rab-33A

1

1

High-throughput

0.489

High

1042926

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.480

High

1381241

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.480

High

143266

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

274762

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.479

High

282091

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

298959

DNJB5
DnaJ homolog subfamily B member 5

1

2

High-throughput

0.479

High

348744

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

401510

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

406663

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

471259

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

474302

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

607117

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

631485

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

679401

DNJB2
DnaJ homolog subfamily B member 2

1

6

High-throughput

0.479

High

702378

ELK4
ETS domain-containing protein Elk-4

1

6

High-throughput

0.479

High

739034

ELF1
ETS-related transcription factor Elf-1

1

7

High-throughput

0.479

High

828967

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

832496

ETV5
ETS translocation variant 5

1

7

High-throughput

0.479

High

837094

ELK3
ETS domain-containing protein Elk-3

1

7

High-throughput

0.479

High

846936

ETV4
ETS translocation variant 4

1

7

High-throughput

0.479

High

856389

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

882897

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

1008566

ELF3
ETS-related transcription factor Elf-3

1

7

High-throughput

0.479

High

1083759

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1088030

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1115074

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1117848

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1141948

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1234533

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1280306

DNJB7
DnaJ homolog subfamily B member 7

1

9

High-throughput

0.479

High

1340518

DNJB8
DnaJ homolog subfamily B member 8

1

9

High-throughput

0.479

High

1358961

DNJA4
DnaJ homolog subfamily A member 4

1

3

High-throughput

0.479

High

1359392

DNJB3
DnaJ homolog subfamily B member 3

1

8

High-throughput

0.479

High

1383562

MCUR1
Mitochondrial calcium uniporter regulator 1

1

2

High-throughput

0.479

High

1386024

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1389903

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

3

High-throughput

0.479

High

1397169

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

9

High-throughput

0.479

High

1405014

EYA3
Protein phosphatase EYA3

1

1

High-throughput

0.479

High

1416549

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1428808

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

2

High-throughput

0.479

High

1433724

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1437799

DNJC4
DnaJ homolog subfamily C member 4

1

8

High-throughput

0.479

High

1437804

DJC11
DnaJ homolog subfamily C member 11

1

9

High-throughput

0.479

High

1437808

DJC27
DnaJ homolog subfamily C member 27

1

1

High-throughput

0.479

High

61645

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

380150

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

386248

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

400022

CATA
Catalase

1

0

High-throughput

0.458

High

412635

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

517498

GLI2
Zinc finger protein GLI2

1

0

High-throughput

0.458

High

519233

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

621526

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

681037

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

693094

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

719373

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

766867

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

799483

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

822868

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

852037

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

927141

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

928554

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.458

High

941270

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

957521

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

979256

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

998826

H31
Histone H3.1

1

0

High-throughput

0.458

High

1024193

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048705

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058286

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090549

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1194387

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1207148

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1229689

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1311728

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.458

High

1391774

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1399850

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1401626

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1403434

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1406695

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.458

High

1418888

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1432312

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1435789

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436091

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1436936

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1437801

ANM8
Protein arginine N-methyltransferase 8

1

0

Small-scale

0.458

High

1437802

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1437805

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1437809

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1437810

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

1437811

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1437814

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

430377

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

653578

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

833025

ETV6
Transcription factor ETV6

1

5

High-throughput

0.437

High

1133672

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.437

High

1229374

LHX8
LIM/homeobox protein Lhx8

1

1

High-throughput

0.437

High

1251349

DJC14
DnaJ homolog subfamily C member 14

1

9

High-throughput

0.437

High

1349035

DJB14
DnaJ homolog subfamily B member 14

1

8

High-throughput

0.437

High

1379951

LHX4
LIM/homeobox protein Lhx4

1

1

High-throughput

0.437

High

1436051

DJC18
DnaJ homolog subfamily C member 18

1

9

High-throughput

0.437

High

1437806

DJB12
DnaJ homolog subfamily B member 12

1

6

High-throughput

0.437

High

1437812

DJC16
DnaJ homolog subfamily C member 16

1

6

High-throughput

0.437

High

1437813

NINL
Ninein-like protein

1

1

High-throughput

0.437

High

330327

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

598777

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

728686

IL2RG
Cytokine receptor common subunit gamma

1

0

High-throughput

0.426

High

967980

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

1023891

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

1104114

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1119311

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1382666

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

1399663

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

1

0

High-throughput

0.426

High

1401875

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1415677

TR61B
tRNA

1

0

High-throughput

0.426

High

1420718

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1437803

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1292674

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

462165

GALT
Galactose-1-phosphate uridylyltransferase

2

0

High-throughput

0.316

High

1180025

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

1437807

SPG21
Maspardin

2

0

High-throughput

0.316

High

976573

RB11A
Ras-related protein Rab-11A

2

0

High-throughput

0.307

High

1384271

SH3K1
SH3 domain-containing kinase-binding protein 1

2

0

High-throughput

0.298

High

1399097

SCLT1
Sodium channel and clathrin linker 1

2

0

High-throughput

0.298

High

488191

IFIT1
Antiviral innate immune response effector IFIT1

1

0

High-throughput

0.279

Low

505110

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

1347872

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

1437815

MTL5
Tesmin

1

0

High-throughput

0.279

Low

180055

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

409088

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.249

Low

540684

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.249

Low

767339

MERL
Merlin

1

0

High-throughput

0.249

Low

1015801

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1063625

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1091348

FOXL1
Forkhead box protein L1

1

0

High-throughput

0.249

Low

1096640

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

Small-scale

0.249

Low

1133412

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

0

High-throughput

0.249

Low

1255605

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1433934

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

295541

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

High-throughput

0.232

Low

1437800

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025