Protein: TYSY
Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

Gene: TYSY, TYMS
Organism: Homo sapiens
Interactions: 56
UniProt ID: P04818

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0004799 - thymidylate synthase activity
GO:0005542 - folic acid binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416739

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

3

0

High-throughput

0.638

High

416729

TYSY
Thymidylate synthase

1

2

High-throughput

0.618

High

416774

IPKG
cAMP-dependent protein kinase inhibitor gamma

2

0

High-throughput

0.602

High

261754

PFD1
Prefoldin subunit 1

2

0

High-throughput

0.576

High

416731

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

416763

SNAG
Gamma-soluble NSF attachment protein

1

0

High-throughput

0.513

High

416773

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.513

High

416765

SH3G2
Endophilin-A1

1

0

High-throughput

0.486

High

416741

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

47945

RBM47
RNA-binding protein 47

1

1

High-throughput

0.479

High

373725

RASN
GTPase NRas

1

1

High-throughput

0.479

High

375077

RASK
GTPase KRas

1

1

High-throughput

0.479

High

416767

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

240469

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

370133

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

385354

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

416732

PABP1
Polyadenylate-binding protein 1

1

0

High-throughput

0.458

High

416734

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

416736

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

416737

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

416742

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

416743

H31
Histone H3.1

1

0

High-throughput

0.458

High

416744

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

416746

ILF3
Interleukin enhancer-binding factor 3

1

0

Small-scale

0.458

High

416749

FTM
Protein fantom

1

0

High-throughput

0.458

High

416750

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

416751

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

416752

DET1
DET1 homolog

1

0

High-throughput

0.458

High

416753

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

416757

POC5
Centrosomal protein POC5

1

0

High-throughput

0.458

High

416758

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

416760

POC1B
POC1 centriolar protein homolog B

1

0

High-throughput

0.458

High

416762

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

416766

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

416748

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

246271

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

2

High-throughput

0.437

High

416754

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

2

High-throughput

0.437

High

416772

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

2

High-throughput

0.437

High

416745

NPT2A
Sodium-dependent phosphate transport protein 2A

1

0

High-throughput

0.426

High

416769

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

Small-scale

0.426

High

416735

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

64169

ARG35
Rho guanine nucleotide exchange factor 35

1

0

High-throughput

0.279

Low

416747

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

416756

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

416759

PSD4
PH and SEC7 domain-containing protein 4

1

0

High-throughput

0.279

Low

416768

TANC2
Protein TANC2

1

0

High-throughput

0.279

Low

416761

EFHD2
EF-hand domain-containing protein D2

1

0

High-throughput

0.269

Low

416730

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

416733

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

416738

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

416740

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

416755

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

416764

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.249

Low

416770

BFAR
Bifunctional apoptosis regulator

1

0

High-throughput

0.249

Low

416771

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025