Protein: TF3C4
General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta)

Gene: TF3C4, GTF3C4
Organism: Homo sapiens
Interactions: 174
UniProt ID: Q9UKN8

Gene Ontology (top 5):
GO:0000127 - transcription factor TFIIIC complex
GO:0000995 - RNA polymerase III general transcription initiation factor activity
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356463

TF3C2
General transcription factor 3C polypeptide 2

3

0

Small-scale

0.825

High

373455

MYC
Myc proto-oncogene protein

5

1

High-throughput

0.706

High

1085850

TF3C1
General transcription factor 3C polypeptide 1

4

1

Small-scale

0.696

High

1461188

TF3C5
General transcription factor 3C polypeptide 5

3

1

Small-scale

0.674

High

920351

PLK1
Serine/threonine-protein kinase PLK1

3

1

High-throughput

0.667

High

1461189

TF3C3
General transcription factor 3C polypeptide 3

2

1

Small-scale

0.611

High

1367554

ESR2
Estrogen receptor beta

2

1

High-throughput

0.588

High

285519

EED
Polycomb protein EED

1

0

High-throughput

0.586

High

1436822

WDR76
WD repeat-containing protein 76

1

0

High-throughput

0.586

High

520438

ANDR
Androgen receptor

2

1

High-throughput

0.584

High

998934

H31
Histone H3.1

2

3

High-throughput

0.584

High

1100520

TIF1B
Transcription intermediary factor 1-beta

2

3

Small-scale

0.584

High

1130215

SMC1A
Structural maintenance of chromosomes protein 1A

2

2

Small-scale

0.584

High

1433863

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

2

Small-scale

0.584

High

1461185

SMC3
Structural maintenance of chromosomes protein 3

2

2

Small-scale

0.584

High

69840

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

1414284

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

Small-scale

0.569

High

243257

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

414815

P53
Cellular tumor antigen p53

2

0

High-throughput

0.559

High

980522

H4
Histone H4

2

0

High-throughput

0.559

High

1392754

ZN764
Zinc finger protein 764

2

2

High-throughput

0.549

High

1379897

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.545

High

578320

ETS2
Protein C-ets-2

1

1

High-throughput

0.541

High

221977

FOXS1
Forkhead box protein S1

1

2

High-throughput

0.536

High

505778

ZN688
Zinc finger protein 688

1

3

High-throughput

0.536

High

841031

FRK
Tyrosine-protein kinase FRK

1

2

High-throughput

0.536

High

1014227

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

1061626

FOXM1
Forkhead box protein M1

1

4

High-throughput

0.536

High

1091373

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.536

High

1438664

CBX8
Chromobox protein homolog 8

1

2

High-throughput

0.536

High

1453808

FOXJ2
Forkhead box protein J2

1

2

High-throughput

0.536

High

1327813

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

141163

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

253219

RAD1
Cell cycle checkpoint protein RAD1

1

0

High-throughput

0.513

High

401680

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

447561

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

625698

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

970162

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1006788

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.513

High

1054815

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1130875

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.513

High

1134082

ZN638
Zinc finger protein 638

1

0

High-throughput

0.513

High

1134881

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.513

High

1287901

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

1459612

LIMD1
LIM domain-containing protein 1

1

0

High-throughput

0.513

High

1258973

H32
Histone H3.2

1

3

Small-scale

0.501

High

186597

TRI18
E3 ubiquitin-protein ligase Midline-1

1

1

High-throughput

0.489

High

849269

KSYK
Tyrosine-protein kinase SYK

1

3

High-throughput

0.489

High

920528

DAPK1
Death-associated protein kinase 1

1

1

High-throughput

0.489

High

1401333

PASK
PAS domain-containing serine/threonine-protein kinase

1

1

High-throughput

0.489

High

1407772

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1415065

ZN747
Zinc finger protein 747

1

3

High-throughput

0.489

High

1420519

FOXQ1
Forkhead box protein Q1

1

3

High-throughput

0.489

High

799566

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

170420

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

628856

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

964505

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1431040

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

Small-scale

0.480

High

277847

H2AY
Core histone macro-H2A.1

1

1

High-throughput

0.479

High

316140

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

362404

ABL1
Tyrosine-protein kinase ABL1

1

2

High-throughput

0.479

High

406782

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

473171

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

608784

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

634690

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

714510

PML
Protein PML

1

3

High-throughput

0.479

High

755024

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

755817

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.479

High

862537

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

883730

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

888383

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

937367

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

981174

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1008933

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

1017288

H33
Histone H3.3

1

3

High-throughput

0.479

High

1097623

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1128309

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

1161749

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1235566

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1287029

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1404829

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1406802

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.479

High

1414720

MET22
Methyltransferase-like protein 22

1

1

High-throughput

0.479

High

1461187

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.479

High

129536

MEN1
Menin

1

0

High-throughput

0.458

High

191154

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

194387

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

260596

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

412786

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

419266

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.458

High

558481

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

607209

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

664827

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

766931

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

800161

COIL
Coilin

1

0

High-throughput

0.458

High

881623

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

1005233

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1026583

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1033813

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1089061

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1106391

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

1114620

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1137577

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1155891

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1271234

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

1280588

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1289706

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1329935

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1352824

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1390548

CDCA5
Sororin

1

0

High-throughput

0.458

High

1401439

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

1415907

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1433800

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

1435434

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1437236

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1447419

ANLN
Anillin

1

0

High-throughput

0.458

High

1452471

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1453038

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1454352

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1459263

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1461183

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1461190

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.458

High

1448548

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

157972

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

244030

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.437

High

840991

ABL2
Tyrosine-protein kinase ABL2

1

2

High-throughput

0.437

High

1219801

MT21C
Protein-lysine methyltransferase METTL21C

1

1

High-throughput

0.437

High

1256038

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1434198

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1449048

HELLS
Lymphoid-specific helicase

1

2

Small-scale

0.437

High

294762

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

1111350

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1209779

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1239978

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1420759

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1461181

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

176725

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.279

Low

1013353

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1112464

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.279

Low

1288292

LYRIC
Protein LYRIC

1

0

High-throughput

0.279

Low

1432512

PABP3
Polyadenylate-binding protein 3

1

0

High-throughput

0.279

Low

1434508

ZN644
Zinc finger protein 644

1

0

High-throughput

0.279

Low

1448478

SNRK
SNF-related serine/threonine-protein kinase

1

0

High-throughput

0.279

Low

1448708

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.279

Low

1450760

FAIM1
Fas apoptotic inhibitory molecule 1

1

0

High-throughput

0.279

Low

1458914

CLIP2
CAP-Gly domain-containing linker protein 2

1

0

High-throughput

0.279

Low

1461184

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.279

Low

1461186

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

61766

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.249

Low

106829

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

320135

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

353620

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

995886

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1024920

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1091474

ANK3
Ankyrin-3

1

0

High-throughput

0.249

Low

1133727

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.249

Low

1135480

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

0

High-throughput

0.249

Low

1135850

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1141015

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1178456

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1258411

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1276945

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1324108

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1327260

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1338426

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1393816

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1397543

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1432104

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.249

Low

1458284

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

0

High-throughput

0.249

Low

1458821

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low

1461182

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

354800

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low

1430458

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low

1437399

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025