Protein: CRTC2
CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)

Gene: CRTC2
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q53ET0

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

593125

CREB1
Cyclic AMP-responsive element-binding protein 1

2

2

High-throughput

0.783

High

729892

1433B
14-3-3 protein beta/alpha

8

20

Small-scale

0.749

High

691068

1433T
14-3-3 protein theta

8

20

Small-scale

0.747

High

966400

1433G
14-3-3 protein gamma

6

20

High-throughput

0.737

High

990294

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.704

High

1049358

1433F
14-3-3 protein eta

4

20

High-throughput

0.697

High

971593

1433E
14-3-3 protein epsilon

3

6

High-throughput

0.675

High

873468

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

3

7

High-throughput

0.662

High

1198346

SIK2
Serine/threonine-protein kinase SIK2

2

6

Small-scale

0.629

High

989906

CANB1
Calcineurin subunit B type 1

2

1

High-throughput

0.628

High

1198343

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.628

High

617307

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

8

Small-scale

0.618

High

1179948

CCD57
Coiled-coil domain-containing protein 57

2

5

High-throughput

0.606

High

1198356

CDC23
Cell division cycle protein 23 homolog

2

5

High-throughput

0.606

High

1198358

SUFU
Suppressor of fused homolog

2

1

High-throughput

0.606

High

1198333

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.575

High

1144361

NONO
Non-POU domain-containing octamer-binding protein

1

1

Small-scale

0.561

High

593847

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

7

High-throughput

0.536

High

958283

ARP2
Actin-related protein 2

1

6

High-throughput

0.536

High

1026067

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.536

High

1198347

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1198350

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.536

High

552977

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

861637

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

8

High-throughput

0.501

High

1095384

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

4

Small-scale

0.501

High

1198361

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

5

High-throughput

0.501

High

172888

XPO1
Exportin-1

1

11

High-throughput

0.479

High

377592

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.479

High

378496

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

413955

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

998388

H31
Histone H3.1

1

18

Small-scale

0.479

High

1028231

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1047987

TLE3
Transducin-like enhancer protein 3

1

6

High-throughput

0.479

High

1062376

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

8

Small-scale

0.479

High

1063779

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.479

High

1067419

EP300
Histone acetyltransferase p300

1

19

Small-scale

0.479

High

1128999

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

2

Small-scale

0.479

High

1198334

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

6

High-throughput

0.479

High

1198335

KSR1
Kinase suppressor of Ras 1

1

9

High-throughput

0.479

High

1198338

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1198339

NEDD1
Protein NEDD1

1

4

High-throughput

0.479

High

1198340

COP1
E3 ubiquitin-protein ligase COP1

1

9

Small-scale

0.479

High

1198341

HDAC2
Histone deacetylase 2

1

11

High-throughput

0.479

High

1198342

CBP
CREB-binding protein

1

17

Small-scale

0.479

High

1198344

CP250
Centrosome-associated protein CEP250

1

6

High-throughput

0.479

High

1198349

KI13B
Kinesin-like protein KIF13B

1

6

High-throughput

0.479

High

1198353

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.479

High

1198354

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1198355

XPO7
Exportin-7

1

11

High-throughput

0.479

High

1198357

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

1198360

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1198362

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.479

High

808083

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

1198331

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1198345

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

137132

MEIS1
Homeobox protein Meis1

1

1

Small-scale

0.445

High

943651

SIK1
Serine/threonine-protein kinase SIK1

1

6

Small-scale

0.445

High

1198359

SIK3
Serine/threonine-protein kinase SIK3

1

5

Small-scale

0.445

High

281333

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

1198348

RC3H2
Roquin-2

1

10

High-throughput

0.437

High

1198352

CING
Cingulin

1

1

High-throughput

0.437

High

1198363

KCTD3
BTB/POZ domain-containing protein KCTD3

1

7

High-throughput

0.437

High

1198332

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

1198336

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.316

High

1198337

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.279

Low

1198351

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025