Protein: ARPC2
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)

Gene: ARPC2
Organism: Homo sapiens
Interactions: 160
UniProt ID: O15144

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

179330

ARP3
Actin-related protein 3

13

6

Small-scale

0.978

High

179331

ARP2
Actin-related protein 2

11

6

High-throughput

0.975

High

179408

ARP3B
Actin-related protein 3B

6

6

High-throughput

0.950

High

179327

ARPC4
Actin-related protein 2/3 complex subunit 4

5

3

Small-scale

0.928

High

179328

ACTB
Actin, cytoplasmic 1

2

2

High-throughput

0.789

High

179335

ACTG
Actin, cytoplasmic 2

2

2

High-throughput

0.789

High

179092

ARC1B
Actin-related protein 2/3 complex subunit 1B

15

4

Small-scale

0.763

High

179386

ARC1A
Actin-related protein 2/3 complex subunit 1A

11

4

Small-scale

0.758

High

179270

ARPC3
Actin-related protein 2/3 complex subunit 3

9

2

Small-scale

0.751

High

179271

ARPC5
Actin-related protein 2/3 complex subunit 5

5

3

Small-scale

0.714

High

179390

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

3

3

Small-scale

0.660

High

179402

ANLN
Anillin

3

1

High-throughput

0.656

High

179299

CFTR
Cystic fibrosis transmembrane conductance regulator

3

0

High-throughput

0.622

High

179346

SRC8
Src substrate cortactin

2

2

Small-scale

0.611

High

179353

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

Small-scale

0.577

High

179297

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.576

High

179357

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

Small-scale

0.571

High

179276

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

179279

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

179325

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.547

High

179385

ESR2
Estrogen receptor beta

2

0

High-throughput

0.547

High

179394

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.541

High

179319

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

179320

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

179338

CALD1
Caldesmon

1

2

High-throughput

0.536

High

179343

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.536

High

179354

DREB
Drebrin

1

1

High-throughput

0.536

High

179360

CYTSA
Cytospin-A

1

2

High-throughput

0.536

High

179388

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.536

High

179391

COR1B
Coronin-1B

1

1

Small-scale

0.536

High

179403

MYO5C
Unconventional myosin-Vc

1

3

High-throughput

0.536

High

179412

DBNL
Drebrin-like protein

1

3

High-throughput

0.536

High

179273

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.513

High

179308

1433B
14-3-3 protein beta/alpha

1

0

High-throughput

0.513

High

179312

MYH9
Myosin-9

1

0

High-throughput

0.513

High

179313

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.513

High

179318

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

179323

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

179332

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.513

High

179344

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

179345

BOP1
Ribosome biogenesis protein BOP1

1

0

High-throughput

0.513

High

179347

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

179351

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

179355

CL16A
Protein CLEC16A

1

0

High-throughput

0.513

High

179372

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

179374

AL14E
ARL14 effector protein

1

0

High-throughput

0.513

High

179379

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

High-throughput

0.513

High

179389

ZN830
Zinc finger protein 830

1

0

High-throughput

0.513

High

179392

KIFC1
Kinesin-like protein KIFC1

1

0

High-throughput

0.513

High

179404

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

179405

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.513

High

179409

STK26
Serine/threonine-protein kinase 26

1

0

High-throughput

0.513

High

179413

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.513

High

179415

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.513

High

179421

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

169821

AURKA
Aurora kinase A

1

1

Small-scale

0.501

High

179316

WASP
Actin nucleation-promoting factor WAS

1

6

Small-scale

0.501

High

179367

ARPIN
Arpin

1

0

Small-scale

0.493

High

179417

SIK3
Serine/threonine-protein kinase SIK3

1

1

High-throughput

0.489

High

126369

RHOD
Rho-related GTP-binding protein RhoD

1

2

High-throughput

0.479

High

133606

WASL
Actin nucleation-promoting factor WASL

1

5

Small-scale

0.479

High

136027

PLK4
Serine/threonine-protein kinase PLK4

1

2

Small-scale

0.479

High

179282

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

179283

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

179295

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.479

High

179309

RYK
Tyrosine-protein kinase RYK

1

1

High-throughput

0.479

High

179314

PPARG
Peroxisome proliferator-activated receptor gamma

1

1

Small-scale

0.479

High

179322

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.479

High

179324

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

179329

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

179349

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

179364

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

179366

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.479

High

179368

PHLB2
Pleckstrin homology-like domain family B member 2

1

1

High-throughput

0.479

High

179371

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

179376

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

179380

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.479

High

179382

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

179399

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

179401

MYO10
Unconventional myosin-X

1

3

Small-scale

0.479

High

179406

RNF12
E3 ubiquitin-protein ligase RLIM

1

1

High-throughput

0.479

High

179416

RNF6
E3 ubiquitin-protein ligase RNF6

1

1

High-throughput

0.479

High

179419

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

172265

XPO1
Exportin-1

1

0

High-throughput

0.458

High

178100

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

179272

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.458

High

179274

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

179275

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

179278

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

179281

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

179284

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

179285

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

179286

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

179289

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

179290

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

179292

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

179293

GLI1
Zinc finger protein GLI1

1

0

Small-scale

0.458

High

179298

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

179300

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

179301

VINC
Vinculin

1

0

Small-scale

0.458

High

179302

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

179303

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

179304

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

179306

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

179307

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

179311

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

179315

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

179317

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

179321

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

179326

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

179333

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

179339

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

179341

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

179342

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

179348

CUL7
Cullin-7

1

0

High-throughput

0.458

High

179350

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

179352

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

179359

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

179362

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

179363

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

0

High-throughput

0.458

High

179370

CEP97
Centrosomal protein of 97 kDa

1

0

Small-scale

0.458

High

179375

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.458

High

179377

PARD3
Partitioning defective 3 homolog

1

0

Small-scale

0.458

High

179381

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

Small-scale

0.458

High

179393

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

179395

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

179397

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.458

High

179398

SHRPN
Sharpin

1

0

Small-scale

0.458

High

179400

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

179410

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

179411

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

179418

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

46390

A0A1W2PNV4
Actin-related protein 2/3 complex subunit 1A

1

4

High-throughput

0.445

High

179288

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

179294

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.445

High

179296

CALM3
Calmodulin-3

1

2

High-throughput

0.445

High

179310

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

179337

RHOG
Rho-related GTP-binding protein RhoG

1

1

Small-scale

0.445

High

179383

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

179396

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

179414

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

179277

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

179305

CXCR2
C-X-C chemokine receptor type 2

1

0

Small-scale

0.426

High

179334

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.426

High

179340

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

179361

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.426

High

179384

SSH1
Protein phosphatase Slingshot homolog 1

1

0

Small-scale

0.426

High

179280

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.279

Low

179336

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

179373

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.279

Low

179387

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

179420

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

179287

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

179291

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

179356

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

179365

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

179369

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

179378

CHUR
Protein Churchill

1

0

High-throughput

0.249

Low

179407

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

179358

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025