Protein: EFHC2
EF-hand domain-containing family member C2

Gene: EFHC2
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q5JST6

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005879 - axonemal microtubule
GO:0010975 - regulation of neuron projection development
GO:0030317 - flagellated sperm motility
GO:0036064 - ciliary basal body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1206423

TSSK3
Testis-specific serine/threonine-protein kinase 3

3

4

High-throughput

0.675

High

131557

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

3

0

High-throughput

0.646

High

1206386

EFHC1
EF-hand domain-containing protein 1

3

0

High-throughput

0.646

High

853805

MK09
Mitogen-activated protein kinase 9

4

11

High-throughput

0.637

High

1118410

PTK6
Protein-tyrosine kinase 6

4

1

High-throughput

0.637

High

1206409

CCHCR
Coiled-coil alpha-helical rod protein 1

4

1

High-throughput

0.637

High

1206411

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1206436

CABP2
Calcium-binding protein 2

2

16

High-throughput

0.606

High

1206450

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.606

High

1206401

DRC7
Dynein regulatory complex subunit 7

2

0

High-throughput

0.580

High

1206427

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

348868

CLIC3
Chloride intracellular channel protein 3

2

1

High-throughput

0.573

High

169584

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

6

High-throughput

0.553

High

176833

DCLK1
Serine/threonine-protein kinase DCLK1

2

16

High-throughput

0.553

High

322731

RHBT3
Rho-related BTB domain-containing protein 3

2

6

High-throughput

0.553

High

322838

MTCL2
Microtubule cross-linking factor 2

2

4

High-throughput

0.553

High

681827

RBTN2
Rhombotin-2

2

2

High-throughput

0.553

High

933845

GEM
GTP-binding protein GEM

2

4

High-throughput

0.553

High

940989

HDAC4
Histone deacetylase 4

2

2

High-throughput

0.553

High

976900

ERR3
Estrogen-related receptor gamma

2

1

High-throughput

0.553

High

987688

GRB2
Growth factor receptor-bound protein 2

2

1

High-throughput

0.553

High

1042012

LMNB2
Lamin-B2

2

2

High-throughput

0.553

High

1179951

CCD57
Coiled-coil domain-containing protein 57

2

2

High-throughput

0.553

High

1206387

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

3

High-throughput

0.553

High

1206388

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.553

High

1206395

TBCD1
TBC1 domain family member 1

2

8

High-throughput

0.553

High

1206402

CCD13
Coiled-coil domain-containing protein 13

2

2

High-throughput

0.553

High

1206414

GOGA1
Golgin subfamily A member 1

2

2

High-throughput

0.553

High

1206420

CPNE2
Copine-2

2

1

High-throughput

0.553

High

1206422

KCTD7
BTB/POZ domain-containing protein KCTD7

2

1

High-throughput

0.553

High

1206428

CARD9
Caspase recruitment domain-containing protein 9

2

1

High-throughput

0.553

High

1206435

NEK6
Serine/threonine-protein kinase Nek6

2

4

High-throughput

0.553

High

1206440

TB22B
TBC1 domain family member 22B

2

8

High-throughput

0.553

High

1206445

CPNE7
Copine-7

2

1

High-throughput

0.553

High

1206448

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

1

High-throughput

0.553

High

1206449

MYO5B
Unconventional myosin-Vb

2

4

High-throughput

0.553

High

222103

NCK2
Cytoplasmic protein NCK2

1

1

High-throughput

0.523

High

291808

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.523

High

1206400

TRI42
Tripartite motif-containing protein 42

1

4

High-throughput

0.523

High

1206418

JKIP2
Janus kinase and microtubule-interacting protein 2

1

2

High-throughput

0.523

High

1206447

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.523

High

842779

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.494

High

1206391

RBP10
Ran-binding protein 10

1

2

High-throughput

0.489

High

1206394

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.489

High

1206424

RANB9
Ran-binding protein 9

1

2

High-throughput

0.489

High

1206433

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.489

High

1206441

GID8
Glucose-induced degradation protein 8 homolog

1

4

High-throughput

0.489

High

1206412

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

1206434

KIF9
Kinesin-like protein KIF9

1

6

High-throughput

0.481

High

69857

A8K932
Kinesin-like protein

1

6

High-throughput

0.470

High

1194544

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

1206389

Q6P9E2
RECK protein

1

1

High-throughput

0.470

High

1206405

Q8N5D4
Cyclin-G2

1

1

High-throughput

0.470

High

352021

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

1

High-throughput

0.439

High

404116

GCR
Glucocorticoid receptor

1

1

Small-scale

0.439

High

1120853

DGCR6
Protein DGCR6

1

1

High-throughput

0.439

High

1159283

CCNG2
Cyclin-G2

1

1

High-throughput

0.439

High

241901

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.437

High

468464

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

1206451

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

251909

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

6

0

High-throughput

0.386

High

1206419

EDC3
Enhancer of mRNA-decapping protein 3

4

0

High-throughput

0.368

High

1206421

CC120
Coiled-coil domain-containing protein 120

4

0

High-throughput

0.368

High

1085502

ARHG5
Rho guanine nucleotide exchange factor 5

4

0

High-throughput

0.365

High

716153

PBLD
Phenazine biosynthesis-like domain-containing protein

4

0

High-throughput

0.364

High

158228

COPE
Coatomer subunit epsilon

3

0

High-throughput

0.352

High

1165275

LONF1
LON peptidase N-terminal domain and RING finger protein 1

3

0

High-throughput

0.352

High

1206426

SNR25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

3

0

High-throughput

0.352

High

1206442

SPG21
Maspardin

3

0

High-throughput

0.352

High

1206444

NCDN
Neurochondrin

3

0

High-throughput

0.352

High

1055228

MTG8
Protein CBFA2T1

2

0

High-throughput

0.327

High

64456

F221B
Protein FAM221B

2

0

High-throughput

0.316

High

180303

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.316

High

210291

PHF1
PHD finger protein 1

2

0

High-throughput

0.316

High

288432

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

0

High-throughput

0.316

High

568651

GYS1
Glycogen [starch] synthase, muscle

2

0

High-throughput

0.316

High

684267

DDX6
Probable ATP-dependent RNA helicase DDX6

2

0

High-throughput

0.316

High

840916

TXK
Tyrosine-protein kinase TXK

2

0

High-throughput

0.316

High

868183

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.316

High

1028657

U2AF1
Splicing factor U2AF 35 kDa subunit

2

0

High-throughput

0.316

High

1051378

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

High-throughput

0.316

High

1152781

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

2

0

High-throughput

0.316

High

1155964

ZFHX3
Zinc finger homeobox protein 3

2

0

High-throughput

0.316

High

1206390

FXL19
F-box/LRR-repeat protein 19

2

0

High-throughput

0.316

High

1206393

ATOSB
Atos homolog protein B

2

0

High-throughput

0.316

High

1206396

TRI50
E3 ubiquitin-protein ligase TRIM50

2

0

High-throughput

0.316

High

1206398

GLCTK
Glycerate kinase

2

0

High-throughput

0.316

High

1206399

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.316

High

1206403

ZZZ3
ZZ-type zinc finger-containing protein 3

2

0

High-throughput

0.316

High

1206406

IKBD
NF-kappa-B inhibitor delta

2

0

High-throughput

0.316

High

1206407

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

1206408

MIEAP
Mitochondria-eating protein

2

0

High-throughput

0.316

High

1206413

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

0

High-throughput

0.316

High

1206415

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

1206416

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.316

High

1206417

MGN2
Protein mago nashi homolog 2

2

0

High-throughput

0.316

High

1206425

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

1206429

F124B
Protein FAM124B

2

0

High-throughput

0.316

High

1206437

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.316

High

1206438

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

1206439

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

2

0

High-throughput

0.316

High

1206443

RCOR3
REST corepressor 3

2

0

High-throughput

0.316

High

292355

RA51D
DNA repair protein RAD51 homolog 4

1

0

High-throughput

0.299

High

894796

EMD
Emerin

1

0

High-throughput

0.299

High

1206430

ARMC7
Armadillo repeat-containing protein 7

1

0

High-throughput

0.299

High

1206431

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.299

High

1206404

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.292

High

1206446

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.292

High

1206392

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.282

High

977128

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.279

Low

1206397

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.279

Low

1206432

WDR26
WD repeat-containing protein 26

1

0

High-throughput

0.279

Low

352771

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.251

Low

1206410

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.251

Low

622820

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025