Protein: EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)

Gene: EDEM3
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q9BZQ6

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1268005

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

High-throughput

0.618

High

1313599

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

4

Small-scale

0.618

High

1034529

OS9
Protein OS-9

2

4

Small-scale

0.611

High

205944

TGON2
Trans-Golgi network integral membrane protein 2

2

5

Small-scale

0.584

High

1318307

FBX6
F-box only protein 6

2

2

High-throughput

0.584

High

1318318

SE1L1
Protein sel-1 homolog 1

2

4

Small-scale

0.584

High

215853

ANGL7
Angiopoietin-related protein 7

2

4

High-throughput

0.574

High

887066

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.574

High

1240419

TXND5
Thioredoxin domain-containing protein 5

1

9

Small-scale

0.561

High

61713

CDHR4
Cadherin-related family member 4

1

3

High-throughput

0.536

High

172213

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

328237

LGI1
Leucine-rich glioma-inactivated protein 1

1

2

High-throughput

0.536

High

599009

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.536

High

964693

IL5RA
Interleukin-5 receptor subunit alpha

1

3

High-throughput

0.536

High

1109949

SHSL1
Protein shisa-like-1

1

1

High-throughput

0.536

High

1116852

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.536

High

1284436

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

2

High-throughput

0.536

High

1318302

CHST8
Carbohydrate sulfotransferase 8

1

3

High-throughput

0.536

High

1318306

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1318316

DNJB9
DnaJ homolog subfamily B member 9

1

7

High-throughput

0.536

High

1318309

TMPS4
Transmembrane protease serine 4

1

7

High-throughput

0.515

High

789977

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

1251370

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

126647

P2Y10
Putative P2Y purinoceptor 10

1

3

High-throughput

0.489

High

146399

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.489

High

158977

NCTR3
Natural cytotoxicity triggering receptor 3

1

1

High-throughput

0.489

High

474776

CFC1
Cryptic protein

1

1

High-throughput

0.489

High

533064

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.489

High

540339

GPIX
Platelet glycoprotein IX

1

2

High-throughput

0.489

High

685287

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

3

High-throughput

0.489

High

875904

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.489

High

1190780

LYZL2
Lysozyme-like protein 2

1

3

High-throughput

0.489

High

1202729

P2RY8
P2Y purinoceptor 8

1

1

High-throughput

0.489

High

1217173

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.489

High

1240103

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.489

High

1265943

CLC2B
C-type lectin domain family 2 member B

1

4

High-throughput

0.489

High

1271353

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1285503

ESPB1
Epididymal sperm-binding protein 1

1

4

High-throughput

0.489

High

1296621

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

1318303

KLK15
Kallikrein-15

1

6

High-throughput

0.489

High

1318305

LY9
T-lymphocyte surface antigen Ly-9

1

4

High-throughput

0.489

High

1318310

CBLN4
Cerebellin-4

1

1

High-throughput

0.489

High

1318319

BTNL2
Butyrophilin-like protein 2

1

2

High-throughput

0.489

High

1318323

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

266243

ERLN1
Erlin-1

1

3

Small-scale

0.479

High

299981

ERLN2
Erlin-2

1

3

Small-scale

0.479

High

320907

HS74L
Heat shock 70 kDa protein 4L

1

5

Small-scale

0.479

High

344237

A1AT
Alpha-1-antitrypsin

1

1

Small-scale

0.479

High

390506

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

Small-scale

0.479

High

423351

PDIA1
Protein disulfide-isomerase

1

11

Small-scale

0.479

High

502520

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

504710

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

531974

PDIA4
Protein disulfide-isomerase A4

1

10

Small-scale

0.479

High

538390

ENPL
Endoplasmin

1

2

Small-scale

0.479

High

653719

CALR
Calreticulin

1

4

Small-scale

0.479

High

654739

CALX
Calnexin

1

4

Small-scale

0.479

High

670643

ERP29
Endoplasmic reticulum resident protein 29

1

8

Small-scale

0.479

High

671915

PDIA3
Protein disulfide-isomerase A3

1

11

Small-scale

0.479

High

714066

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

763088

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

Small-scale

0.479

High

795267

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.479

High

809965

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

Small-scale

0.479

High

825531

LMAN1
Protein ERGIC-53

1

1

Small-scale

0.479

High

839677

SERPH
Serpin H1

1

2

Small-scale

0.479

High

863545

COPA
Coatomer subunit alpha

1

1

Small-scale

0.479

High

1020546

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

Small-scale

0.479

High

1058535

GANAB
Neutral alpha-glucosidase AB

1

1

Small-scale

0.479

High

1062652

EMC2
ER membrane protein complex subunit 2

1

1

Small-scale

0.479

High

1074304

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1139432

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

Small-scale

0.479

High

1220461

DJC10
DnaJ homolog subfamily C member 10

1

14

Small-scale

0.479

High

1253670

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

4

Small-scale

0.479

High

1267744

HS105
Heat shock protein 105 kDa

1

7

Small-scale

0.479

High

1288814

ERLEC
Endoplasmic reticulum lectin 1

1

4

Small-scale

0.479

High

1310894

ERP44
Endoplasmic reticulum resident protein 44

1

12

Small-scale

0.479

High

1318312

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

2

Small-scale

0.479

High

1318322

HYOU1
Hypoxia up-regulated protein 1

1

6

Small-scale

0.479

High

177996

TMPS2
Transmembrane protease serine 2

1

7

High-throughput

0.470

High

388710

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

391160

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

Small-scale

0.458

High

438852

SRPRA
Signal recognition particle receptor subunit alpha

1

0

Small-scale

0.458

High

500089

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.458

High

536433

GLU2B
Glucosidase 2 subunit beta

1

0

Small-scale

0.458

High

863317

COPB
Coatomer subunit beta

1

0

Small-scale

0.458

High

1045001

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

Small-scale

0.458

High

1086412

MA2A1
Alpha-mannosidase 2

1

0

Small-scale

0.458

High

1236982

EMC1
ER membrane protein complex subunit 1

1

0

Small-scale

0.458

High

1295189

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.458

High

1301210

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

Small-scale

0.458

High

1303922

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.458

High

1318313

HPBP1
Hsp70-binding protein 1

1

0

Small-scale

0.458

High

1318314

EMC3
ER membrane protein complex subunit 3

1

0

Small-scale

0.458

High

883638

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

164475

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

385482

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

607154

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.437

High

725548

COPB2
Coatomer subunit beta'

1

1

Small-scale

0.437

High

1171596

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1217085

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

1299623

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.437

High

1318304

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

1318311

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1318315

SAE1
SUMO-activating enzyme subunit 1

1

1

Small-scale

0.437

High

1318317

SAE2
SUMO-activating enzyme subunit 2

1

1

Small-scale

0.437

High

1318321

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

1318320

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.417

High

2118

TVA20
T cell receptor alpha variable 20

1

1

High-throughput

0.407

High

1316987

LOXE3
Hydroperoxide isomerase ALOXE3

2

0

High-throughput

0.328

High

131958

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

211398

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

614229

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

702291

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

1310308

TM2D3
TM2 domain-containing protein 3

1

0

High-throughput

0.279

Low

878245

SEC13
Protein SEC13 homolog

1

0

Small-scale

0.249

Low

1081897

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.249

Low

1082969

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.249

Low

1318308

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

1301377

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024