Protein: NOP16
Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3)

Gene: NOP16
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q9Y3C1

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0042273 - ribosomal large subunit biogenesis
GO:0043231 - intracellular membrane-bounded organelle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686542

RL13
Large ribosomal subunit protein eL13

2

0

High-throughput

0.748

High

976047

RL7A
Large ribosomal subunit protein eL8

2

0

High-throughput

0.748

High

447611

NPM
Nucleophosmin

3

1

High-throughput

0.667

High

936892

NP1L1
Nucleosome assembly protein 1-like 1

3

1

High-throughput

0.667

High

785552

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.656

High

373576

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

1460426

HERC5
E3 ISG15--protein ligase HERC5

2

1

High-throughput

0.628

High

287204

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

5

High-throughput

0.611

High

1161773

IF16
Gamma-interferon-inducible protein 16

2

2

High-throughput

0.611

High

134192

IPO5
Importin-5

2

0

High-throughput

0.602

High

1275766

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

0

High-throughput

0.602

High

978799

RL23A
Large ribosomal subunit protein uL23

2

0

High-throughput

0.585

High

1409882

RBM4B
RNA-binding protein 4B

2

0

High-throughput

0.585

High

423509

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

1273920

BHA15
Class A basic helix-loop-helix protein 15

2

1

High-throughput

0.574

High

979369

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

1006815

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.550

High

1402649

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.550

High

397289

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

288827

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

476882

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.536

High

522028

H14
Histone H1.4

1

3

High-throughput

0.536

High

595909

H13
Histone H1.3

1

3

High-throughput

0.536

High

659322

SP100
Nuclear autoantigen Sp-100

1

1

High-throughput

0.536

High

833228

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.536

High

993043

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1029411

SET
Protein SET

1

1

High-throughput

0.536

High

1037454

H11
Histone H1.1

1

3

High-throughput

0.536

High

1061223

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.536

High

1062161

SRSF4
Serine/arginine-rich splicing factor 4

1

4

High-throughput

0.536

High

1099317

SRSF5
Serine/arginine-rich splicing factor 5

1

3

High-throughput

0.536

High

1099613

SRSF6
Serine/arginine-rich splicing factor 6

1

4

High-throughput

0.536

High

1151242

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1291302

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1347172

WDR48
WD repeat-containing protein 48

1

2

High-throughput

0.536

High

1351090

DDX54
ATP-dependent RNA helicase DDX54

1

2

High-throughput

0.536

High

1418653

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.536

High

1460394

KLF15
Krueppel-like factor 15

1

6

High-throughput

0.536

High

1490627

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1491169

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.536

High

141180

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

301269

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.513

High

303668

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

429074

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.513

High

479496

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

616063

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

624184

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

809933

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

842605

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

859517

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

860424

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

861031

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

898901

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

905327

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

969534

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

985087

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.513

High

985967

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1016307

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1037701

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1112233

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

1361805

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1364436

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1370487

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1390665

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1410788

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1413428

RBM42
RNA-binding protein 42

1

0

High-throughput

0.513

High

1451840

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

1452017

THUM1
THUMP domain-containing protein 1

1

0

High-throughput

0.513

High

1459783

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1460680

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1461419

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1217853

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.493

High

303000

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.489

High

419283

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.489

High

502602

H2A1
Histone H2A type 1

1

1

High-throughput

0.489

High

1097767

STK3
Serine/threonine-protein kinase 3

1

1

High-throughput

0.489

High

1416968

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.489

High

339905

KLF8
Krueppel-like factor 8

1

6

High-throughput

0.479

High

346542

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

406832

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

596439

H12
Histone H1.2

1

3

High-throughput

0.479

High

965357

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

1008944

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

1036015

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1118702

KLF9
Krueppel-like factor 9

1

5

High-throughput

0.479

High

1118798

KLF5
Krueppel-like factor 5

1

6

High-throughput

0.479

High

1138192

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1146888

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.479

High

1215914

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1231693

RL7L
Ribosomal protein uL30-like

1

1

High-throughput

0.479

High

1235580

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1380278

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1405751

KLF6
Krueppel-like factor 6

1

6

High-throughput

0.479

High

1438102

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1449080

RED2
Double-stranded RNA-specific editase B2

1

2

High-throughput

0.479

High

1491166

KLF12
Krueppel-like factor 12

1

6

High-throughput

0.479

High

129585

MEN1
Menin

1

0

High-throughput

0.458

High

194404

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

218998

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

223441

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

225147

TLX3
T-cell leukemia homeobox protein 3

1

0

High-throughput

0.458

High

254456

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

302678

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

519442

MYB
Transcriptional activator Myb

1

0

High-throughput

0.458

High

607254

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

644148

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

694086

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

699283

CALX
Calnexin

1

0

High-throughput

0.458

High

766967

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

810475

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

872921

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

937992

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

960308

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

980585

H4
Histone H4

1

0

High-throughput

0.458

High

1017322

H33
Histone H3.3

1

0

High-throughput

0.458

High

1029178

E2F1
Transcription factor E2F1

1

0

High-throughput

0.458

High

1096284

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1125270

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

1138797

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1155935

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1271929

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1290849

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1313560

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1330989

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1352856

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1368691

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1385663

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1393858

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1402352

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

1411772

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1416094

REPI1
DNA-binding protein REPIN1

1

0

High-throughput

0.458

High

1421030

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1447482

ANLN
Anillin

1

0

High-throughput

0.458

High

1451477

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1454375

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1459412

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1490821

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.458

High

1490893

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.458

High

1491168

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

766040

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1130547

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

505002

H2AB2
Histone H2A-Bbd type 2/3

1

2

High-throughput

0.437

High

877581

LHX1
LIM/homeobox protein Lhx1

1

1

High-throughput

0.437

High

895824

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.437

High

902156

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.437

High

1037911

HEN1
Helix-loop-helix protein 1

1

1

High-throughput

0.437

High

1233976

Q6ICH2
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.437

High

1308762

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

1

High-throughput

0.437

High

1399212

NP1L5
Nucleosome assembly protein 1-like 5

1

1

High-throughput

0.437

High

442837

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

1411570

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1437427

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

47602

RPSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

73479

B2CML4
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.407

High

1313197

ZC3H3
Zinc finger CCCH domain-containing protein 3

2

0

High-throughput

0.318

High

1060727

SOS2
Son of sevenless homolog 2

2

0

High-throughput

0.298

High

1491165

3BP1
SH3 domain-binding protein 1

2

0

High-throughput

0.298

High

191873

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

288209

CLC3A
C-type lectin domain family 3 member A

1

0

High-throughput

0.279

Low

1127543

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1142224

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1178117

RN151
RING finger protein 151

1

0

High-throughput

0.279

Low

1260465

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

1290062

PNM8A
Paraneoplastic antigen-like protein 8A

1

0

High-throughput

0.279

Low

1356147

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.279

Low

1395744

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1430536

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1349989

CERK1
Ceramide kinase

1

0

High-throughput

0.269

Low

132396

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.249

Low

158021

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

180116

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

401744

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

640339

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

976685

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1133414

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

0

High-throughput

0.249

Low

1141086

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1327289

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1393180

PRR11
Proline-rich protein 11

1

0

High-throughput

0.249

Low

1491167

MAFB
Transcription factor MafB

1

0

High-throughput

0.249

Low

1335791

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1337016

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.232

Low

1387456

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.232

Low

1458415

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025