Protein: MARH3
E3 ubiquitin-protein ligase MARCHF3 (EC 2.3.2.27) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) (RING finger protein 173) (RING-type E3 ubiquitin transferase MARCHF3)

Gene: MARH3, MARCHF3
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q86UD3

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005764 - lysosome
GO:0005768 - endosome
GO:0006897 - endocytosis
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957622

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.606

High

1288116

FATE1
Fetal and adult testis-expressed transcript protein

2

2

High-throughput

0.553

High

909337

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.541

High

957119

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.541

High

982226

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.541

High

1288117

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.541

High

1288119

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.541

High

1288127

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.541

High

422464

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

132134

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

390644

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.479

High

908026

VAMP7
Vesicle-associated membrane protein 7

1

5

High-throughput

0.479

High

957432

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.479

High

987742

GRB2
Growth factor receptor-bound protein 2

1

2

Small-scale

0.479

High

1158673

DPYL2
Dihydropyrimidinase-related protein 2

1

1

High-throughput

0.479

High

1208109

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

2

High-throughput

0.479

High

1288118

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

High-throughput

0.479

High

1288120

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

3

High-throughput

0.479

High

1288121

TM9S2
Transmembrane 9 superfamily member 2

1

1

High-throughput

0.479

High

163321

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

6

High-throughput

0.437

High

275689

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

1

High-throughput

0.437

High

347142

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.437

High

399705

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

2

High-throughput

0.437

High

416754

TYSY
Thymidylate synthase

1

2

High-throughput

0.437

High

467534

4F2
Amino acid transporter heavy chain SLC3A2

1

4

High-throughput

0.437

High

522690

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

7

High-throughput

0.437

High

592856

CBR1
Carbonyl reductase [NADPH] 1

1

3

High-throughput

0.437

High

689950

IL3RA
Interleukin-3 receptor subunit alpha

1

1

Small-scale

0.437

High

1047610

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.437

High

1055330

APLP2
Amyloid beta precursor like protein 2

1

2

High-throughput

0.437

High

1091530

DLG1
Disks large homolog 1

1

1

Small-scale

0.437

High

1288113

LSR
Lipolysis-stimulated lipoprotein receptor

1

2

High-throughput

0.437

High

1288114

ATAD1
Outer mitochondrial transmembrane helix translocase

1

3

High-throughput

0.437

High

1288115

NICA
Nicastrin

1

1

High-throughput

0.437

High

1288122

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

2

High-throughput

0.437

High

1288125

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.437

High

1288126

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.437

High

75514

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.417

High

1288123

APOL2
Apolipoprotein L2

2

0

High-throughput

0.316

High

322038

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.249

Low

551134

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.249

Low

552298

ADT3
ADP/ATP translocase 3

1

0

Small-scale

0.249

Low

609727

LEG3
Galectin-3

1

0

Small-scale

0.249

Low

884151

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.249

Low

915126

CAZA1
F-actin-capping protein subunit alpha-1

1

0

Small-scale

0.249

Low

1089735

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.249

Low

1209964

TM201
Transmembrane protein 201

1

0

High-throughput

0.249

Low

1288124

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.249

Low

1288128

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025