Protein: NICA
Nicastrin

Gene: NICA, NCSTN
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q92542

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002262 - myeloid cell homeostasis
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1364065

PEN2
Gamma-secretase subunit PEN-2

6

3

Small-scale

0.931

High

890024

PSN1
Presenilin-1

12

6

Small-scale

0.755

High

1364051

APH1A
Gamma-secretase subunit APH-1A

10

6

Small-scale

0.751

High

698955

CALX
Calnexin

3

1

High-throughput

0.650

High

890762

PSN2
Presenilin-2

3

6

Small-scale

0.650

High

1232103

VASN
Vasorin

3

0

Small-scale

0.642

High

557408

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.628

High

321318

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

996510

ACTS
Actin, alpha skeletal muscle

2

0

High-throughput

0.602

High

1051818

EF1A2
Elongation factor 1-alpha 2

2

0

High-throughput

0.602

High

1273102

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

2

0

High-throughput

0.602

High

1352041

MICA1
[F-actin]-monooxygenase MICAL1

2

0

High-throughput

0.602

High

774527

BASI
Basigin

2

0

Small-scale

0.598

High

1364062

FBX6
F-box only protein 6

2

1

High-throughput

0.584

High

292184

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.536

High

420638

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.536

High

424979

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.536

High

463180

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.536

High

538647

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

598160

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

659046

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

1

High-throughput

0.536

High

680447

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

902869

BLK
Tyrosine-protein kinase Blk

1

2

High-throughput

0.536

High

1031829

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.536

High

1098929

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.536

High

1363115

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.536

High

1364070

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

1364074

TEST
Testisin

1

1

High-throughput

0.536

High

165630

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

184887

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.513

High

325575

YIF1A
Protein YIF1A

1

0

High-throughput

0.513

High

380646

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

0

High-throughput

0.513

High

402648

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.513

High

518619

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.513

High

520704

RRAS
Ras-related protein R-Ras

1

0

High-throughput

0.513

High

564845

NCAM1
Neural cell adhesion molecule 1

1

0

High-throughput

0.513

High

710400

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.513

High

733030

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.513

High

1010085

DLK1
Protein delta homolog 1

1

0

High-throughput

0.513

High

1142903

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.513

High

1164492

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.513

High

1214887

WLS
Protein wntless homolog

1

0

High-throughput

0.513

High

1279040

TAFA1
Chemokine-like protein TAFA-1

1

0

High-throughput

0.513

High

1308645

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

1326203

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.513

High

1364053

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.513

High

1364054

F111A
Serine protease FAM111A

1

0

High-throughput

0.513

High

1364055

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1364059

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

1364064

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.513

High

1364071

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.513

High

1364073

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.513

High

1364075

KC1G3
Casein kinase I isoform gamma-3

1

0

High-throughput

0.513

High

888945

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

Small-scale

0.500

High

1151030

PCH2
Pachytene checkpoint protein 2 homolog

1

1

High-throughput

0.489

High

853837

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.480

High

942349

BACE1
Beta-secretase 1

1

0

Small-scale

0.480

High

591205

ANPRA
Atrial natriuretic peptide receptor 1

1

0

Small-scale

0.479

High

1120636

DAG1
Dystroglycan 1

1

0

Small-scale

0.479

High

1120782

DSG2
Desmoglein-2

1

0

Small-scale

0.479

High

1249625

PXDC2
Plexin domain-containing protein 2

1

0

Small-scale

0.479

High

1339500

DNER
Delta and Notch-like epidermal growth factor-related receptor

1

0

Small-scale

0.479

High

48723

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

412350

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

464022

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.479

High

609762

LEG3
Galectin-3

1

1

Small-scale

0.479

High

1163790

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

High-throughput

0.479

High

1286849

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.479

High

1308174

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1334491

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1359067

APH1B
Gamma-secretase subunit APH-1B

1

6

Small-scale

0.479

High

1364052

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.479

High

1364066

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.479

High

522283

OSTP
Osteopontin

1

0

Small-scale

0.460

High

178348

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

218558

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

422750

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

583098

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

907511

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

1033096

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1113869

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1249064

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1252158

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1291098

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

Small-scale

0.458

High

1364050

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1364063

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

116442

H7BXI1
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

538849

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

2

Small-scale

0.445

High

800543

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.445

High

1348030

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

2

High-throughput

0.445

High

1364072

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

61867

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

125548

LEG9
Galectin-9

1

1

High-throughput

0.437

High

1288115

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

1

High-throughput

0.437

High

607311

NEUM
Neuromodulin

1

0

Small-scale

0.426

High

948896

CD81
CD81 antigen

1

0

High-throughput

0.426

High

963450

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.426

High

1124875

FLOT2
Flotillin-2

1

0

Small-scale

0.426

High

1196208

S22A6
Solute carrier family 22 member 6

1

0

High-throughput

0.426

High

1243640

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.426

High

1289161

OSTB
Organic solute transporter subunit beta

1

0

High-throughput

0.426

High

488255

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.328

High

106368

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

137339

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.279

Low

208073

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.279

Low

223638

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

1005754

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.279

Low

1147649

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.279

Low

1238758

TECT3
Tectonic-3

1

0

High-throughput

0.279

Low

1272947

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.279

Low

1364056

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.279

Low

1364057

CRNL1
Crooked neck-like protein 1

1

0

High-throughput

0.279

Low

1364058

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.279

Low

1364060

CA198
Uncharacterized protein C1orf198

1

0

High-throughput

0.279

Low

1364061

SFXN1
Sideroflexin-1

1

0

High-throughput

0.279

Low

1364069

TRM6
tRNA

1

0

High-throughput

0.279

Low

1364076

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

294104

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

589285

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696074

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

831147

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1004904

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1106633

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

1197655

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1254860

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1271759

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1364067

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1364068

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.249

Low

1227171

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025