Protein: MVP
Major vault protein (MVP) (Lung resistance-related protein)

Gene: MVP
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q14764

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005643 - nuclear pore
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1131946

MVP
Major vault protein

5

1

High-throughput

0.928

High

1132013

PARP4
Protein mono-ADP-ribosyltransferase PARP4

4

0

Small-scale

0.670

High

1131978

COP1
E3 ubiquitin-protein ligase COP1

3

1

Small-scale

0.667

High

1132008

RCOR3
REST corepressor 3

3

1

High-throughput

0.662

High

1132001

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

0

High-throughput

0.634

High

1132015

DD19B
ATP-dependent RNA helicase DDX19B

2

0

High-throughput

0.585

High

180516

PLS1
Phospholipid scramblase 1

2

1

High-throughput

0.584

High

1131952

NRF1
Nuclear respiratory factor 1

2

0

High-throughput

0.580

High

1131955

FND3B
Fibronectin type III domain-containing protein 3B

2

0

High-throughput

0.580

High

1131969

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1131980

UBTD2
Ubiquitin domain-containing protein 2

2

0

High-throughput

0.580

High

1131987

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1131996

TOLIP
Toll-interacting protein

2

0

High-throughput

0.580

High

563774

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

396124

ESR1
Estrogen receptor

1

1

Small-scale

0.561

High

1132003

ANLN
Anillin

2

0

High-throughput

0.559

High

951676

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.549

High

249752

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

631223

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

876681

HSP13
Heat shock 70 kDa protein 13

1

1

High-throughput

0.541

High

899907

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.541

High

900331

FXR2
RNA-binding protein FXR2

1

2

High-throughput

0.541

High

1056730

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.541

High

668780

CO8A2
Collagen alpha-2(VIII) chain

1

1

High-throughput

0.536

High

1063766

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.536

High

1124450

MAP7
Ensconsin

1

2

High-throughput

0.536

High

943353

H2BFS
Histone H2B type F-S

1

4

High-throughput

0.515

High

946778

H2B1D
Histone H2B type 1-D

1

4

High-throughput

0.515

High

1131954

H2B2E
Histone H2B type 2-E

1

4

High-throughput

0.515

High

1131957

H2B2F
Histone H2B type 2-F

1

4

High-throughput

0.515

High

1131984

H2B1H
Histone H2B type 1-H

1

4

High-throughput

0.515

High

537172

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

602789

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

611123

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.513

High

642551

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

907273

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.513

High

943053

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1023781

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1026035

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1110978

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1115657

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1131989

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1132007

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

1124804

FLOT2
Flotillin-2

1

0

High-throughput

0.493

High

138686

IMA4
Importin subunit alpha-4

1

2

High-throughput

0.481

High

220770

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

High-throughput

0.481

High

326858

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

4

High-throughput

0.481

High

413842

P53
Cellular tumor antigen p53

1

1

High-throughput

0.481

High

555483

SKIL
Ski-like protein

1

2

High-throughput

0.481

High

571977

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.481

High

587084

ITF2
Transcription factor 4

1

1

High-throughput

0.481

High

893692

MEOX1
Homeobox protein MOX-1

1

7

High-throughput

0.481

High

893865

MEOX2
Homeobox protein MOX-2

1

7

High-throughput

0.481

High

910898

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.481

High

1048855

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.481

High

1058418

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.481

High

1060015

DLX2
Homeobox protein DLX-2

1

1

High-throughput

0.481

High

1061696

TLE5
TLE family member 5

1

2

High-throughput

0.481

High

1063252

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.481

High

1065926

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.481

High

1086218

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.481

High

1090646

TRAF2
TNF receptor-associated factor 2

1

4

High-throughput

0.481

High

1095633

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

5

High-throughput

0.481

High

1110243

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

1

High-throughput

0.481

High

1131949

PCH2
Pachytene checkpoint protein 2 homolog

1

2

High-throughput

0.481

High

1131950

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.481

High

1131958

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.481

High

1131964

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.481

High

1131968

NT2NA
Notch homolog 2 N-terminal-like protein A

1

1

High-throughput

0.481

High

1131972

SAXO1
Stabilizer of axonemal microtubules 1

1

1

High-throughput

0.481

High

1131975

BANP
Protein BANP

1

1

High-throughput

0.481

High

1131976

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

1

High-throughput

0.481

High

1131982

PIHD2
PIH1 domain-containing protein 2

1

1

High-throughput

0.481

High

1131983

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.481

High

1131986

MRTFA
Myocardin-related transcription factor A

1

1

High-throughput

0.481

High

1131988

RAB3I
Rab-3A-interacting protein

1

1

High-throughput

0.481

High

1131991

MDFI
MyoD family inhibitor

1

2

High-throughput

0.481

High

1131993

RHXF2
Rhox homeobox family member 2

1

1

High-throughput

0.481

High

1131999

STN1
CST complex subunit STN1

1

1

High-throughput

0.481

High

1132005

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.481

High

1132009

RIM3A
RIMS-binding protein 3A

1

3

High-throughput

0.481

High

1132010

SRTD1
SERTA domain-containing protein 1

1

1

High-throughput

0.481

High

1132011

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

6

High-throughput

0.481

High

1132017

ZBT32
Zinc finger and BTB domain-containing protein 32

1

2

High-throughput

0.481

High

507980

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

138112

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

187968

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

Small-scale

0.479

High

323376

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

555393

SKI
Ski oncogene

1

2

Small-scale

0.479

High

574094

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.479

High

799119

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

1047906

TLE2
Transducin-like enhancer protein 2

1

2

High-throughput

0.479

High

1098348

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.479

High

1131947

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1131966

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1131992

TEP1
Telomerase protein component 1

1

1

Small-scale

0.479

High

1132018

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

1132019

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.479

High

357857

CYB
Cytochrome b

1

0

High-throughput

0.460

High

366174

HPT
Haptoglobin

1

0

High-throughput

0.460

High

761178

HYES
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2

1

0

High-throughput

0.460

High

1104717

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.460

High

1131965

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.460

High

129086

MEN1
Menin

1

0

High-throughput

0.458

High

132042

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

135214

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.458

High

170140

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

248873

GSDME
Gasdermin-E

1

0

Small-scale

0.458

High

251582

CCNT1
Cyclin-T1

1

0

High-throughput

0.458

High

349081

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

372044

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

378093

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

482479

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

613038

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

651330

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

685563

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

767211

MERL
Merlin

1

0

High-throughput

0.458

High

772806

MYH9
Myosin-9

1

0

High-throughput

0.458

High

851766

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

888070

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

891556

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

904722

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

979661

H4
Histone H4

1

0

High-throughput

0.458

High

990230

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

1022716

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

Small-scale

0.458

High

1035620

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1131948

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1131951

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1131953

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

1131956

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

1131959

CD276
CD276 antigen

1

0

Small-scale

0.458

High

1131963

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1131973

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1131974

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1131979

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1131981

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1131985

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1131994

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1131995

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1131997

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1131998

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.458

High

1132000

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1132002

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1132004

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1132012

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

1131960

Q6FHY5
MEOX2 protein

1

7

High-throughput

0.457

High

1131961

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

1131990

ZBT18
Zinc finger and BTB domain-containing protein 18

1

1

High-throughput

0.445

High

1132014

RCOR1
REST corepressor 1

1

1

High-throughput

0.445

High

1131962

CA094
Uncharacterized protein C1orf94

1

1

High-throughput

0.439

High

1131967

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.439

High

1131970

TRI42
Tripartite motif-containing protein 42

1

6

High-throughput

0.439

High

1131971

IHO1
Interactor of HORMAD1 protein 1

1

1

High-throughput

0.439

High

384155

CO1A1
Collagen alpha-1(I) chain

1

0

Small-scale

0.426

High

765520

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

967733

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

1103170

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

1119127

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1121666

SAFB2
Scaffold attachment factor B2

1

0

High-throughput

0.426

High

1131977

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.426

High

255025

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

1132016

COLQ
Acetylcholinesterase collagenic tail peptide

1

0

High-throughput

0.279

Low

1122389

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.251

Low

1132006

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.251

Low

105941

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

653317

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025