Protein: HS12A
Heat shock 70 kDa protein 12A (Heat shock protein family A member 12A)

Gene: HS12A, HSPA12A
Organism: Homo sapiens
Interactions: 110
UniProt ID: O43301

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212988

HS12B
Heat shock 70 kDa protein 12B

5

0

High-throughput

0.683

High

212948

AKA12
A-kinase anchor protein 12

3

1

High-throughput

0.671

High

212969

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

3

2

High-throughput

0.667

High

141883

PODXL
Podocalyxin

3

1

High-throughput

0.662

High

213007

E41L3
Band 4.1-like protein 3

4

1

High-throughput

0.641

High

212923

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.628

High

212927

LAMP2
Lysosome-associated membrane glycoprotein 2

2

2

High-throughput

0.628

High

212937

BASI
Basigin

2

3

High-throughput

0.611

High

212991

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

2

High-throughput

0.611

High

212919

TNFA
Tumor necrosis factor

2

0

High-throughput

0.585

High

212978

RBCC1
RB1-inducible coiled-coil protein 1

2

0

High-throughput

0.585

High

212951

NAR3
Ecto-ADP-ribosyltransferase 3

2

1

High-throughput

0.584

High

212976

F174A
Membrane protein FAM174A

2

1

High-throughput

0.574

High

213005

LAMP3
Lysosome-associated membrane glycoprotein 3

2

2

High-throughput

0.574

High

213009

NPTN
Neuroplastin

2

3

High-throughput

0.549

High

174202

ARHGA
Rho guanine nucleotide exchange factor 10

1

1

High-throughput

0.536

High

212916

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.536

High

212922

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.536

High

212956

PKHG4
Puratrophin-1

1

1

High-throughput

0.536

High

212960

NFXL1
NF-X1-type zinc finger protein NFXL1

1

1

High-throughput

0.536

High

212971

PHAR4
Phosphatase and actin regulator 4

1

1

High-throughput

0.536

High

212981

PALLD
Palladin

1

1

High-throughput

0.536

High

212999

RHG35
Rho GTPase-activating protein 35

1

1

High-throughput

0.536

High

212982

SORL
Sortilin-related receptor

1

0

Small-scale

0.529

High

142190

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.513

High

177740

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

0

High-throughput

0.513

High

212928

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

High-throughput

0.513

High

212929

LFA3
Lymphocyte function-associated antigen 3

1

0

High-throughput

0.513

High

212947

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

212950

CSN1
COP9 signalosome complex subunit 1

1

0

High-throughput

0.513

High

212952

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

212954

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

High-throughput

0.513

High

212955

SYUB
Beta-synuclein

1

0

High-throughput

0.513

High

212959

BCOR
BCL-6 corepressor

1

0

High-throughput

0.513

High

212963

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.513

High

212967

LONP2
Lon protease homolog 2, peroxisomal

1

0

High-throughput

0.513

High

212974

NCOA7
Nuclear receptor coactivator 7

1

0

High-throughput

0.513

High

212980

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.513

High

212983

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.513

High

212990

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

212996

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.513

High

212998

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.513

High

213004

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.513

High

51774

MACD2
ADP-ribose glycohydrolase MACROD2

1

0

High-throughput

0.493

High

212972

KT222
Keratin-like protein KRT222

1

3

High-throughput

0.489

High

212973

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

1

High-throughput

0.489

High

212992

AP5M1
AP-5 complex subunit mu-1

1

1

High-throughput

0.489

High

213003

ICAM5
Intercellular adhesion molecule 5

1

2

High-throughput

0.489

High

213008

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

212918

RASH
GTPase HRas

1

0

Small-scale

0.480

High

123945

SNP23
Synaptosomal-associated protein 23

1

1

High-throughput

0.479

High

212917

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

212925

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

212926

FGFR1
Fibroblast growth factor receptor 1

1

3

High-throughput

0.479

High

212931

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.479

High

212935

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.479

High

212941

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

212943

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.479

High

212944

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.479

High

212945

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

212946

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

3

High-throughput

0.479

High

212949

DLG1
Disks large homolog 1

1

1

High-throughput

0.479

High

212953

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

3

High-throughput

0.479

High

212961

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

212997

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.479

High

212984

NRCAM
Neuronal cell adhesion molecule

1

1

Small-scale

0.464

High

141214

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

181667

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.458

High

212913

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

212914

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

212915

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

212932

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

0

High-throughput

0.458

High

212933

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

212934

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

212938

ICLN
Methylosome subunit pICln

1

0

High-throughput

0.458

High

212939

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.458

High

212958

ELP2
Elongator complex protein 2

1

0

High-throughput

0.458

High

212964

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

212994

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

126381

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.437

High

212962

RHOU
Rho-related GTP-binding protein RhoU

1

3

High-throughput

0.437

High

212975

VANG1
Vang-like protein 1

1

1

High-throughput

0.437

High

212924

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

0

High-throughput

0.426

High

212940

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

213006

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

212957

Q5J1K9
Mono-ADP-ribosyltransferase 3 variant Ia

1

1

High-throughput

0.407

High

212989

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.407

High

213000

TMM51
Transmembrane protein 51

3

0

High-throughput

0.347

High

213002

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

212912

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.318

High

212986

WBP1
WW domain-binding protein 1

2

0

High-throughput

0.318

High

212936

CD80
T-lymphocyte activation antigen CD80

2

0

High-throughput

0.313

High

166814

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low

212970

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.279

Low

212977

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

212979

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

213001

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

212930

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

Small-scale

0.265

Low

104883

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

139770

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

212965

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

Small-scale

0.249

Low

212968

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

212993

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.249

Low

212987

MEG10
Multiple epidermal growth factor-like domains protein 10

1

0

Small-scale

0.238

Low

212920

C1QC
Complement C1q subcomponent subunit C

1

0

High-throughput

0.232

Low

212921

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.232

Low

212942

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.232

Low

212966

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.232

Low

212985

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.232

Low

212995

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025