Protein: NIPS2
Protein NipSnap homolog 2 (NipSnap2) (Glioblastoma-amplified sequence)

Gene: NIPS2, NIPSNAP2
Organism: Homo sapiens
Interactions: 201
UniProt ID: O75323

Gene Ontology (top 5):
GO:0000423 - mitophagy
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005759 - mitochondrial matrix
GO:0006119 - oxidative phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276167

NIPS1
Protein NipSnap homolog 1

6

5

High-throughput

0.943

High

276123

SQSTM
Sequestosome-1

4

4

Small-scale

0.686

High

276047

CH60
60 kDa heat shock protein, mitochondrial

3

5

High-throughput

0.667

High

276116

KPCZ
Protein kinase C zeta type

5

3

High-throughput

0.654

High

276025

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

10

Small-scale

0.639

High

276096

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

10

High-throughput

0.639

High

276173

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

10

High-throughput

0.639

High

276139

KLH22
Kelch-like protein 22

4

2

High-throughput

0.627

High

276075

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

1

Small-scale

0.611

High

276176

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

10

Small-scale

0.611

High

276124

CUL3
Cullin-3

3

1

High-throughput

0.599

High

276076

KPCI
Protein kinase C iota type

3

3

High-throughput

0.593

High

276174

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

10

High-throughput

0.586

High

276042

PARP1
Poly [ADP-ribose] polymerase 1

2

0

High-throughput

0.585

High

276032

NTRK1
High affinity nerve growth factor receptor

2

2

Small-scale

0.584

High

276136

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

276159

ESR2
Estrogen receptor beta

2

1

Small-scale

0.584

High

276017

NIPS2
Protein NipSnap homolog 2

1

5

High-throughput

0.575

High

276064

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

2

High-throughput

0.536

High

276077

CACP
Carnitine O-acetyltransferase

1

3

High-throughput

0.536

High

276181

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

2

High-throughput

0.536

High

276130

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

2

Small-scale

0.533

High

276171

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

10

High-throughput

0.527

High

276149

PPR3B
Protein phosphatase 1 regulatory subunit 3B

2

1

High-throughput

0.521

High

219672

FOXO3
Forkhead box protein O3

1

0

High-throughput

0.513

High

276026

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.513

High

276040

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.513

High

276057

HXK1
Hexokinase-1

1

0

High-throughput

0.513

High

276114

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.513

High

276044

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

276049

CADH1
Cadherin-1

1

1

Small-scale

0.489

High

276126

KEAP1
Kelch-like ECH-associated protein 1

1

2

High-throughput

0.489

High

276129

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.489

High

276143

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.489

High

276190

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.489

High

61372

VWA8
von Willebrand factor A domain-containing protein 8

1

2

High-throughput

0.479

High

137579

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

141229

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

274945

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

276024

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

276036

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

Small-scale

0.479

High

276062

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

Small-scale

0.479

High

276063

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

Small-scale

0.479

High

276070

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

276074

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

276083

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

3

Small-scale

0.479

High

276094

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

Small-scale

0.479

High

276115

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

276122

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

Small-scale

0.479

High

276134

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

276142

ATD3B
ATPase family AAA domain-containing protein 3B

1

2

Small-scale

0.479

High

276147

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

276161

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.479

High

276183

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

High-throughput

0.479

High

276197

SAM50
Sorting and assembly machinery component 50 homolog

1

1

Small-scale

0.479

High

104945

APRIO
Alternative prion protein

1

0

Small-scale

0.460

High

271381

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

276027

CATA
Catalase

1

0

Small-scale

0.458

High

276035

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

276068

ABCD3
ATP-binding cassette sub-family D member 3

1

0

Small-scale

0.458

High

276071

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

276080

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

276099

ABCE1
ATP-binding cassette sub-family E member 1

1

0

Small-scale

0.458

High

276135

FSCN1
Fascin

1

0

Small-scale

0.458

High

276144

CAVN1
Caveolae-associated protein 1

1

0

Small-scale

0.458

High

276153

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

276172

TRIM5
Tripartite motif-containing protein 5

1

0

Small-scale

0.458

High

276175

EHD4
EH domain-containing protein 4

1

0

Small-scale

0.458

High

276184

MIC19
MICOS complex subunit MIC19

1

0

Small-scale

0.458

High

276194

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

Small-scale

0.458

High

276059

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.457

High

858

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

276046

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

276141

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

123017

DX39A
ATP-dependent RNA helicase DDX39A

1

3

High-throughput

0.437

High

164197

NRP1
Neuropilin-1

1

1

High-throughput

0.437

High

172327

XPO1
Exportin-1

1

1

High-throughput

0.437

High

207379

DHX15
ATP-dependent RNA helicase DHX15

1

1

Small-scale

0.437

High

276018

FLNB
Filamin-B

1

1

Small-scale

0.437

High

276020

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

Small-scale

0.437

High

276023

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.437

High

276029

ANXA1
Annexin A1

1

2

Small-scale

0.437

High

276038

ANXA2
Annexin A2

1

2

Small-scale

0.437

High

276039

ANXA5
Annexin A5

1

2

Small-scale

0.437

High

276041

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.437

High

276050

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

276051

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

Small-scale

0.437

High

276052

DESP
Desmoplakin

1

1

Small-scale

0.437

High

276053

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

276055

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.437

High

276056

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

Small-scale

0.437

High

276060

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.437

High

276065

EF1G
Elongation factor 1-gamma

1

1

Small-scale

0.437

High

276066

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

276067

PYR1
Multifunctional protein CAD

1

2

Small-scale

0.437

High

276069

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

276073

TCPZ
T-complex protein 1 subunit zeta

1

7

Small-scale

0.437

High

276079

TCPE
T-complex protein 1 subunit epsilon

1

7

Small-scale

0.437

High

276082

TCPG
T-complex protein 1 subunit gamma

1

7

Small-scale

0.437

High

276086

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

2

Small-scale

0.437

High

276091

COPA
Coatomer subunit alpha

1

1

Small-scale

0.437

High

276093

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.437

High

276097

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.437

High

276098

IF4A1
Eukaryotic initiation factor 4A-I

1

2

Small-scale

0.437

High

276101

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

Small-scale

0.437

High

276102

ACTG
Actin, cytoplasmic 2

1

1

Small-scale

0.437

High

276105

TCPB
T-complex protein 1 subunit beta

1

8

Small-scale

0.437

High

276112

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

276118

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.437

High

276120

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

Small-scale

0.437

High

276125

DX39B
Spliceosome RNA helicase DDX39B

1

4

Small-scale

0.437

High

276128

NBR1
Next to BRCA1 gene 1 protein

1

1

Small-scale

0.437

High

276131

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.437

High

276137

AMOT
Angiomotin

1

1

High-throughput

0.437

High

276146

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

276155

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

276156

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

276160

DDX17
Probable ATP-dependent RNA helicase DDX17

1

2

Small-scale

0.437

High

276163

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

Small-scale

0.437

High

276164

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.437

High

276166

TCPH
T-complex protein 1 subunit eta

1

7

Small-scale

0.437

High

276177

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.437

High

276178

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

276179

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

276180

PKHA1
Pleckstrin homology domain-containing family A member 1

1

1

Small-scale

0.437

High

276182

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.437

High

276192

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

276019

ULK1
Serine/threonine-protein kinase ULK1

1

0

High-throughput

0.426

High

276170

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.407

High

276151

DCP2
m7GpppN-mRNA hydrolase

2

0

High-throughput

0.318

High

213299

ADCY6
Adenylate cyclase type 6

2

0

High-throughput

0.305

High

276048

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.282

High

176628

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.279

Low

276021

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.279

Low

276030

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.279

Low

276054

CD44
CD44 antigen

1

0

High-throughput

0.279

Low

276095

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.279

Low

276107

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.279

Low

276113

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.279

Low

276168

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.279

Low

276169

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.279

Low

276191

ANFY1
Rabankyrin-5

1

0

High-throughput

0.279

Low

276193

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.279

Low

276196

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.279

Low

276157

PYRD1
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1

1

0

High-throughput

0.269

Low

246336

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.261

Low

131254

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.249

Low

178117

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

224560

ACTN4
Alpha-actinin-4

1

0

Small-scale

0.249

Low

276022

ERLN2
Erlin-2

1

0

Small-scale

0.249

Low

276028

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.249

Low

276031

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

Small-scale

0.249

Low

276033

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

Small-scale

0.249

Low

276037

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

276043

H2A1
Histone H2A type 1

1

0

Small-scale

0.249

Low

276045

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

Small-scale

0.249

Low

276058

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

276061

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

276072

TACT
T-cell surface protein tactile

1

0

High-throughput

0.249

Low

276078

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.249

Low

276081

FAS
Fatty acid synthase

1

0

Small-scale

0.249

Low

276084

DYN2
Dynamin-2

1

0

Small-scale

0.249

Low

276085

FXR2
RNA-binding protein FXR2

1

0

Small-scale

0.249

Low

276087

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.249

Low

276088

EFNA4
Ephrin-A4

1

0

High-throughput

0.249

Low

276089

CRIP2
Cysteine-rich protein 2

1

0

Small-scale

0.249

Low

276090

ACLY
ATP-citrate synthase

1

0

Small-scale

0.249

Low

276092

ICLN
Methylosome subunit pICln

1

0

Small-scale

0.249

Low

276100

H4
Histone H4

1

0

Small-scale

0.249

Low

276103

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.249

Low

276104

HBB
Hemoglobin subunit beta

1

0

Small-scale

0.249

Low

276106

GSTO1
Glutathione S-transferase omega-1

1

0

Small-scale

0.249

Low

276108

ERH
Enhancer of rudimentary homolog

1

0

Small-scale

0.249

Low

276109

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.249

Low

276110

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

276111

CAP1
Adenylyl cyclase-associated protein 1

1

0

Small-scale

0.249

Low

276117

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

Small-scale

0.249

Low

276119

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.249

Low

276121

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

Small-scale

0.249

Low

276127

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.249

Low

276132

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.249

Low

276133

CYTM
Cystatin-M

1

0

Small-scale

0.249

Low

276138

FA98B
Protein FAM98B

1

0

Small-scale

0.249

Low

276140

FILA2
Filaggrin-2

1

0

Small-scale

0.249

Low

276145

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

Small-scale

0.249

Low

276148

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

276158

GCN1
Stalled ribosome sensor GCN1

1

0

Small-scale

0.249

Low

276162

AP2M1
AP-2 complex subunit mu

1

0

Small-scale

0.249

Low

276185

AATF
Protein AATF

1

0

High-throughput

0.249

Low

276186

BCLF1
Bcl-2-associated transcription factor 1

1

0

Small-scale

0.249

Low

276187

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

Small-scale

0.249

Low

276188

HACD3
Very-long-chain

1

0

Small-scale

0.249

Low

276189

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

0

Small-scale

0.249

Low

276195

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

Small-scale

0.249

Low

254677

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

276034

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

276150

S13A5
Na(+)/citrate cotransporter

1

0

High-throughput

0.232

Low

276152

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.232

Low

276154

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

276165

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025