Protein: SC6A1
Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)

Gene: SC6A1, SLC6A1
Organism: Homo sapiens
Interactions: 38
UniProt ID: P30531

Gene Ontology (top 5):
GO:0005332 - gamma-aminobutyric acid:sodium:chloride symporter activity
GO:0005886 - plasma membrane
GO:0006865 - amino acid transport
GO:0007268 - chemical synaptic transmission
GO:0007613 - memory

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720390

STX1A
Syntaxin-1A

3

15

Small-scale

0.667

High

720400

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.578

High

379422

IGHG3
Immunoglobulin heavy constant gamma 3

1

2

High-throughput

0.575

High

572414

DRD2
D(2) dopamine receptor

1

3

High-throughput

0.541

High

720384

5HT6R
5-hydroxytryptamine receptor 6

1

1

High-throughput

0.541

High

387702

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

4

High-throughput

0.536

High

387795

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

4

High-throughput

0.536

High

387950

FIBG
Fibrinogen gamma chain

1

4

High-throughput

0.536

High

720396

AT11C
Phospholipid-transporting ATPase IG

1

6

High-throughput

0.536

High

366334

PLMN
Plasminogen

1

0

High-throughput

0.513

High

720386

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

5

High-throughput

0.494

High

282566

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

4

High-throughput

0.489

High

720388

TRI29
Tripartite motif-containing protein 29

1

1

High-throughput

0.489

High

720399

5NT3A
Cytosolic 5'-nucleotidase 3A

1

3

High-throughput

0.489

High

720401

TM242
Transmembrane protein 242

1

1

High-throughput

0.489

High

720381

SYUA
Alpha-synuclein

1

10

High-throughput

0.481

High

720383

T4S4
Transmembrane 4 L6 family member 4

1

0

Small-scale

0.458

High

720395

VA0D2
V-type proton ATPase subunit d 2

1

0

High-throughput

0.458

High

720394

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

1

Small-scale

0.457

High

467236

MDR1
ATP-dependent translocase ABCB1

1

3

High-throughput

0.445

High

665526

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

2

High-throughput

0.445

High

698418

CALX
Calnexin

1

17

High-throughput

0.445

High

720380

SC5A2
Sodium/glucose cotransporter 2

1

2

High-throughput

0.445

High

720382

HD
Huntingtin

1

2

High-throughput

0.445

High

720387

KDSR
3-ketodihydrosphingosine reductase

1

10

High-throughput

0.445

High

720389

FLOT2
Flotillin-2

1

8

High-throughput

0.445

High

720391

SC5A9
Sodium/glucose cotransporter 4

1

2

High-throughput

0.445

High

720397

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

4

High-throughput

0.445

High

720398

SGMR1
Sigma non-opioid intracellular receptor 1

1

3

High-throughput

0.445

High

720402

NPTN
Neuroplastin

1

3

High-throughput

0.445

High

105420

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

213307

ADCY6
Adenylate cyclase type 6

1

0

High-throughput

0.426

High

720385

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.426

High

170672

CLGN
Calmegin

1

17

High-throughput

0.407

High

720393

RABL3
Rab-like protein 3

1

13

High-throughput

0.407

High

269150

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

399548

VTNC
Vitronectin

1

0

High-throughput

0.279

Low

720392

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025