Protein: KDSR
3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1)

Gene: KDSR
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q06136

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006666 - 3-keto-sphinganine metabolic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1053837

SG196
Protein O-mannose kinase

3

2

High-throughput

0.667

High

1026982

REEP5
Receptor expression-enhancing protein 5

2

7

High-throughput

0.628

High

1053799

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

17

High-throughput

0.618

High

256021

S19A2
Thiamine transporter 1

2

1

High-throughput

0.601

High

1053814

S35F2
Solute carrier family 35 member F2

2

4

High-throughput

0.601

High

443762

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

0

High-throughput

0.576

High

869586

SC6A8
Sodium- and chloride-dependent creatine transporter 1

2

10

Small-scale

0.571

High

252675

TSN3
Tetraspanin-3

2

10

High-throughput

0.558

High

622048

CD53
Leukocyte surface antigen CD53

2

11

High-throughput

0.549

High

1053817

MFSD8
Major facilitator superfamily domain-containing protein 8

2

4

High-throughput

0.549

High

190603

MRP4
ATP-binding cassette sub-family C member 4

1

3

High-throughput

0.536

High

230784

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

252593

TSN2
Tetraspanin-2

1

10

High-throughput

0.536

High

325542

YIF1A
Protein YIF1A

1

2

High-throughput

0.536

High

328903

RTN3
Reticulon-3

1

12

High-throughput

0.536

High

477414

CD63
CD63 antigen

1

11

High-throughput

0.536

High

665573

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.536

High

687101

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

1

High-throughput

0.536

High

692191

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

1

High-throughput

0.536

High

701406

5HT1B
5-hydroxytryptamine receptor 1B

1

5

High-throughput

0.536

High

762121

CNR2
Cannabinoid receptor 2

1

14

Small-scale

0.536

High

773483

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.536

High

800286

INGR2
Interferon gamma receptor 2

1

2

High-throughput

0.536

High

1053796

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

2

High-throughput

0.536

High

1053801

YIF1B
Protein YIF1B

1

2

High-throughput

0.536

High

1053807

CERS6
Ceramide synthase 6

1

3

High-throughput

0.536

High

1053818

GOGA5
Golgin subfamily A member 5

1

1

High-throughput

0.536

High

1053821

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

1

High-throughput

0.536

High

1053823

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.536

High

1053825

CERS2
Ceramide synthase 2

1

3

High-throughput

0.536

High

1053826

REEP6
Receptor expression-enhancing protein 6

1

7

High-throughput

0.536

High

1053831

TACAN
Transmembrane protein 120A

1

4

High-throughput

0.536

High

1053845

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

2

High-throughput

0.536

High

1053846

PRAF1
Prenylated Rab acceptor protein 1

1

3

High-throughput

0.536

High

1053849

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.536

High

301406

WFS1
Wolframin

1

1

High-throughput

0.515

High

357856

CYB
Cytochrome b

1

0

High-throughput

0.513

High

536251

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

616172

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.513

High

784591

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

1053798

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.513

High

1053800

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.513

High

1053827

SGCZ
Zeta-sarcoglycan

1

0

High-throughput

0.513

High

1053828

TLCD4
TLC domain-containing protein 4

1

0

High-throughput

0.513

High

1053833

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.513

High

1053836

XYLT2
Xylosyltransferase 2

1

0

High-throughput

0.513

High

1053840

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

1053848

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.513

High

507866

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

1053797

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.494

High

389816

TTHY
Transthyretin

1

0

High-throughput

0.493

High

415521

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

125735

STXB3
Syntaxin-binding protein 3

1

3

High-throughput

0.489

High

222366

TSN6
Tetraspanin-6

1

10

High-throughput

0.489

High

260857

RAMP3
Receptor activity-modifying protein 3

1

3

High-throughput

0.489

High

349408

TSN15
Tetraspanin-15

1

11

High-throughput

0.489

High

521323

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.489

High

617503

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

1

High-throughput

0.489

High

640381

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.489

High

689819

CD27
CD27 antigen

1

2

High-throughput

0.489

High

835266

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

4

High-throughput

0.489

High

967300

TSN5
Tetraspanin-5

1

12

High-throughput

0.489

High

1053805

SARM1
NAD(+) hydrolase SARM1

1

3

High-throughput

0.489

High

1053810

STX12
Syntaxin-12

1

3

High-throughput

0.489

High

1053822

LPAR1
Lysophosphatidic acid receptor 1

1

13

High-throughput

0.489

High

1053834

TTYH3
Protein tweety homolog 3

1

2

High-throughput

0.489

High

1053838

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

3

High-throughput

0.489

High

1053841

LPAR2
Lysophosphatidic acid receptor 2

1

16

High-throughput

0.489

High

1053842

GPR35
G-protein coupled receptor 35

1

6

High-throughput

0.489

High

245921

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.470

High

720387

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

10

High-throughput

0.445

High

870226

S6A12
Sodium- and chloride-dependent betaine transporter

1

10

High-throughput

0.445

High

870354

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

10

High-throughput

0.445

High

1053803

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1053804

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.445

High

1053806

ZNT10
Calcium/manganese antiporter SLC30A10

1

6

High-throughput

0.445

High

1053815

S35F6
Solute carrier family 35 member F6

1

3

High-throughput

0.445

High

1053816

CTL3
Choline transporter-like protein 3

1

2

High-throughput

0.445

High

1053819

S35F5
Solute carrier family 35 member F5

1

3

High-throughput

0.445

High

1053820

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

1053832

S12A9
Solute carrier family 12 member 9

1

3

High-throughput

0.445

High

218092

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

588528

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695277

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

768018

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1053808

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1053824

TSN17
Tetraspanin-17

1

11

High-throughput

0.437

High

1053843

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

66384

T238L
Transmembrane protein 238-like

1

0

Small-scale

0.426

High

230955

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.426

High

1031778

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.426

High

1053795

S13A2
Solute carrier family 13 member 2

1

0

High-throughput

0.426

High

1053813

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.426

High

702763

5HT2C
5-hydroxytryptamine receptor 2C

1

5

High-throughput

0.407

High

704004

5HT1E
5-hydroxytryptamine receptor 1E

1

5

High-throughput

0.407

High

886047

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.407

High

1053802

S35F1
Solute carrier family 35 member F1

1

4

High-throughput

0.407

High

1053809

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

3

High-throughput

0.407

High

1053812

S22A9
Organic anion transporter 7

1

3

High-throughput

0.407

High

1053829

S1PR3
Sphingosine 1-phosphate receptor 3

1

13

High-throughput

0.407

High

1053811

RELL1
RELT-like protein 1

2

0

High-throughput

0.328

High

123373

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.279

Low

223619

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

223723

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.279

Low

251079

B4GT3
Beta-1,4-galactosyltransferase 3

1

0

High-throughput

0.279

Low

333572

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.279

Low

1053830

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.279

Low

1053835

COA1
Cytochrome c oxidase assembly factor 1 homolog

1

0

High-throughput

0.279

Low

1053839

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

1053844

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1053847

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.279

Low

1053850

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.279

Low

612998

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

773730

ACTN2
Alpha-actinin-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025