Protein: EXOS2
Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)

Gene: EXOS2, EXOSC2
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q13868

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1118344

EXOS3
Exosome complex component RRP40

11

5

Small-scale

0.977

High

1118340

EXOS4
Exosome complex component RRP41

10

20

Small-scale

0.976

High

1118279

EXOS7
Exosome complex component RRP42

9

20

Small-scale

0.973

High

1054460

EXOS9
Exosome complex component RRP45

7

20

Small-scale

0.956

High

1118321

MPH6
M-phase phosphoprotein 6

7

2

Small-scale

0.954

High

1118314

EXOS8
Exosome complex component RRP43

6

20

Small-scale

0.945

High

1118359

EXOS1
Exosome complex component CSL4

6

3

Small-scale

0.943

High

1118343

EXOS5
Exosome complex component RRP46

5

20

Small-scale

0.922

High

1118285

EXOS6
Exosome complex component MTR3

4

20

Small-scale

0.892

High

838716

MTREX
Exosome RNA helicase MTR4

3

6

Small-scale

0.839

High

1118313

FUBP2
Far upstream element-binding protein 2

3

0

Small-scale

0.784

High

1032159

EXOSX
Exosome complex component 10

6

5

Small-scale

0.727

High

1118307

DI3L1
DIS3-like exonuclease 1

5

5

Small-scale

0.722

High

1118362

RBM7
RNA-binding protein 7

3

1

High-throughput

0.667

High

1118273

C1D
Nuclear nucleic acid-binding protein C1D

3

0

Small-scale

0.634

High

1118358

RRP44
Exosome complex exonuclease RRP44

2

5

Small-scale

0.628

High

1118328

COMD4
COMM domain-containing protein 4

3

0

High-throughput

0.622

High

315575

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.618

High

854847

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.618

High

223022

PRC1
Protein regulator of cytokinesis 1

2

0

High-throughput

0.585

High

620357

NUCL
Nucleolin

2

0

High-throughput

0.585

High

1118288

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

0

High-throughput

0.585

High

1118312

RENT1
Regulator of nonsense transcripts 1

2

0

Small-scale

0.585

High

1118327

AICDA
Single-stranded DNA cytosine deaminase

2

0

Small-scale

0.585

High

1118360

HBS1L
HBS1-like protein

2

0

High-throughput

0.585

High

998300

H31
Histone H3.1

2

1

High-throughput

0.584

High

396077

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1118345

ANLN
Anillin

2

0

High-throughput

0.559

High

188488

NVL
Nuclear valosin-containing protein-like

1

2

High-throughput

0.536

High

231701

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.536

High

244692

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.536

High

655190

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.536

High

833105

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

859273

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

875656

PRC2A
Protein PRRC2A

1

2

High-throughput

0.536

High

992739

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1118281

WDR43
WD repeat-containing protein 43

1

4

High-throughput

0.536

High

1118283

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1118300

WDR75
WD repeat-containing protein 75

1

5

High-throughput

0.536

High

1118301

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.536

High

1118305

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

5

High-throughput

0.536

High

1118309

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1118331

SLK
STE20-like serine/threonine-protein kinase

1

2

High-throughput

0.536

High

1118356

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1118357

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

116288

H3BNT4
M-phase phosphoprotein 6

1

2

High-throughput

0.514

High

225583

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

0

High-throughput

0.513

High

287694

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

447002

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

548995

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.513

High

884084

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

889565

CLK2
Dual specificity protein kinase CLK2

1

0

High-throughput

0.513

High

908396

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

943646

SIK1
Serine/threonine-protein kinase SIK1

1

0

High-throughput

0.513

High

969850

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1050988

FAK1
Focal adhesion kinase 1

1

0

High-throughput

0.513

High

1104306

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.513

High

1118282

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.513

High

1118294

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1118295

NT5D3
5'-nucleotidase domain-containing protein 3

1

0

High-throughput

0.513

High

1118297

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1118308

PHF10
PHD finger protein 10

1

0

High-throughput

0.513

High

1118316

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1118351

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.513

High

1118354

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

951667

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1118332

PININ
Pinin

1

0

High-throughput

0.493

High

302516

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.486

High

1118336

ZN408
Zinc finger protein 408

1

0

High-throughput

0.486

High

157349

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

182291

WDR46
WD repeat-containing protein 46

1

5

High-throughput

0.479

High

252061

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

259926

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

472726

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

507949

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

979630

H4
Histone H4

1

1

High-throughput

0.479

High

1016841

H33
Histone H3.3

1

1

High-throughput

0.479

High

1118277

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1118280

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1118284

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1118287

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1118289

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

1118290

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1118292

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.479

High

1118296

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1118303

PTGR2
Prostaglandin reductase 2

1

1

High-throughput

0.479

High

1118304

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

1118311

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1118326

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

1118339

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1118347

DCA13
DDB1- and CUL4-associated factor 13

1

5

Small-scale

0.479

High

1118349

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

1118353

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

1118355

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.479

High

170130

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

317569

SLIT2
Slit homolog 2 protein

1

0

High-throughput

0.458

High

319750

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345789

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

371983

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

766536

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

881769

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.458

High

904694

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

914944

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.458

High

937745

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

1059226

TISB
mRNA decay activator protein ZFP36L1

1

0

Small-scale

0.458

High

1092120

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1118274

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

1118276

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1118291

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1118293

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1118298

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

Small-scale

0.458

High

1118302

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.458

High

1118306

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1118310

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1118315

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1118318

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1118319

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.458

High

1118320

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1118322

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1118323

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1118324

MET22
Methyltransferase-like protein 22

1

0

High-throughput

0.458

High

1118325

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1118330

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1118333

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1118335

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1118338

RENT2
Regulator of nonsense transcripts 2

1

0

Small-scale

0.458

High

1118341

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1118342

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1118348

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1118350

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1118361

TRI17
E3 ubiquitin-protein ligase TRIM17

1

0

Small-scale

0.458

High

3013

A0A0G2JJL1
WD repeat domain 46

1

6

High-throughput

0.445

High

96008

E7EWD6
ASXL transcriptional regulator 2

1

3

High-throughput

0.445

High

327999

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

1118334

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.445

High

429860

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1118337

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

108072

G3V3Y1
15-oxoprostaglandin 13-reductase

1

1

High-throughput

0.407

High

503701

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

0

High-throughput

0.316

High

66886

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

907903

PLXA3
Plexin-A3

1

0

High-throughput

0.279

Low

1118275

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1118299

GLT13
Polypeptide N-acetylgalactosaminyltransferase 13

1

0

High-throughput

0.251

Low

1118317

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.251

Low

1118346

SIA7A
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

1

0

High-throughput

0.251

Low

908606

LUM
Lumican

1

0

High-throughput

0.249

Low

1118278

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.249

Low

1118352

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1118286

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1118329

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025