Protein: EXOS3
Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)

Gene: EXOS3, EXOSC3
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9NQT5

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1447228

EXOS5
Exosome complex component RRP46

11

13

Small-scale

0.979

High

1446191

EXOS4
Exosome complex component RRP41

10

12

Small-scale

0.978

High

1118344

EXOS2
Exosome complex component RRP4

11

5

Small-scale

0.977

High

1447263

EXOS1
Exosome complex component CSL4

9

8

Small-scale

0.973

High

1032254

EXOSX
Exosome complex component 10

8

2

Small-scale

0.968

High

1384034

EXOS8
Exosome complex component RRP43

7

12

Small-scale

0.967

High

1054515

EXOS9
Exosome complex component RRP45

6

13

Small-scale

0.953

High

1137675

EXOS7
Exosome complex component RRP42

6

12

Small-scale

0.949

High

1209124

EXOS6
Exosome complex component MTR3

6

14

Small-scale

0.949

High

1405169

MPH6
M-phase phosphoprotein 6

9

0

Small-scale

0.922

High

838795

MTREX
Exosome RNA helicase MTR4

4

4

High-throughput

0.903

High

1353561

DI3L1
DIS3-like exonuclease 1

8

4

Small-scale

0.754

High

1447252

EXOS3
Exosome complex component RRP40

2

0

Small-scale

0.699

High

1447264

HBS1L
HBS1-like protein

5

0

Small-scale

0.689

High

1447265

RBM7
RNA-binding protein 7

5

0

High-throughput

0.688

High

1240267

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

0

High-throughput

0.670

High

1447262

RRP44
Exosome complex exonuclease RRP44

3

4

Small-scale

0.657

High

839925

AF9
Protein AF-9

3

0

High-throughput

0.638

High

1119080

C1D
Nuclear nucleic acid-binding protein C1D

3

0

High-throughput

0.638

High

1447266

CERT
Ceramide transfer protein

3

0

High-throughput

0.638

High

316048

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.618

High

1428548

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.618

High

1369398

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.613

High

1379858

TSR2
Pre-rRNA-processing protein TSR2 homolog

2

0

High-throughput

0.580

High

373234

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

397013

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1102376

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.547

High

1292415

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

Small-scale

0.537

High

833202

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

992979

RACK1
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.536

High

1141421

WDR43
WD repeat-containing protein 43

1

5

High-throughput

0.536

High

1151206

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1309715

WDR75
WD repeat-containing protein 75

1

5

High-throughput

0.536

High

1429081

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.536

High

1447261

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1447267

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.536

High

252172

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.513

High

447482

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

567492

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

908462

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

914969

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.513

High

922513

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

1251449

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.513

High

1447257

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1447258

TSKS
Testis-specific serine kinase substrate

1

0

High-throughput

0.513

High

1447260

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

1403204

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.486

High

423257

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

589781

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

1161692

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1368638

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1380184

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1386591

OPTN
Optineurin

1

1

High-throughput

0.479

High

1447254

DCA13
DDB1- and CUL4-associated factor 13

1

3

Small-scale

0.479

High

129461

MEN1
Menin

1

0

High-throughput

0.458

High

132320

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

157892

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

294377

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

320075

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

346376

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

363901

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

696595

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769264

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

897987

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

913812

ZN131
Zinc finger protein 131

1

0

High-throughput

0.458

High

937930

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

971138

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

980388

H4
Histone H4

1

0

High-throughput

0.458

High

981120

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1100421

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1138667

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1140912

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1155804

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1211673

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

High-throughput

0.458

High

1220829

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1275698

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

Small-scale

0.458

High

1290751

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1329892

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1352772

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1364610

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1393726

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1433976

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1447253

ANLN
Anillin

1

0

High-throughput

0.458

High

1447255

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1447256

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1447259

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

430399

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

952354

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

1130471

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1437342

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

608358

EGLN
Endoglin

1

0

High-throughput

0.279

Low

716742

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.251

Low

1126184

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1208115

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

0

High-throughput

0.249

Low

1392586

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025