Protein: MPH6
M-phase phosphoprotein 6

Gene: MPH6, MPHOSPH6
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q99547

Gene Ontology (top 5):
GO:0000178 - exosome (RNase complex)
GO:0000460 - maturation of 5.8S rRNA
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1118321

EXOS2
Exosome complex component RRP4

7

2

Small-scale

0.954

High

1405169

EXOS3
Exosome complex component RRP40

9

0

Small-scale

0.922

High

1405167

EXOS4
Exosome complex component RRP41

6

7

Small-scale

0.729

High

1137660

EXOS7
Exosome complex component RRP42

5

7

Small-scale

0.716

High

1384008

EXOS8
Exosome complex component RRP43

5

7

Small-scale

0.716

High

1405178

EXOS1
Exosome complex component CSL4

5

4

Small-scale

0.716

High

1405168

EXOS5
Exosome complex component RRP46

5

8

Small-scale

0.714

High

1032225

EXOSX
Exosome complex component 10

7

0

Small-scale

0.711

High

1054500

EXOS9
Exosome complex component RRP45

4

7

Small-scale

0.689

High

1119074

C1D
Nuclear nucleic acid-binding protein C1D

4

0

Small-scale

0.661

High

1209112

EXOS6
Exosome complex component MTR3

3

9

Small-scale

0.660

High

838775

MTREX
Exosome RNA helicase MTR4

4

0

Small-scale

0.658

High

244762

ZC3H1
Zinc finger C3H1 domain-containing protein

3

1

High-throughput

0.650

High

1353557

DI3L1
DIS3-like exonuclease 1

3

1

High-throughput

0.650

High

1085697

TBL3
Transducin beta-like protein 3

2

1

High-throughput

0.601

High

1405176

WDR3
WD repeat-containing protein 3

2

3

High-throughput

0.601

High

1240254

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

0

High-throughput

0.585

High

1405181

RBM7
RNA-binding protein 7

2

0

High-throughput

0.585

High

1325595

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

0

High-throughput

0.576

High

1336621

PAPD5
Terminal nucleotidyltransferase 4B

2

0

High-throughput

0.576

High

832107

IF2G
Eukaryotic translation initiation factor 2 subunit 3

2

0

High-throughput

0.559

High

914963

THOP1
Thimet oligopeptidase

2

0

High-throughput

0.551

High

248059

NUPR1
Nuclear protein 1

2

0

Small-scale

0.551

High

396781

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

415811

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

907328

APLP1
Amyloid beta precursor like protein 1

1

2

High-throughput

0.541

High

1141409

WDR43
WD repeat-containing protein 43

1

3

High-throughput

0.536

High

1144728

PWP2
Periodic tryptophan protein 2 homolog

1

2

High-throughput

0.536

High

1309704

WDR75
WD repeat-containing protein 75

1

2

High-throughput

0.536

High

1341131

WDR36
WD repeat-containing protein 36

1

2

High-throughput

0.536

High

1352442

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

2

High-throughput

0.536

High

1381577

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.536

High

1405163

ZN106
Zinc finger protein 106

1

1

High-throughput

0.536

High

1405177

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.536

High

414475

P53
Cellular tumor antigen p53

1

0

High-throughput

0.518

High

1047855

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.518

High

1105164

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1209155

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

1405173

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.518

High

422961

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

188522

NVL
Nuclear valosin-containing protein-like

1

0

High-throughput

0.513

High

1400241

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.513

High

1405165

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

1405182

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.513

High

384526

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.501

High

473006

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

1405039

SORT
Sortilin

1

1

High-throughput

0.479

High

1212442

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

129358

MEN1
Menin

1

0

High-throughput

0.458

High

157767

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

252146

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

284215

SRS10
Serine/arginine-rich splicing factor 10

1

0

Small-scale

0.458

High

315923

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

320000

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

386140

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

406547

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

937867

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

981039

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

988643

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

1017151

H33
Histone H3.3

1

0

High-throughput

0.458

High

1251416

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

1290670

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1352706

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1393623

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1405174

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1405180

HBS1L
HBS1-like protein

1

0

High-throughput

0.458

High

295228

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.438

High

337385

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.438

High

391422

FRIL
Ferritin light chain

1

0

High-throughput

0.438

High

896868

DYN2
Dynamin-2

1

0

High-throughput

0.438

High

903464

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

0

High-throughput

0.438

High

954241

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.438

High

1217183

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

1324914

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.438

High

1405171

AATF
Protein AATF

1

0

High-throughput

0.438

High

1405179

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.438

High

1405183

SNX9
Sorting nexin-9

1

0

High-throughput

0.438

High

360212

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.426

High

405533

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.426

High

599520

FAAA
Fumarylacetoacetase

1

0

High-throughput

0.426

High

892499

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.426

High

1405162

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

High-throughput

0.426

High

1405164

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.426

High

1405170

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.426

High

1405175

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.426

High

248414

GDF9
Growth/differentiation factor 9

1

0

High-throughput

0.282

High

1405172

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

1405166

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.238

Low

1397958

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025