Protein: EXOS6
Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) (hMtr3) (p11)

Gene: EXOS6, EXOSC6
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q5RKV6

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1137624

EXOS7
Exosome complex component RRP42

7

18

Small-scale

0.961

High

1209124

EXOS3
Exosome complex component RRP40

6

14

Small-scale

0.949

High

1209134

EXOS1
Exosome complex component CSL4

6

20

Small-scale

0.948

High

1209122

EXOS4
Exosome complex component RRP41

4

19

Small-scale

0.909

High

1118285

EXOS2
Exosome complex component RRP4

4

20

Small-scale

0.892

High

1209123

EXOS5
Exosome complex component RRP46

3

19

High-throughput

0.871

High

1209102

DI3L1
DIS3-like exonuclease 1

3

20

Small-scale

0.861

High

1209107

EXOS8
Exosome complex component RRP43

3

19

Small-scale

0.828

High

1054468

EXOS9
Exosome complex component RRP45

2

17

High-throughput

0.789

High

1032178

EXOSX
Exosome complex component 10

4

13

Small-scale

0.674

High

1209112

MPH6
M-phase phosphoprotein 6

3

9

Small-scale

0.660

High

1161483

IF16
Gamma-interferon-inducible protein 16

3

7

High-throughput

0.656

High

1119057

C1D
Nuclear nucleic acid-binding protein C1D

2

5

High-throughput

0.628

High

1209089

EXOS6
Exosome complex component MTR3

1

19

High-throughput

0.621

High

1209136

RBM7
RNA-binding protein 7

2

11

High-throughput

0.611

High

1209135

HBS1L
HBS1-like protein

2

6

Small-scale

0.595

High

838733

MTREX
Exosome RNA helicase MTR4

2

20

High-throughput

0.586

High

272244

OBSL1
Obscurin-like protein 1

2

4

High-throughput

0.584

High

830876

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

1209125

ANLN
Anillin

2

4

High-throughput

0.584

High

1209096

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

2

0

High-throughput

0.547

High

361275

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

563879

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

833123

MNDA
Myeloid cell nuclear differentiation antigen

1

7

High-throughput

0.536

High

1113305

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1209103

PHF10
PHD finger protein 10

1

7

High-throughput

0.536

High

1209117

AICDA
Single-stranded DNA cytosine deaminase

1

7

Small-scale

0.536

High

908409

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

608286

EGLN
Endoglin

1

1

High-throughput

0.489

High

178027

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

11

High-throughput

0.481

High

335689

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

1

High-throughput

0.481

High

344547

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

12

High-throughput

0.481

High

543579

ERR1
Steroid hormone receptor ERR1

1

13

High-throughput

0.481

High

688258

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.481

High

882708

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.481

High

1016469

SRSF3
Serine/arginine-rich splicing factor 3

1

2

High-throughput

0.481

High

1058060

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.481

High

1102844

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

10

High-throughput

0.481

High

1209098

DCP1B
mRNA-decapping enzyme 1B

1

1

High-throughput

0.481

High

1209099

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.481

High

1209116

RM04
Large ribosomal subunit protein uL4m

1

1

High-throughput

0.481

High

1209121

RENT2
Regulator of nonsense transcripts 2

1

2

High-throughput

0.481

High

1209131

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

13

High-throughput

0.481

High

123396

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

129157

MEN1
Menin

1

5

High-throughput

0.479

High

132092

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

170181

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

194226

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

252074

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

5

High-throughput

0.479

High

315670

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

335140

ARI2
E3 ubiquitin-protein ligase ARIH2

1

4

High-throughput

0.479

High

345915

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

372231

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

472798

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

11

High-throughput

0.479

High

832734

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.479

High

872406

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

897301

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

914948

THOP1
Thimet oligopeptidase

1

5

High-throughput

0.479

High

937777

FOXA1
Hepatocyte nuclear factor 3-alpha

1

3

High-throughput

0.479

High

970624

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

979786

H4
Histone H4

1

1

High-throughput

0.479

High

980828

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

1016919

H33
Histone H3.3

1

2

High-throughput

0.479

High

1092147

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

1106940

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1138292

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1155442

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

1194137

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1209091

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

5

High-throughput

0.479

High

1209092

GGYF2
GRB10-interacting GYF protein 2

1

6

High-throughput

0.479

High

1209094

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1209095

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.479

High

1209100

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.479

High

1209101

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1209104

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1209105

KAT6A
Histone acetyltransferase KAT6A

1

7

High-throughput

0.479

High

1209106

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

1209109

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

1209111

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

1209113

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1209114

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

1209115

CP250
Centrosome-associated protein CEP250

1

2

High-throughput

0.479

High

1209128

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

6

High-throughput

0.479

High

1209129

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1209133

FZR1
Fizzy-related protein homolog

1

14

High-throughput

0.479

High

72418

MI4GD
MIF4G domain-containing protein

1

0

High-throughput

0.460

High

228275

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.460

High

633706

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.460

High

1209097

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.460

High

1209118

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.460

High

1209126

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.460

High

1209127

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.460

High

1209137

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.460

High

257469

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

675048

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

791441

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

1209090

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1209108

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

430010

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

529933

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1111036

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

1209120

LN28A
Protein lin-28 homolog A

1

6

High-throughput

0.445

High

1209110

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.439

High

1209093

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1209119

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1209130

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

1209132

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

62538

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

1034468

TAGL
Transgelin

1

2

High-throughput

0.407

High

1130624

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.251

Low

635267

EFNA1
Ephrin-A1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025