Protein: TDG
G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG)

Gene: TDG
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q13569

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0003684 - damaged DNA binding
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

991319

SUMO1
Small ubiquitin-related modifier 1

7

2

Small-scale

0.967

High

964265

SUMO2
Small ubiquitin-related modifier 2

3

2

Small-scale

0.854

High

1110906

CBP
CREB-binding protein

6

1

Small-scale

0.735

High

939186

SUMO3
Small ubiquitin-related modifier 3

1

2

Small-scale

0.680

High

993555

UBC9
SUMO-conjugating enzyme UBC9

3

1

Small-scale

0.655

High

186750

P73
Tumor protein p73

2

2

Small-scale

0.633

High

413786

P53
Cellular tumor antigen p53

2

2

Small-scale

0.633

High

1110897

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.614

High

520576

RARA
Retinoic acid receptor alpha

2

3

Small-scale

0.595

High

1110910

P63
Tumor protein 63

1

2

Small-scale

0.573

High

371964

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.571

High

396059

ESR1
Estrogen receptor

1

5

Small-scale

0.561

High

1110912

DNM3B
DNA

1

1

Small-scale

0.561

High

827772

STAT3
Signal transducer and activator of transcription 3

2

0

High-throughput

0.551

High

855615

CRK
Adapter molecule crk

2

0

High-throughput

0.551

High

551030

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

714096

PML
Protein PML

1

0

Small-scale

0.537

High

1110908

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

1110911

DTL
Denticleless protein homolog

1

0

Small-scale

0.537

High

1110909

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.536

High

665257

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

Small-scale

0.515

High

1032809

XPC
DNA repair protein complementing XP-C cells

1

0

Small-scale

0.504

High

404039

GCR
Glucocorticoid receptor

1

6

Small-scale

0.501

High

442935

PRGR
Progesterone receptor

1

5

Small-scale

0.501

High

520022

ANDR
Androgen receptor

1

5

Small-scale

0.501

High

533276

THA
Thyroid hormone receptor alpha

1

3

Small-scale

0.501

High

543502

VDR
Vitamin D3 receptor

1

4

Small-scale

0.501

High

625810

RXRA
Retinoic acid receptor RXR-alpha

1

2

Small-scale

0.501

High

1067291

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.501

High

1110899

NCOA1
Nuclear receptor coactivator 1

1

0

Small-scale

0.493

High

245931

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

301417

WFS1
Wolframin

1

0

High-throughput

0.493

High

415547

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

451151

NFL
Neurofilament light polypeptide

1

0

High-throughput

0.493

High

705329

GRN
Progranulin

1

0

High-throughput

0.493

High

791368

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

954465

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

1110907

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1110913

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

555479

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

1106524

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.486

High

1110901

SETX
Probable helicase senataxin

1

0

Small-scale

0.486

High

603648

JUNB
Transcription factor JunB

1

1

High-throughput

0.481

High

253202

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.480

High

261721

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.480

High

1110900

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

1

High-throughput

0.479

High

1110914

DNM3A
DNA

1

1

Small-scale

0.479

High

332757

EPM2A
Laforin

1

0

Small-scale

0.460

High

633375

MX1
Interferon-induced GTP-binding protein Mx1

1

0

Small-scale

0.460

High

1055907

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.460

High

1104569

IKZF1
DNA-binding protein Ikaros

1

0

High-throughput

0.460

High

1110903

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.460

High

1110904

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.460

High

176062

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.458

High

187513

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

587076

ITF2
Transcription factor 4

1

0

Small-scale

0.458

High

617696

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

919943

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

931658

RD23B
UV excision repair protein RAD23 homolog B

1

0

Small-scale

0.458

High

1004535

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.458

High

1110902

ASTRC
Protein Aster-C

1

0

High-throughput

0.458

High

1110898

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.438

High

1110905

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

47328

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

389823

TTHY
Transthyretin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025