Protein: MGMT
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)

Gene: MGMT
Organism: Homo sapiens
Interactions: 86
UniProt ID: P16455

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596843

KPCA
Protein kinase C alpha type

2

1

Small-scale

0.602

High

550825

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.598

High

596852

CDK2
Cyclin-dependent kinase 2

2

1

Small-scale

0.584

High

395438

ESR1
Estrogen receptor

1

1

Small-scale

0.573

High

596857

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

Small-scale

0.559

High

596863

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.515

High

596844

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.501

High

596847

CSK22
Casein kinase II subunit alpha'

1

3

Small-scale

0.501

High

596871

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

240674

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

302106

CDKL5
Cyclin-dependent kinase-like 5

1

2

Small-scale

0.479

High

402839

ANXA1
Annexin A1

1

1

Small-scale

0.479

High

443159

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.479

High

456595

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

461116

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.479

High

462234

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

Small-scale

0.479

High

468036

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.479

High

551945

ADT1
ADP/ATP translocase 1

1

1

Small-scale

0.479

High

552116

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.479

High

596846

NUCL
Nucleolin

1

1

Small-scale

0.479

High

596849

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

Small-scale

0.479

High

596853

MCM3
DNA replication licensing factor MCM3

1

1

Small-scale

0.479

High

596861

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.479

High

596864

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

596869

EF1A1
Elongation factor 1-alpha 1

1

1

Small-scale

0.479

High

596873

H33
Histone H3.3

1

2

High-throughput

0.479

High

596877

EP300
Histone acetyltransferase p300

1

1

Small-scale

0.479

High

596882

CDK10
Cyclin-dependent kinase 10

1

2

Small-scale

0.479

High

596883

H31T
Histone H3.1t

1

2

Small-scale

0.479

High

596885

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

596886

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

596888

TBA1C
Tubulin alpha-1C chain

1

1

Small-scale

0.479

High

596891

DDX24
ATP-dependent RNA helicase DDX24

1

1

Small-scale

0.479

High

596893

PABP3
Polyadenylate-binding protein 3

1

1

Small-scale

0.479

High

596895

CDK12
Cyclin-dependent kinase 12

1

2

Small-scale

0.479

High

596890

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

128381

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

Small-scale

0.458

High

187456

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

187881

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

0

Small-scale

0.458

High

209197

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

0

Small-scale

0.458

High

302363

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

Small-scale

0.458

High

502224

H2A1
Histone H2A type 1

1

0

Small-scale

0.458

High

503542

H2BFM
Histone H2B type F-M

1

0

Small-scale

0.458

High

507069

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

541812

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

557836

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.458

High

572976

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

573746

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

596845

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

596848

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

596854

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.458

High

596855

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

0

Small-scale

0.458

High

596856

PHB1
Prohibitin 1

1

0

Small-scale

0.458

High

596858

MSH2
DNA mismatch repair protein Msh2

1

0

Small-scale

0.458

High

596862

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

596865

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

596866

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

596867

H4
Histone H4

1

0

Small-scale

0.458

High

596868

1433Z
14-3-3 protein zeta/delta

1

0

Small-scale

0.458

High

596870

TBB4B
Tubulin beta-4B chain

1

0

Small-scale

0.458

High

596872

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

596874

SET
Protein SET

1

0

Small-scale

0.458

High

596876

SSRP1
FACT complex subunit SSRP1

1

0

Small-scale

0.458

High

596878

MYO7A
Unconventional myosin-VIIa

1

0

Small-scale

0.458

High

596879

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.458

High

596880

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

596881

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

596887

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

596889

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

0

Small-scale

0.458

High

596896

DTL
Denticleless protein homolog

1

0

Small-scale

0.458

High

596897

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

596899

PSME2
Proteasome activator complex subunit 2

1

0

Small-scale

0.458

High

596851

KPCL
Protein kinase C eta type

1

1

Small-scale

0.437

High

596875

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

596884

FBX27
F-box only protein 27

1

1

Small-scale

0.437

High

596898

FBX2
F-box only protein 2

1

1

Small-scale

0.437

High

167475

WNT9B
Protein Wnt-9b

1

0

Small-scale

0.249

Low

322903

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

Small-scale

0.249

Low

428055

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.249

Low

474457

VIME
Vimentin

1

0

Small-scale

0.249

Low

596850

EF1B
Elongation factor 1-beta

1

0

Small-scale

0.249

Low

596859

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.249

Low

596860

TTPA
Alpha-tocopherol transfer protein

1

0

Small-scale

0.249

Low

596892

IL25
Interleukin-25

1

0

Small-scale

0.249

Low

596894

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

354526

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025